Patient level simulation and reinforcement learning to discover novel strategies for treating ovarian cancer [PDF]
arXiv, 2021 The prognosis for patients with epithelial ovarian cancer remains dismal despite improvements in survival for other cancers. Treatment involves multiple lines of chemotherapy and becomes increasingly heterogeneous after first-line therapy. Reinforcement learning with real-world outcomes data has the potential to identify novel treatment strategies to ...
arxiv
Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer.
New England Journal of Medicine, 2016 BACKGROUND Niraparib is an oral poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) 1/2 inhibitor that has shown clinical activity in patients with ovarian cancer.
M. Mirza +27 more
semanticscholar +1 more source
Germline and Somatic Tumor Testing in Epithelial Ovarian Cancer: ASCO Guideline.
Journal of Clinical Oncology, 2020 PURPOSE To provide recommendations on genetic and tumor testing for women diagnosed with epithelial ovarian cancer based on available evidence and expert consensus.
P. Konstantinopoulos +11 more
semanticscholar +1 more source
In Vitro Chemosensitivity Using the Histoculture Drug Response Assay in Human Epithelial Ovarian Cancer [PDF]
, 2012 The choice of chemotherapeutic drugs to treat patients with epithelial ovarian cancer has not depended on individual patient characteristics. We have investigated the correlation between in vitro chemosensitivity, as determined by the histoculture drug ...
Kim, Dae-Yeon +6 more
core +1 more source
Leveraging mid-infrared spectroscopic imaging and deep learning for tissue subtype classification in ovarian cancer [PDF]
, 2022 Mid-infrared spectroscopic imaging (MIRSI) is an emerging class of label-free techniques being leveraged for digital histopathology. Modern histopathologic identification of ovarian cancer involves tissue staining followed by morphological pattern recognition. This process is time-consuming, subjective, and requires extensive expertise.
arxiv +1 more source
Immunotherapy for Ovarian Cancer: Adjuvant, Combination, and Neoadjuvant
Frontiers in Immunology, 2020 Ovarian cancer is the most lethal gynecologic malignancy. Surgery and chemotherapy are the primary treatments for ovarian cancer; however, patients often succumb to recurrence with chemotherapeutic resistance within several years after the initial ...
Chang Yang +5 more
semanticscholar +1 more source
Medical treatment of early stage and rare histological variants of epithelial ovarian cancer [PDF]
, 2015 Epithelial ovarian cancer is often considered a single pathological entity, but increasing evidence suggests that it is rather a group of different neoplasms, each with unique pathological characteristics, molecular features, and clinical behaviours ...
Biglia, Nicoletta +6 more
core +3 more sources
LINE-1 ORF1p as a candidate biomarker in high grade serous ovarian carcinoma
Scientific Reports, 2023 Long interspersed element 1 (LINE-1) open reading frame 1 protein (ORF1p) expression is a common feature of many cancer types, including high-grade serous ovarian carcinoma (HGSOC).
Sho Sato +19 more
doaj +1 more source
Breast Cancer, 2020 Breast cancer is a common cancer affecting a large number of patients. Notably, 5–10% of all breast cancer patients are genetically predisposed to cancers.
Reiko Yoshida
semanticscholar +1 more source
The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line. [PDF]
, 2011 The voltage gated potassium (K+) channels Eag and HERG have been implicated in the pathogenesis of various cancers, through association with cell cycle changes and programmed cell death.
Anish Bali +6 more
core +5 more sources