Results 61 to 70 of about 4,801,388 (251)

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Homologous recombination deficiency (HRD) tests for ovarian cancer: a multicenter French phase II study (HERO)

BMC Cancer
Background The identification of homologous recombination deficient (HRD) tumor is now a crucial step for the therapeutic management of ovarian cancer. The HRD tumors are both sensitive to olaparib maintenance treatment and to platinum-based chemotherapy.
Raphaël Leman, François Cherifi, Marianne Leheurteur, Pierrick Theret, Camille Pasquesoone, Mathilde Saint-Ghislain, Lucie Bresson, Christophe Denoyelle, Nicolas Vigneron, Laurent Poulain, Raphaël Delepee, Benoit Berby, Julie Dremaux, Aurélie Dumont, Cécile Blanc-Fournier, Corinne Jeanne, Mélanie Briand, Nathalie Rousseau, Louis-Ferdinand Pepin, Elodie Deruche, Fabienne Dumont, Alexandra Leconte, Justine Lequesne, Bénédicte Clarisse, Florence Joly, Laurent Castera, Roman Rouzier   +26 more
doaj   +1 more source

10-Gingerol Inhibits Ovarian Cancer Cell Growth by Inducing G2 Arrest [PDF]

Advanced Pharmaceutical Bulletin, 2019
Purpose: Gingerol homologs found in the rhizomes of ginger plants have the potential to benefit human health, including the prevention and treatment of cancer. This study evaluated the effect of 10-gingerol on ovarian cancer cell (HEY, OVCAR3, and SKOV-3)
Andrea Rasmussen, Kaylee Murphy, David W. Hoskin   +2 more
doaj   +1 more source

Ovarian cancer symptom awareness and anticipated delayed presentation in a population sample [PDF]

, 2014
Background While ovarian cancer is recognised as having identifiable early symptoms, understanding of the key determinants of symptom awareness and early presentation is limited.
White, Ceri, Alice E Simon, Brain, Kate E, Smits, Stephanie, Brain, Katherine, Hanson, Jane, Neal, RD, Grp, ICBPM2W, Lindsay J Forbes, Kate E Brain, Neal, Richard D., Robbe, IJ, Hanson, J, Robbe, Iain, Roberts, C, Smits, S M, Iain J Robbé, John Steward, Roberts, Chris, Brain, KE, Stephanie Smits, Forbes, Lindsay J., Jane Hanson, Forbes, LJ, Richard D Neal, Simon, Alice E, Ceri White, Chris Roberts, Robbé, Iain J., Steward, John, White, C, Simon, Alice E., Simon, AE, Forbes, Lindsay, Forbes, Lindsay J.L., Smits, S, Brain, Kate E., Steward, J, Neal, Richard   +38 more
core   +2 more sources

Population-based Genetic Testing for Precision Prevention [PDF]

, 2020
Global interest in genetic-testing for Cancer-Susceptibility-Genes (CSG) has surged with falling costs, increasing awareness and celebrity endorsement.
Manchanda, R, Evans, O
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Global, regional, and national burden of ovarian cancer due to high BMI, 1990–2021 and projections to 2050: a systematic analysis based on the global burden of disease 2021 study

Frontiers in Nutrition
Using GBD 2021 data, this study quantifies the disease burden of ovarian cancer attributable to high BMI—encompassing mortality and disability-adjusted life years (DALYs)—across 204 countries/regions globally between 1990 and 2021.
Shuiqing Xu, Xiaotong Fu, Ming Wang
doaj   +1 more source

BRIP1, RAD51C, and RAD51D mutations are associated with high susceptibility to ovarian cancer: mutation prevalence and precise risk estimates based on a pooled analysis of ~30,000 cases

Journal of Ovarian Research, 2020
Background It is estimated that more than 20% of ovarian cancer cases are associated with a genetic predisposition that is only partially explained by germline mutations in the BRCA1 and BRCA2 genes.
Malwina Suszynska, Magdalena Ratajska, Piotr Kozlowski   +2 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source