Results 61 to 70 of about 153,874 (301)

The PENDOR study: establishment of a panel of patient-derived tumor organoids from endometrial cancer to assess efficacy of PARP inhibitors

BMC Cancer
Background Combination of chemotherapy and immunotherapy is the current standard of care for advanced endometrial cancer. However, survival outcome remains poor, highlighting the urgent need for new treatments and reliable tools to identify patients who ...
Gwenn Le Gall, François Cherifi, Jordane Divoux, Romane Florent, François Christy, Alexandra Leconte, Chankannira San, Amélie Devillers, Guillaume Desmartin, Lucie Lecouflet, Bénédicte Clarisse, Samantha Ballesta, Lucie Thorel, Brice Dubois, Valentin Harter, Nathalie Rousseau, Léopold Gaichies, Sandrine Martin-Françoise, Jean-François Le Brun, Enora Dolivet, Roman Rouzier, Corinne Jeanne, Cécile Blanc-Fournier, Martin Figeac, Raphaël Leman, Laurent Castera, Laurent Poulain, Louis-Bastien Weiswald, Florence Joly   +28 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Ovarian cancer prevention and screening – where do we stand today?

Journal of Mind and Medical Sciences
Widely recognized as the most deathful gynecologic malignancy affecting women worldwide, ovarian cancer has reported a significant decline in terms of prevalence and incidence in the last decades.
Cristina Bucur, Irina Balescu, Sorin Petrea, Bogdan Gaspar, Lucian Pop, Valentin Varlas, Adrian Hasegan, Marilena Stoian, Gabriel Petre Gorecki, Nicolae Bacalbasa   +9 more
doaj   +1 more source

A population-based analysis of germline BRCA1 and BRCA2 testing among ovarian cancer patients in an era of histotype-specific approaches to ovarian cancer prevention

BMC Cancer, 2018
Background Identifying female carriers of BRCA1 and BRCA2 mutations is imperative for prevention of ovarian cancer and breast cancer. There are five major histologic subtypes of ovarian cancer and high grade serous cancer (the most common) is reported in
Gillian E. Hanley, Jessica N. McAlpine, Dianne Miller, David Huntsman, Kasmintan A. Schrader, C. Blake Gilks, Gillian Mitchell   +6 more
doaj   +1 more source

Prevalence and clinical implications of germline mutations among Jordanian patients with ovarian cancer. The Jordanian exploratory cancer genetics (Jo‐ECAG) ovarian study

Molecular Genetics & Genomic Medicine, 2023
Background Ovarian cancer is one of the most common gynecological malignancies. Due to the absence of effective screening methods, ovarian cancer is usually diagnosed at late stages. Patients with pathogenic and likely‐pathogenic germline variants (PGVs)
Hikmat Abdel‐Razeq, Khansa Al‐Azzam, Shatha Elemian, Hala Abu‐Fares, Areej Abu Sheikha, Hira Bani Hani, Rayan Bater, Baha’ Sharaf, Brandie Heald, Edward D. Esplin, Sarah M. Nielsen, Mais Alkyam, Lama Abujamous, Areej Al‐Attary   +13 more
doaj   +1 more source

Vaccines in Current Culture: The HPV Vaccine Controversy [PDF]

, 2020
The use of vaccinations has drastically decreased mortality and morbidity rates related to infectious disease and has become an intrinsic part of modern health care.
Johnston, Alyssa
core   +1 more source

Cancer as a chronic disease : a psychological perspective [PDF]

, 2018
Cancer is a disease that affects many people. Therefore, issue of proper psychological adaptation to the disease is of utmost importance and allows one to look for a better understanding in similar fields.
Paleczna, Monika
core   +3 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

10-Gingerol Inhibits Ovarian Cancer Cell Growth by Inducing G2 Arrest [PDF]

Advanced Pharmaceutical Bulletin, 2019
Purpose: Gingerol homologs found in the rhizomes of ginger plants have the potential to benefit human health, including the prevention and treatment of cancer. This study evaluated the effect of 10-gingerol on ovarian cancer cell (HEY, OVCAR3, and SKOV-3)
Andrea Rasmussen, Kaylee Murphy, David W. Hoskin   +2 more
doaj   +1 more source

Activation of AMP-activated protein kinase by metformin induces protein acetylation in prostate and ovarian cancer cells [PDF]

, 2016
AMP-activated protein kinase (AMPK) is an energy sensor and master regulator of metabolism. AMPK functions as a fuel gauge monitoring systemic and cellular energy status.
Galdieri, Luciano, Gatla, Himavanth, Vancura, Ales, Vancurova, Ivana   +3 more
core   +2 more sources