Results 41 to 50 of about 5,466 (169)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Exploring the advancements of Australian OPAT

Therapeutic Advances in Infectious Disease, 2023
Outpatient parenteral antimicrobial therapy (OPAT) in Australia has evolved from modest beginnings to a well-established health service with proven benefits in patient outcomes.
Tony Lai, Horst Thiele, Benjamin A. Rogers, Nadine Hillock, Suman Adhikari, Alexander McNamara, Matthew Rawlins   +6 more
doaj   +1 more source

Clinical benefit of faecal microbiota transplantation administered via a single retention enema as an adjunctive treatment in dogs with chronic enteropathy: a randomised controlled trial

Journal of Small Animal Practice, EarlyView.
Objectives To evaluate the clinical benefit of faecal microbiota transplantation administered via a single retention enema, as an adjunctive treatment in the management of dogs with chronic enteropathy. Materials and Methods Blinded, randomised controlled trial.
F. Allerton, M. J. Whittle, L. Durkin, C. Prior, M. Trehy, H. Swales, F. Duplan, S. Borgonovi, G. Pinchbeck, I. Gajanayake, M. Dunning, T. Sparks, P. Watson, G. C. A. Amos, K. McCallum, J. Bazelle, A. Kent   +16 more
wiley   +1 more source

Hospital at Home in 10 years—Here, borrow my binoculars

Journal of Internal Medicine, Volume 300, Issue 2, Page 153-163, August 2026.
Abstract Hospital in the Home (HAH) refers to the delivery of acute hospital care to patients at home, or in their usual place of care, including nursing homes. HAH is an acute hospital substitution service—it delivers medical, nursing and allied health staff, skills, interventions and treatments, technologies and supervision usually found in hospitals
Michael Montalto
wiley   +1 more source

Pediatric Outpatient Parenteral Antimicrobial Therapy: An Update

Advances in Pediatrics, 2010
M any terms have been used to describe the delivery of antimicrobials (antiviral, antifungal, or antibacterial agents) to patients in the outpatient setting through the parenteral (ie, intravenous, intramuscular, or subcutaneous) route, including outpatient intravenous antimicrobial therapy (OPIVAT), community-based parenteral anti-infective therapy ...
Pediatric Infectious Diseases and Immunology, University of Florida- Jacksonville West 8th Street, LRC-3, Pediatrics, L-13, Jacksonville, FL 32209, USA ( host institution ), Maraqa, Nizar F., Rathore, Mobeen H.   +2 more
openaire   +3 more sources

Tissue and Serum Concentrations of Time‐Dependent Antibiotics in Infected Diabetic Foot Ulcers by Bolus or Continuous Administration: The Randomised DFIATIM Trial

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 5, July 2026.
ABSTRACT Aims The clinical effectiveness of antibiotic (ATB) therapy in patients with infected diabetic foot ulcers (iDFUs) depends on achieving sufficient ATB concentrations in both serum and peripheral tissues. This study evaluated the availability and bactericidal activity of the time‐dependent ATBs—ceftazidime (CTZ) and amoxicillin/clavulanate (AMC)
Radka Jarošíková, Dominika Sojáková, Simona Antalová, Petr Tůma, Jan Polák, Michal Dubský, Andrea Němcová, Veronika Wosková, Pavol Beca, Istvan Modos, Jan Mareš, Jakub Mrázek, Chahrazed Mekadim, Markéta Skružná, Vladimíra Fejfarová   +14 more
wiley   +1 more source

Palliative outpatient parenteral antimicrobial therapy (OPAT): A single center experience and systematic scoping review

Clinical Infection in Practice, 2022
Traditionally, outpatient parenteral antimicrobial therapy (OPAT) is used to treat infections with predictable course and anticipated response to therapy. However, there has been little consideration of OPAT for palliation as opposed to cure.
Oyewole Chris Durojaiye, Ihsan Jibril, Evangelos I Kritsotakis   +2 more
doaj   +1 more source

Outpatient Parenteral Antimicrobial Therapy in Pediatric Medicaid Enrollees [PDF]

Journal of the Pediatric Infectious Diseases Society, 2016
Outpatient parenteral antimicrobial therapy (OPAT) is overused in cases where highly bioavailable oral alternatives would be equally effective. However, the scope of OPAT use for children nationwide is poorly understood. Our objective was to characterize OPAT use and clinical outcomes for a large population of pediatric Medicaid enrollees treated with ...
Jennifer L, Goldman, Troy, Richardson, Jason G, Newland, Brian, Lee, Jeffrey S, Gerber, Matt, Hall, Matthew, Kronman, Adam L, Hersh   +7 more
openaire   +2 more sources

Incidence, Mortality, and Determinants of Ventilator‐Associated Pneumonia Among Pediatric Patients at the National Referral Hospital, Bhutan: A Prospective Cohort Study

Health Science Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background Ventilator‐associated pneumonia (VAP) is a common healthcare‐associated infection in pediatric intensive care units (PICUs). In Bhutan, baseline data on VAP are limited. This study aimed to determine the incidence, mortality, and factors associated with VAP among mechanically ventilated pediatric patients at the Jigme Dorji ...
Tashi Tshering, Yeshey Dorjey, Kuenley Pedon, Mimi Lhamu Mynak   +3 more
wiley   +1 more source