Results 61 to 70 of about 1,055,207 (292)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Delayed Fuzzy Output Feedback H∞ Control for Offshore Structures
Journal of Marine Science and Engineering, 2020 Vibration damping of jacket platforms is among the significant issues in marine science and engineering, and the design of active vibration control schemes is very important to ensure the stability and safety of the jacket platforms against external ...
Hua-Nv Feng +3 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Compensation Observer-Based Adaptive Output Feedback Control for Multi-Agent Systems
Applied SciencesThis study presents a modified compensating observer control strategy for nonlinear multi-agent systems affected by unknown hysteresis signal loops.
Zhaoyuan Liu, Ye Liu
doaj +1 more source
Simultaneous Robust, Decoupled Output Feedback Control for Multivariate Industrial Systems
IEEE Access, 2018 This paper proposes a simultaneous robust decoupled output feedback control approach for multivariate industrial processes with parameter uncertainties.
Pengwei Li, Xu Yang, Yuri A. W. Shardt
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Dynamic Output Feedback Control of Cyber-Physical Systems Under DoS Attacks
IEEE Access, 2019 This paper focuses on dynamic output feedback control of Cyber-Physical Systems (CPS) under Denial-of-Service (DoS) attacks. Firstly, by analyzing the different effects of DoS attacks on the sensor-to-controller (S-C) channel and the controller-to ...
Zhiwen Wang +4 more
doaj +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source