Results 61 to 70 of about 5,108,464 (344)

Whole Tumor Antigen Vaccines: Where Are We?

Vaccines, 2015
With its vast amount of uncharacterized and characterized T cell epitopes available for activating CD4+ T helper and CD8+ cytotoxic lymphocytes simultaneously, whole tumor antigen represents an attractive alternative source of antigens as compared to ...
Cheryl Lai-Lai Chiang, George Coukos, Lana E. Kandalaft   +2 more
doaj   +1 more source

Exosomes promote pre-metastatic niche formation in ovarian cancer. [PDF]

, 2019
Ovarian cancer is one of the most common gynecological malignancies. Upon initial diagnosis, the majority of patients present with widespread metastatic growth within the peritoneal cavity. This metastatic growth occurs in stages, with the formation of a
Dean, Dylan C, Duan, Zhenfeng, Feng, Wenlong, Hornicek, Francis J, Shi, Huirong   +4 more
core   +2 more sources

Immunotherapy for Ovarian Cancer: Adjuvant, Combination, and Neoadjuvant

Frontiers in Immunology, 2020
Ovarian cancer is the most lethal gynecologic malignancy. Surgery and chemotherapy are the primary treatments for ovarian cancer; however, patients often succumb to recurrence with chemotherapeutic resistance within several years after the initial ...
Chang Yang, B. Xia, Zhaocong Zhang, Yong-Jian Zhang, G. Lou, Wei-Lin Jin   +5 more
semanticscholar   +1 more source

Multi-gene panel testing for hereditary cancer predisposition in unsolved high-risk breast and ovarian cancer patients. [PDF]

, 2017
PurposeMany women with an elevated risk of hereditary breast and ovarian cancer have previously tested negative for pathogenic mutations in BRCA1 and BRCA2. Among them, a subset has hereditary susceptibility to cancer and requires further testing.
Adams, Sophie B, Chan, Salina, Crawford, Beth, Gil, Elad, Leitner, Ofri, Ryan, Lauren, Sittler, Taylor, van 't Veer, Laura, van den Akker, Jeroen   +8 more
core   +1 more source

The Role of Tumor-Associated Macrophages in the Progression and Chemoresistance of Ovarian Cancer

Cells, 2020
Tumor-associated macrophages (TAMs) constitute the main population of immune cells present in the ovarian tumor microenvironment. These cells are characterized by high plasticity and can be easily polarized by colony-stimulating factor-1, which is ...
M. Nowak, M. Klink
semanticscholar   +1 more source

Control of triple-negative breast cancer using ex vivo self-enriched, costimulated NKG2D CAR T cells

Journal of Hematology & Oncology, 2018
Background Triple-negative breast cancer (TNBC) is an aggressive disease that currently lacks effective targeted therapy. NKG2D ligands (NKG2DLs) are expressed on various tumor types and immunosuppressive cells within tumor microenvironments, providing ...
Yali Han, Wei Xie, De-Gang Song, Daniel J. Powell   +3 more
doaj   +1 more source

LINE-1 ORF1p as a candidate biomarker in high grade serous ovarian carcinoma

Scientific Reports, 2023
Long interspersed element 1 (LINE-1) open reading frame 1 protein (ORF1p) expression is a common feature of many cancer types, including high-grade serous ovarian carcinoma (HGSOC).
Sho Sato, Michael Gillette, Pamela R. de Santiago, Eric Kuhn, Michael Burgess, Kristen Doucette, Yi Feng, Carlos Mendez-Dorantes, Paul J. Ippoliti, Sara Hobday, Marilyn A. Mitchell, Kai Doberstein, Stefan M. Gysler, Michelle S. Hirsch, Lauren Schwartz, Michael J. Birrer, Steven J. Skates, Kathleen H. Burns, Steven A. Carr, Ronny Drapkin   +19 more
doaj   +1 more source

Human epididymis protein 4 (HE4) in benign and malignant diseases [PDF]

, 2012
Background: Human epididymis protein 4 (HE4) is described as a useful new biomarker in ovarian cancer. As HE4 is neither tumor nor organ specific, we intensively investigated the occurrence of this protein in female and male patients with various benign ...
Anastasi, Anastasi, Andersen, Andersen, Bast, Bast, Drapkin, Drapkin, Duffy, Duffy, Escudero, Escudero, Galgano, Galgano, Heintz, Heintz, Hellstrom, Hellstrom, Hellstrom, Hellstrom, Holcomb, Holcomb, Huhtinen, Huhtinen, Jacob, Jacob, Jacobs, Jacobs, Kurman, Kurman, Liu, Liu, Montagnana, Montagnana, Moore, Moore, Nolen, Nolen, Tuxen, Tuxen   +39 more
core   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Quercetin and cancer: new insights into its therapeutic effects on ovarian cancer cells

Cell & Bioscience, 2020
Ovarian cancer is known as a serious malignancy that affects women’s reproductive tract and can considerably threat their health. A wide range of molecular mechanisms and genetic modifications have been involved in ovarian cancer pathogenesis making it ...
Asma Vafadar, Zahra Shabaninejad, A. Movahedpour, F. Fallahi, Mona Taghavipour, Y. Ghasemi, Maryam Akbari, Alimohammad Shafiee, Sarah Hajighadimi, Sanaz Moradizarmehri, E. Razi, A. Savardashtaki, H. Mirzaei   +12 more
semanticscholar   +1 more source