Results 191 to 200 of about 122,669 (325)

Understanding of endo/lysosomal escape of nanomaterials in biomedical application

open access: yesSmart Molecules, EarlyView.
This review summarized mainstream mechanisms of endo/lysosomal escape and design strategies of endo/lysosomal escapable nanoparticles in view of surface charge, polarity & hydrophobicity, particle morphology, and lysosomal escape agents. The utilization of endo/lysosomal escapable nanoparticles for vaccine delivery and genetic engineering are ...
Xin Wang   +3 more
wiley   +1 more source

Cryomicroneedle Arrays for Biotherapeutics Delivery

open access: yesSmall Science, EarlyView.
CryoMNs for biotherapeutic delivery to treat various diseases. CryoMNs: cryomicroneedles. Biotherapy offers a promising approach for treating a variety of diseases. However, the lack of advanced delivery systems remains a significant barrier to improve the efficacy, safety, and cost‐effectiveness of biotherapeutics.
Chunli Yang   +9 more
wiley   +1 more source

Tailored Metal‐Organic Framework‐Based Enzyme Hybrids: Immobilization Strategies, Improved Performance, and Biological Applications

open access: yesSmall Science, EarlyView.
Metal‐organic frameworks (MOFs) offer versatile platforms for enzyme immobilization to overcome their inherent fragility. However, challenges such as restricted conformation and mass transfer limitations remain. Advances in precise MOF design can help overcome these obstacles, expanding their applicability across diverse fields, highlighting the ...
Xiang Xu   +4 more
wiley   +1 more source

Flexible and Reliable Parylene‐C Resistive Random Access Memory Array with Graphene Barrier for Neuromorphic Systems

open access: yesSmall Structures, EarlyView.
Resistive random‐access memory(RRAM) devices often suffer from Negative‐SET, which undermines their reliability. In this study, a graphene barrier is introduced to mitigate excessive conductive filament growth in flexible parylene‐C‐based RRAM arrays.
Seonjeong Lee   +5 more
wiley   +1 more source

Allergic Reactivity and Memory Occur Independently of Sequential Switching Through IgG1

open access: yesAllergy, EarlyView.
Sequential switching through IgG1 is not required to produce IgE with sufficient allergen‐binding affinity to cause anaphylaxis against food allergens. Sequential switching through IgG1 does not confer a competitive advantage to become an IgE‐expressing cell.
Joshua F. E. Koenig   +11 more
wiley   +1 more source

BLOC1S1 Control of Vacuolar Organelle Fidelity Modulates Murine TH2 Cell Immunity and Allergy Susceptibility

open access: yesAllergy, EarlyView.
Abbreviations: BLOC1S1, biogenesis of lysosome organelles complex 1 subunit 1; cGAS, cyclic GMP‐AMP synthase; GATA3, GATA binding protein 3; IgE, immunoglobulin E; IKK, inhibitor of nuclear factor kappa‐B kinase; IL, interleukin; mtDNA, mitochondrial DNA; NF‐κB, nuclear factor‐kappa B; OVA, ovalbumin; MC903, vitamin D3 analog; STING, stimulator of ...
Rahul Sharma   +8 more
wiley   +1 more source

Radiofrequency and microwave 3D bioprinting of emulsion gel for dysphagia diets. [PDF]

open access: yesSci Rep
Tsubaki S   +5 more
europepmc   +1 more source

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