Results 1 to 10 of about 35,228 (288)

Biomimetic hydrogels with mesoscale collagen architecture for patient-derived tumor organoids culture [PDF]

Bioactive Materials
Patient-derived tumor organoids (PDTOs) shows great potential as a preclinical model. However, the current methods for establishing PDTOs primarily focus on modulating local properties, such as sub-micrometer topographies.
Jiaxin Wang, Zhilin Sui, Wei Huang, Zhentao Yu, Ling Guo   +4 more
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Patient-Derived Tumor Organoids: New Progress and Opportunities to Facilitate Precision Cancer Immunotherapy [PDF]

Frontiers in Oncology, 2022
Cancer immunotherapy has revolutionized the field of cancer treatment in recent years. However, not all patients receiving cancer immunotherapy exhibit durable responses, and reliable, high-throughput testing platforms are urgently needed to guide ...
Ji Wang, Chao Chen, Chao Chen, Chao Chen, Lu Wang, Mingjun Xie, Mingjun Xie, Xinyang Ge, Sufan Wu, Yong He, Yong He, Yong He, Yong He, Xiaozhou Mou, Chenyang Ye, Chenyang Ye, Chenyang Ye, Yi Sun   +17 more
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Chinese experts consensus on quality control standards for tumor organoids diagnosis and treatment platform (2022 version) [PDF]

Zhongguo aizheng zazhi, 2022
Recently, advances in organoid technology have opened new avenues for the development of novel models of human cancer. Patient-derived tumor organoids retain phenotypes such as histopathological, genetic and molecular features of the original tumor.
The Society of Cancer Multidisciplinary Diagnosis and Treatment, China Anti-Cancer Association, The Society of Cancer Endocrinology, China Anti-Cancer Association
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Normal and tumor-derived organoids as a drug screening platform for tumor-specific drug vulnerabilities

STAR Protocols, 2022
Summary: Patient-derived tumor organoids can be predictive of patient’s treatment responses, and normal tissue-derived organoids allow for drug toxicity testing.
Camilla Calandrini, Jarno Drost
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Digital image analysis using video microscopy of human-derived prostate cancer vs normal prostate organoids to assess migratory behavior on extracellular matrix proteins

Frontiers in Oncology, 2023
The advent of perpetuating living organoids derived from patient tissue is a promising avenue for cancer research but is limited by difficulties with precise characterization.
Kendra D. Marr, Kendra D. Marr, Natalia A. Ignatenko, Noel A. Warfel, Noel A. Warfel, Ken Batai, Anne E. Cress, Anne E. Cress, Grant R. Pollock, Ava C. Wong, Benjamin R. Lee   +10 more
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Application Progress of Organoids in Colorectal Cancer

Frontiers in Cell and Developmental Biology, 2022
Currently, colorectal cancer is still the third leading cause of cancer-related mortality, and the incidence is rising. It is a long time since the researchers used cancer cell lines and animals as the study subject. However, these models possess various
Lianxiang Luo, Lianxiang Luo, Lianxiang Luo, Yucui Ma, Yilin Zheng, Jiating Su, Guoxin Huang   +6 more
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Genetic characterization of a novel organoid from human malignant giant-cell tumor

Journal of Bone Oncology, 2023
Malignant giant-cell tumors are extremely rare bone sarcomas that transform from conventional giant-cell tumors during long periods of treatment. Owing to their rarity, no further analysis of their molecular pathogenesis exists, and thus, no standard ...
Rie Suzuki, Toru Wakamatsu, Keiichi Yoshida, Yukiko Matsuoka, Haruna Takami, Sho Nakai, Hironari Tamiya, Shigeki Kakunaga, Toshinari Yagi, Ken-ichi Yoshida, Yoshinori Imura, Yoshihiro Yui, Satoru Sasagawa, Satoshi Takenaka   +13 more
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Advances in Tumor Organoids for the Evaluation of Drugs: A Bibliographic Review

Pharmaceutics, 2022
Tumor organoids are defined as self-organized three-dimensional assemblies of heterogeneous cell types derived from patient samples that mimic the key histopathological, genetic, and phenotypic characteristics of the original tumor.
Maritza Londoño-Berrio, Cristina Castro, Ana Cañas, Isabel Ortiz, Marlon Osorio   +4 more
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Systematic evaluation of colorectal cancer organoid system by single-cell RNA-Seq analysis

Genome Biology, 2022
Background Patient-derived organoid culture is a powerful system for studying the molecular mechanisms of cancers, especially colorectal cancer (CRC), one of the most prevalent cancers worldwide. There are two main types of 3D culture methods for colonic
Rui Wang, Yunuo Mao, Wendong Wang, Xin Zhou, Wei Wang, Shuai Gao, Jingyun Li, Lu Wen, Wei Fu, Fuchou Tang   +9 more
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An Organoid-Based Preclinical Model of Human Gastric CancerSummary

Cellular and Molecular Gastroenterology and Hepatology, 2019
Background & Aims: Our goal was to develop an initial study for the proof of concept whereby gastric cancer organoids are used as an approach to predict the tumor response in individual patients.
Nina G. Steele, Jayati Chakrabarti, Jiang Wang, Jacek Biesiada, Loryn Holokai, Julie Chang, Lauren M. Nowacki, Jennifer Hawkins, Maxime Mahe, Nambirajan Sundaram, Noah Shroyer, Mario Medvedovic, Michael Helmrath, Syed Ahmad, Yana Zavros   +14 more
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