Results 51 to 60 of about 239 (129)

Safety and Effectiveness of Outpatient Parenteral Antimicrobial Therapy (OPAT) in the Aged Population [PDF]

Open Forum Infectious Diseases, 2017
Abstract Background The aged population (≥75 years) have multiple comorbidities and are at increased risk of adverse events associated with intravenous antimicrobial therapy. Hospitalization (hosp) occurs frequently.
Van Anglen, Lucinda J, Mandel, Richard M, Nathan, Ramesh V, Krinsky, Andrew H, Luu, Quyen, Bacon, Alfred E, Baker, H Barry, Schroeder, Claudia P, Couch, Kimberly A   +8 more
openaire   +1 more source

A Review of β‐Lactamase Inhibitors in Clinical Use and Development: Mechanisms, Spectrum, and Therapeutic Applications

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
β‐Lactam antibiotics have long served as a cornerstone for treating bacterial infections. However, their widespread and often indiscriminate use has fueled the emergence of multidrug‐resistant Gram‐negative pathogens, primarily through the production and dissemination of β‐lactamase enzymes.
Mohammad Javad Roustaye Gourabi, Anita Nikoo, Bita Khanbabaei, Masoud Kargar, Amirhossein Fayyazi, Seyyed Mohammad Javad Mousavi, Amirhossein Aghdaee, Ali Hashemi, Javad Yasbolaghi Sharahi, Swaran J. S. Flora   +9 more
wiley   +1 more source

Evolving antimicrobial resistance in a patient receiving palliative OPAT for a vascular graft infection: A case report

Clinical Infection in Practice, 2019
Prosthetic vascular graft infection is devastating and frequently fatal. Cure requires removal of the graft and reperfusion by placement of a new graft. However, no evidence based guidelines exist for management where removal of the graft is not possible.
James W.D. Irvine, Ann L.N. Chapman, Carlos Varon Lopez, Kerry Reid, Michelle Spittal, Steven McCormick, Stephanie Dundas   +6 more
doaj   +1 more source

Abstract Supplement

Pulmonary Medicine, Volume 2026, Issue 1, 2026.
 
Marzia Folegani, Semonti Nandi
wiley   +1 more source

Successful Establishment of an Antimicrobial Stewardship Program (ASP) for Outpatient Parenteral Antimicrobial Therapy (OPAT) [PDF]

Open Forum Infectious Diseases, 2017
BACKGROUND: IDSA guidelines for implementing an ASP were published in 2016 with required standards by The Joint Commission for hospitals beginning January, 2017. To date, no guidelines have been established in the US for ASP specific to OPAT. Using current guidelines, along with those proposed for the UK, we developed an ASP program unique to OPAT ...
Nathan, Ramesh V, Adams, John S, Dretler, Robin H, Luu, Quyen, Metzger, Brian S, Schroeder, Claudia P, Couch, Kimberly, Van Anglen, Lucinda J   +7 more
openaire   +1 more source

Outpatient parenteral antimicrobial therapy in Germany: a prospective cohort study protocol

BMJ Open, 2022
Introduction Outpatient parenteral antimicrobial therapy (OPAT) means intravenous administration of antibiotics outside the hospital. The antibiotics are administered at the patient’s home.
Christina Samel, Holger Pfaff, Peter Ihle, Nadine Scholten, Martin Hellmich, Anna Hagemeier, Charlotte Leisse, Vanessa Brandes, Charlotte Oberröhrmann, Sophie Peter, Christoph H. Lindemann, Clara Lehmann   +11 more
doaj   +1 more source

Qualitative analysis of barriers and facilitators to healthcare engagement for people with injecting‐related invasive infections using a social ecological framework

Addiction, Volume 120, Issue 12, Page 2476-2488, December 2025.
Abstract Background and aims Injecting‐related bacterial infections are increasing in many countries. Systemic infections often require prolonged treatment. Evidence suggests that people who inject drugs who have invasive infections are less likely to complete antimicrobial treatment and have poorer outcomes than patients without a history of injecting
Lucy O. Attwood, Sophia E. Schroeder, Olga Vujovic, Andrew J. Stewardson, Joseph S. Doyle, Paul Dietze, Peter Higgs, Samantha Colledge‐Frisby   +7 more
wiley   +1 more source

Outpatient Parenteral Antimicrobial Therapy Practice in United Kingdom: A Single-center Experience

Oman Medical Journal, 2022
Objectives: This study sought to analyze the outpatient parenteral antimicrobial therapy (OPAT) services provided by a tertiary hospital, in terms of types and duration of antimicrobials administered, and assess whether these services were in line with ...
Damini Kesharwani, Anushruti Bista, Hardeep Singh, Ashwin Unnithan, Gautam Das, Sarah Bristoll, Nicki Lewis, Nadhim Alnoori   +7 more
doaj   +1 more source

Rezafungin Utilisation in Real Life—FungiScope Results From Europe and the United States

Mycoses, Volume 68, Issue 9, September 2025.
ABSTRACT Background Rezafungin, a novel echinocandin with once‐weekly intravenous dosing, offers potential advantages for outpatient parenteral antifungal therapy (OPAT) in invasive candidiasis (IC). While clinical trial data support its efficacy and safety, real‐world experience remains limited.
Ilana Reinhold, Giovanni Mori, Massimiliano Lanzafame, Alessandro Limongelli, Antonio Vena, Julia Götz, Stilla Bauernfeind, Frank Hanses, Lukas Tometten, Michael Mayer, Ansgar Rieke, Ana Soriano‐Martin, Maricela Valerio, Jose A. Vazquez, Patrick Yue, Laman Rahimli, Nijat Azimli, Ertan Sal, Jon Salmanton‐García, Natalia Vasenda, Rosanne Sprute, Jannik Stemler, Sebastian Wingen‐Heimann, Oliver A. Cornely, Danila Seidel   +24 more
wiley   +1 more source

A bundle of the top 10 OPAT publications in 2024

Antimicrobial Stewardship & Healthcare Epidemiology
Objective: Outpatient parenteral antimicrobial therapy (OPAT) is a mainstay of clinical infectious diseases practice, and OPAT-related publications continue to be prominent in journals.
Lindsey M. Childs-Kean, Sara F. Azimi, Alison M. Beieler, Laila Castellino, Sara C. Keller, Margaret Pertzborn, Alexandra Yamshchikov, Leah H. Yoke, Kathleen Young, Monica V. Mahoney   +9 more
doaj   +1 more source