Results 31 to 40 of about 6,916,201 (263)

Patient-derived tumor organoids: A preclinical platform for personalized cancer therapy. [PDF]

Transl Oncol
Patient-derived tumor organoids (PDTOs) represent a significant advancement in cancer research and personalized medicine. These organoids, derived from various cancer types, have shown the ability to retain the genetic and molecular characteristics of the original tumors, allowing for the detailed study of tumor biology and drug responses on an ...
Taurin S, Alzahrani R, Aloraibi S, Ashi L, Alharmi R, Hassani N.   +5 more
europepmc   +4 more sources

Uncovering cantharidin's mechanism for cholangiocarcinoma treatment using patient-derived tumor organoids. [PDF]

iScience
This study investigates the antitumor efficacy of cantharidin against cholangiocarcinoma (CCA) using patient-derived organoids (PDOs) that faithfully replicate the histological and genomic features of original tumors. Results demonstrate that cantharidin effectively inhibits CCA PDO growth, showing comparable or superior efficacy to conventional ...
Han P, Wang L, Zhu L, Tong W, Liu S, Wang T, Yang T, Li Z, Zhou X, Zhao T, Cui T, Yang L, Wang Z, Zhang Y.   +13 more
europepmc   +3 more sources

Advances in Tumor Organoids for the Evaluation of Drugs: A Bibliographic Review

Pharmaceutics, 2022
Tumor organoids are defined as self-organized three-dimensional assemblies of heterogeneous cell types derived from patient samples that mimic the key histopathological, genetic, and phenotypic characteristics of the original tumor.
Maritza Londoño-Berrio, Cristina Castro, Ana Cañas, Isabel Ortiz, Marlon Osorio   +4 more
doaj   +1 more source

Establishment and Culture of Patient-Derived Breast Organoids

, 2023
Breast cancer is a complex disease that has been classified into several different histological and molecular subtypes. Patient-derived breast tumor organoids developed in our laboratory consist of a mix of multiple tumor-derived cell populations, and ...
Bhatia, Sonam, Russo, Suzanne, Spector, David L, Aggarwal, Disha, Naik, Payal, Disha Aggarwal, Suzanne Russo, David L. Spector, Payal Naik, Sonam Bhatia   +9 more
core   +1 more source

Patient-derived organoids reflect the genetic profile of endometrial tumors and predict patient prognosis [PDF]

, 2021
Background: A major hurdle in translational endometrial cancer (EC) research is the lack of robust preclinical models that capture both inter- and intra-tumor heterogeneity. This has hampered the development of new treatment strategies for people with EC.
Bjørge, Line, Haldorsen, Ingfrid Helene Salvesen, Trovik, Jone, Strand, Elin, Hjelmeland, Marta Espevold, Fonnes, Tina, Stefansson, Ingunn Marie, Stokowy, Tomasz, Srivastava, Aashish, Lien, Hilde, Høivik, Erling Andre, Lien, Hilde Eide, Berg, Hege Fredriksen, Espedal, Heidi, Haldorsen, Ingfrid S., Bozickovic, Olivera, Hoivik, Erling A., Krakstad, Camilla, Stefansson, Ingunn M., Berg, Hege F., Tina Fonnes, Camilla Krakstad, Tomasz Stokowy, Hege F. Berg, Marta Espevold Hjelmeland, Aashish Srivastava, Ingunn M. Stefansson, Hilde Lien, Jone Trovik, Ingfrid S. Haldorsen, Erling A. Hoivik, Elin Strand, Heidi Espedal, Olivera Bozickovic, Line Bjørge   +34 more
core   +1 more source

Systematic evaluation of colorectal cancer organoid system by single-cell RNA-Seq analysis

Genome Biology, 2022
Background Patient-derived organoid culture is a powerful system for studying the molecular mechanisms of cancers, especially colorectal cancer (CRC), one of the most prevalent cancers worldwide. There are two main types of 3D culture methods for colonic
Rui Wang, Yunuo Mao, Wendong Wang, Xin Zhou, Wei Wang, Shuai Gao, Jingyun Li, Lu Wen, Wei Fu, Fuchou Tang   +9 more
doaj   +1 more source

[Patient-derived tumor organoids (or tumoroid), a growing preclinical model for oncology].

Medecine sciences : M/S, 2022
La récente émergence des cultures d’organoïdes tumoraux, ou tumoroïdes, a permis d’enrichir le répertoire des modèles précliniques en oncologie. Très proches de la tumeur dont elles dérivent, ces microtumeurs offrent de nombreuses possibilités en termes de recherche fondamentale, telles que l’étude de la carcinogenèse ou de la chimioré-sistance, de ...
Thorel, Lucie, Florent, Romane, Perréard, Marion, Vincent, Audrey, Poulain, Laurent, Weiswald, Louis-Bastien   +5 more
openaire   +3 more sources

Role of Patient-Derived Models of Cancer in Translational Oncology [PDF]

, 2022
Cancer is a heterogeneous disease. Each individual tumor is unique and characterized by structural, cellular, genetic and molecular features. Therefore, patient-derived cancer models are indispensable tools in cancer research and have been actively ...
Idrisova, K. F., Simon, H.-U., Gomzikova, M. O., K. F. Idrisova, H.-U. Simon, M. O. Gomzikova   +5 more
core   +2 more sources

Multi-omic dataset of patient-derived tumor organoids of neuroendocrine neoplasms. [PDF]

Gigascience, 2023
Abstract Background Organoids are three-dimensional experimental models that summarize the anatomical and functional structure of an organ. Although a promising experimental model for precision medicine, patient-derived tumor organoids (PDTOs) have currently been developed only for a fraction of ...
Alcala N, Voegele C, Mangiante L, Sexton-Oates A, Clevers H, Fernandez-Cuesta L, Dayton TL, Foll M.   +7 more
europepmc   +4 more sources

Patient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment. [PDF]

Cancer Lett
Madorsky Rowdo FP, Xiao G, Khramtsova GF, Nguyen J, Martini R, Stonaker B, Boateng R, Oppong JK, Adjei EK, Awuah B, Kyei I, Aitpillah FS, Adinku MO, Ankomah K, Osei-Bonsu EB, Gyan KK, Altorki NK, Cheng E, Ginter PS, Hoda S, Newman L, Elemento O, Olopade OI, Davis MB, Martin ML, Bargonetti J.   +25 more
europepmc   +2 more sources