Nature Communications, 2019 OPCML is a tumour suppressor gene that is epigenetically silenced in ovarian cancer and is somatically mutated in various cancers. Here, the authors solve the X-ray crystal structure of OPCML and model clinically relevant mutations that could contribute ...
James R. Birtley +17 more
doaj +1 more source
Ovarian volume throughout life: a validated normative model [PDF]
, 2013 The measurement of ovarian volume has been shown to be a useful indirect indicator of the ovarian reserve in women of reproductive age, in the diagnosis and management of a number of disorders of puberty and adult reproductive function, and is under investigation as a screening tool for ovarian cancer.
arxiv +1 more source
Treating cisplatin-resistant cancer: a systematic analysis of oxaliplatin or paclitaxel salvage chemotherapy [PDF]
, 2009 Objective: To examine the pre-clinical and clinical evidence for the use of oxaliplatin or paclitaxel salvage chemotherapy in patients with cisplatin-resistant cancer.
B Stordal +7 more
core +2 more sources
Ovarian Cancer Prediction from Ovarian Cysts Based on TVUS Using Machine Learning Algorithms [PDF]
arXiv, 2021 Ovarian Cancer (OC) is type of female reproductive malignancy which can be found among young girls and mostly the women in their fertile or reproductive. There are few number of cysts are dangerous and may it cause cancer. So, it is very important to predict and it can be from different types of screening are used for this detection using Transvaginal ...
arxiv
Quercetin and cancer: new insights into its therapeutic effects on ovarian cancer cells
Cell & Bioscience, 2020 Ovarian cancer is known as a serious malignancy that affects women’s reproductive tract and can considerably threat their health. A wide range of molecular mechanisms and genetic modifications have been involved in ovarian cancer pathogenesis making it ...
Asma Vafadar +12 more
semanticscholar +1 more source
Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer [PDF]
, 2016 The small GTPase Rab25 has been functionally linked to tumour progression and aggressiveness in ovarian cancer and promotes invasion in three-dimensional environments.
Chalmers, Anthony J. +3 more
core +1 more source
Whole Tumor Antigen Vaccines: Where Are We?
Vaccines, 2015 With its vast amount of uncharacterized and characterized T cell epitopes available for activating CD4+ T helper and CD8+ cytotoxic lymphocytes simultaneously, whole tumor antigen represents an attractive alternative source of antigens as compared to ...
Cheryl Lai-Lai Chiang +2 more
doaj +1 more source
Early Detection of Ovarian Cancer by Wavelet Analysis of Protein Mass Spectra [PDF]
arXiv, 2022 Accurate and efficient detection of ovarian cancer at early stages is critical to ensure proper treatments for patients. Among the first-line modalities investigated in studies of early diagnosis are features distilled from protein mass spectra. This method, however, considers only a specific subset of spectral responses and ignores the interplay among
arxiv
MDR1 siRNA loaded hyaluronic acid-based CD44 targeted nanoparticle systems circumvent paclitaxel resistance in ovarian cancer. [PDF]
, 2015 Development of multidrug resistance (MDR) is an almost universal phenomenon in patients with ovarian cancer, and this severely limits the ultimate success of chemotherapy in the clinic.
Amiji, Mansoor M +6 more
core +1 more source
MET nucleotide variations and amplification in advanced ovarian cancer: characteristics and outcomes with c-Met inhibitors. [PDF]
, 2013 PurposeMET alterations including amplifications and nucleotide variations have been associated with resistance to therapy and aggressive clinical behavior.Experimental designThe medical records of patients presenting to the University of Texas MD ...
De Melo Galgiato, Debora +13 more
core +6 more sources