Results 11 to 20 of about 6,916,201 (263)

Cost-reduction strategy to culture patient derived bladder tumor organoids [PDF]

Scientific Reports
Organoids as self-organized structure derived from stem cells can recapitulate the function of an organ in miniature form which have developed great potential for clinical translation, drug screening and personalized medicine.
Mahsa Mollapour Sisakht, Fatemeh Gholizadeh, Shirin Hekmatirad, Tokameh Mahmoudi, Saeed Montazeri, Laleh Sharifi, Hamed Daemi, Shahla Romal, Mohammad Hosein Yazdi, Mohammad Ali Faramarzi, Ahmad Reza Shahverdi, Amir Ali Hamidieh   +11 more
doaj   +4 more sources

Advancements in Research and Treatment Applications of Patient-Derived Tumor Organoids in Colorectal Cancer. [PDF]

Cancers (Basel)
Colorectal cancer (CRC) remains a significant health burden globally, being the second leading cause of cancer-related mortality. Despite significant therapeutic advancements, resistance to systemic antineoplastic agents remains an important obstacle, highlighting the need for innovative screening tools to tailor patient-specific treatment. This review
van der Graaff D, Seghers S, Vanclooster P, Deben C, Vandamme T, Prenen H.   +5 more
europepmc   +5 more sources

Applications of patient-derived tumor xenograft models and tumor organoids [PDF]

Journal of Hematology & Oncology, 2020
Patient-derived tumor xenografts (PDXs), in which tumor fragments surgically dissected from cancer patients are directly transplanted into immunodeficient mice, have emerged as a useful model for translational research aimed at facilitating precision ...
Go J. Yoshida
doaj   +3 more sources

Patient‐derived organoids as a preclinical platform for precision medicine in colorectal cancer

Molecular Oncology, 2022
Patient‐derived organoids are being considered as models that can help guide personalized therapy through in vitro anticancer drug response evaluation. However, attempts to quantify in vitro drug responses in organoids and compare them with responses in ...
Young‐Won Cho, Dong‐Wook Min, Hwang‐Phill Kim, Yohan An, Sheehyun Kim, Jeonghwan Youk, Jaeyoung Chun, Jong Pil Im, Sang‐Hyun Song, Young Seok Ju, Sae‐Won Han, Kyu Joo Park, Tae‐You Kim   +12 more
doaj   +2 more sources

Modeling Patient-Derived Glioblastoma with Cerebral Organoids

Cell Reports, 2019
Summary: The prognosis of patients with glioblastoma (GBM) remains dismal, with a median survival of approximately 15 months. Current preclinical GBM models are limited by the lack of a “normal” human microenvironment and the inability of many tumor cell
Amanda Linkous, Demosthenes Balamatsias, Matija Snuderl, Lincoln Edwards, Ken Miyaguchi, Teresa Milner, Batsheva Reich, Leona Cohen-Gould, Andrew Storaska, Yasumi Nakayama, Emily Schenkein, Richa Singhania, Stefano Cirigliano, Tarig Magdeldin, Ying Lin, Gouri Nanjangud, Kalyani Chadalavada, David Pisapia, Conor Liston, Howard A. Fine   +19 more
doaj   +2 more sources

Fine-Needle Aspiration-Based Patient-Derived Cancer Organoids

iScience, 2020
Summary: Patient-derived cancer organoids hold great potential to accurately model and predict therapeutic responses. Efficient organoid isolation methods that minimize post-collection manipulation of tissues would improve adaptability, accuracy, and ...
Anna E. Vilgelm, Kensey Bergdorf, Melissa Wolf, Vijaya Bharti, Rebecca Shattuck-Brandt, Ashlyn Blevins, Caroline Jones, Courtney Phifer, Mason Lee, Cindy Lowe, Rachel Hongo, Kelli Boyd, James Netterville, Sarah Rohde, Kamran Idrees, Joshua A. Bauer, David Westover, Bradley Reinfeld, Naira Baregamian, Ann Richmond, W. Kimryn Rathmell, Ethan Lee, Oliver G. McDonald, Vivian L. Weiss   +23 more
doaj   +2 more sources

Deciphering Breast Tumor Heterogeneity Through Patient-Derived Organoids and Circulating Tumor Cells [PDF]

Journal of Personalized Medicine
Breast cancer is a highly heterogeneous disease, with tumors capable of adapting to shifting conditions, making the development of effective personalized therapies particularly challenging. Patient-derived models, such as patient-derived organoids (PDOs)
Carla L. Alves, Policastro, Benedetta; id_orcid, Nikoline Nissen, Alves, Carla Maria Lourenco; id_orcid, Benedetta Policastro, Nissen, Nikoline   +5 more
core   +3 more sources

Development, Expansion, and Histological Characterization of Patient-Derived Liver Organoids for Drug Screening and Disease Modeling

Bio-Protocol
Organoids are self-organizing 3D tissues representing an innovative technology with interesting implications and potential for the study of tumor biology. They can be developed from fine-needle biopsies or resection material from healthy or tumor tissues.
Silvia De Siervi, Stefania Mantovani, Barbara Oliviero, Mario Mondelli, Martina Di Noia, Cristiana Soldani, Barbara Franceschini, Fabrizio De Luca, Marcello Maestri, Salvatore Corallo, Marco Lolicato, Stefania Cannito, Cristian Turato   +12 more
doaj   +2 more sources

Patient-derived tumor organoids as a platform of precision treatment for malignant brain tumors. [PDF]

Sci Rep, 2022
AbstractMalignant brain tumors consist of malignancies originated primarily within the brain and the metastatic lesions disseminated from other organs. In spite of intensive studies, malignant brain tumors remain to be a medical challenge. Patient-derived organoid (PDO) can recapitulate the biological features of the primary tumor it was derived from ...
Chen CC, Li HW, Wang YL, Lee CC, Shen YC, Hsieh CY, Lin HL, Chen XX, Cho DY, Hsieh CL, Guo JH, Wei ST, Wang J, Wang SC.   +13 more
europepmc   +4 more sources

Patient-derived tumor organoids for new drug development: promises and challenges. [PDF]

Invest New Drugs
The development of antitumor drugs is affected by various unfavorable factors, including long cycles of research and development, large differences in drug efficacy in vivo, and efficacy differences in individuals. Patient-derived tumor organoids (PDTOs), a novel preclinical model in cancer research, are three-dimensional microstructures differentiated
He M, Wu Y, Du F, Wang J, Zhang H, Han J.   +5 more
europepmc   +3 more sources