Results 201 to 210 of about 47,234 (246)

Editorial: Genetics and epigenetics in ovarian aging. [PDF]

Front Endocrinol (Lausanne)
Reddi HV.
europepmc   +1 more source

Real‐world‐data for phenotypes and genotypes of rare monogenic genetic epilepsies and genes of uncertain significance for epilepsy

Epilepsia Open, EarlyView.
Abstract Objectives The objectives of this study were to develop a real‐world‐data (RWD) database for patients with epilepsy to provide further real‐world‐evidence (RWE) for monogenic genetic epilepsies; to assess the usefulness of a diagnostic algorithm in epilepsy; and to examine protein 3D structures using in silico tools to predict variant ...
Haley Morris, Elizabeth Mathew, Shalini Bahl, Marta Villa‐Lopez, Saadet Mercimek‐Andrews   +4 more
wiley   +1 more source

Sirtuins and their role in ovarian aging-related fibrosis predisposing to ovarian cancer. [PDF]

NPJ Aging
Grzeczka A, Skowronska A, Sepe S, Skowronski MT, Kordowitzki P.   +4 more
europepmc   +1 more source

Oxidative Stress and <i>SIRT1</i>-Nrf2 Anti-Ferroptotic Pathways in Granulosa Cells: A Molecular Key to Follicular Atresia and Ovarian Aging. [PDF]

Int J Mol Sci
Voros C, Chatzinikolaou F, Papadimas G, Polykalas S, Mavrogianni D, Koulakmanidis AM, Athanasiou D, Kanaka V, Bananis K, Athanasiou A, Athanasiou A, Papapanagiotou I, Tsimpoukelis C, Karpouzos A, Daskalaki MA, Kanakas N, Theodora M, Thomakos N, Antsaklis P, Loutradis D, Daskalakis G.   +20 more
europepmc   +1 more source

Interplay of Oxidative Stress, Autophagy, and Rubicon in Ovarian Follicle Dynamics: Orchestrating Ovarian Aging. [PDF]

Antioxidants (Basel)
Yamada K, Ito M, Nunomura H, Nishigori T, Furuta A, Yoshida M, Yamaki A, Shozu K, Yasuda I, Tsuda S, Shima T, Nakashima A.   +11 more
europepmc   +1 more source

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Hallmarks of ovarian aging

Trends in Endocrinology and Metabolism
Ovarian aging is considered to be the pacemaker of female aging, and is linked to various comorbidities such as osteoporosis, cardiovascular diseases, and cognitive decline. Many efforts have been made to determine the mechanisms underlying ovarian aging, but their potential to act as hallmarks to predict and intervene in this process currently remains
Chuqing Wu, Michael B Stout, Shixuan Wang   +2 more
exaly   +3 more sources

Primary Ovarian Insufficiency and Ovarian Aging

Obstetrics and Gynecology Clinics of North America, 2023
Primary ovarian insufficiency (POI) is a complex condition of aberrant ovarian aging. POI etiologies are varied, and most cases have no identifiable underlying cause. Caring for women with POI requires an approach that understands the importance of ovarian function in a variety of target organs and tissues.
openaire   +2 more sources

General ageing and ovarian ageing

Maturitas, 1998
The age related decrease in female fertility is associated with a decrease in follicle numbers and oocyte quality. Meiotic division errors, mitochondrial DNA mutations and ageing itself have been suggested to play a part in the age associated reduction in oocyte quality.
M, Dorland, R J, van Kooij, E R, te Velde   +2 more
openaire   +2 more sources

Early ovarian ageing

European Journal of Obstetrics & Gynecology and Reproductive Biology, 2004
Observations from reproductive biology, epidemiology, and clinical assisted reproduction support the hypothesis that the time interval between the onset of accelerated decline of the ovarian reserve and the menopause is more or less fixed. Thus, it is estimated that women who become menopausal by the age of 45 may have experienced an accelerated ...
D, Nikolaou, A, Templeton
openaire   +2 more sources

Ovarian failure and ageing

Clinics in Endocrinology and Metabolism, 1981
Summary It is difficult to separate the true symptoms of oestrogen deficiency from symptoms of ageing and the effects of social and domestic problems of the middle-aged woman, but a careful history eliciting vasomotor symptoms or atrophic vaginitis, or a recent onset of psychogenic symptoms, identifies the patient who might benefit from the only ...
J W, Studd, M H, Thom
openaire   +2 more sources