Results 61 to 70 of about 229,438 (263)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Output Feedback-Based Neural Network Sliding Mode Control for Electro-Hydrostatic Systems with Unknown Uncertainties

Machines
This paper proposes an output feedback-based control for uncertain electro-hydrostatic systems (EHSs) to satisfy high output tracking precision under the influences of unknown mismatched and matched uncertainties and unstructured dynamical behavior.
Tri Dung Dang, Tri Cuong Do, Hoai Vu Anh Truong   +2 more
doaj   +1 more source

Output feedback disturbance rejection control for building structure systems subject seismic excitations

Measurement + Control, 2020
In this paper, the output feedback disturbance rejection control (OFDRC) problem is considered for buildings structures subject seismic excitations.
Qixun Lan, Xiaoguo Zhang, Yajie Li, Jingjing Mu, Weiping Zhu, Huafeng Xu   +5 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Output Feedback Adaptive Stabilization of Uncertain Nonholonomic Systems

Abstract and Applied Analysis, 2014
This paper investigates the problem of output feedback adaptive stabilization control design for a class of nonholonomic chained systems with uncertainties, involving virtual control coefficients, unknown nonlinear parameters, and unknown time delays ...
Yuanyuan Wu, Zicheng Wang, Yuqiang Wu, Qingbo Li   +3 more
doaj   +1 more source

Destabilization by output feedback

Differential and Integral Equations, 1992
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Hinrichsen, D., Pritchard, A. J.
openaire   +3 more sources

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Static Output Feedback Control Design for Descriptor Systems

Journal of Control Science and Engineering, 2010
The static output feedback (SOF) synthesis problem for descriptor systems is considered in this paper. LMI-based algorithms are proposed to find potentially structured SOF gains ensuring admissibility and even H∞ performance of the closed-loop system ...
Mohamed Yagoubi
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Finite-Time Prescribed Performance Neural Network Force Control of Electro-Hydraulic Proportional Load Simulator with Output Feedback

Actuators
This paper focus on the high accuracy force control of electro-hydraulic proportional load simulator (EHPLS). Firstly, to weaken the influence of the unknown dead zone of the proportional valve, a mathematic model with a smooth inverse dead zone was ...
Zhenle Dong, Chao Li, Pengxiang Zhang, Yilong Jia, Jianyong Yao, Long Liu   +5 more
doaj   +1 more source