Results 41 to 50 of about 6,916,201 (263)
Patient-derived tumor organoids for cancer immunotherapy: culture techniques and clinical application. [PDF]
Invest New DrugsCancer immunotherapy has revolutionized tumor treatment. However, robust and effective testing platforms remain lacking, especially for the selection of the optimized therapy at the patient-specific level. Unlike conventional treatment evaluations, testing platforms for cancer immunotherapy must incorporate not only tumor cells but also the tumor ...Yao N, Jing N, Lin J, Niu W, Yan W, Yuan H, Xiong Z, Hou Q, Qiao X, Liu Q, Cao J, Li N. +11 moreeuropepmc +3 more sourcesThe Anti-Tumor Effect of Nab-Paclitaxel Proven by Patient-Derived Organoids.
OncoTargets and therapy, 2020 Nab-paclitaxel has been widely used in treating breast cancer and pancreatic patients for its low toxicity and high efficiency. However, its role in gastric cancer (GC) remains ambiguous. The aim of our study was to test the anti-tumor activity of nab-paclitaxel using GC patient-derived organoids.By using the organoid culture system, we describe the ...Xiao,Xing, Chen,Wei, Wei,Zhe-Wei, Chu,Wei-Wei, Lu,Xiao-Fang, Li,Bo, Chen,Hong, Meng,Si-Jun, Hao,Teng-Fei, Wei,Ji-Tao, He,Yu-Long, Zhang,Chang-Hua +11 moreopenaire +3 more sourcesAn Organoid-Based Preclinical Model of Human Gastric CancerSummary
Cellular and Molecular Gastroenterology and Hepatology, 2019 Background & Aims: Our goal was to develop an initial study for the proof of concept whereby gastric cancer organoids are used as an approach to predict the tumor response in individual patients.Nina G. Steele, Jayati Chakrabarti, Jiang Wang, Jacek Biesiada, Loryn Holokai, Julie Chang, Lauren M. Nowacki, Jennifer Hawkins, Maxime Mahe, Nambirajan Sundaram, Noah Shroyer, Mario Medvedovic, Michael Helmrath, Syed Ahmad, Yana Zavros +14 moredoaj +1 more sourceProtocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors [PDF]
, 2021 Summary: Tumor organoids and patient-derived orthotopic xenografts (PDOXs) are some of the most valuable pre-clinical tools in cancer research. In this protocol, we describe efficient derivation of organoids and PDOX models from glioma patient tumors. We Klein, Eliane, Georgia Kanli, Kanli, Georgia, Amandine Bernard, Carina Fabian, Oudin, Anaïs, Yahaya A. Yabo, Monika Dieterle, Yabo, Yahaya A, Niclou, Simone Pierrette, Michelucci, Alessandro, Fabian, Carina, Baus, Virginie, Olivier Keunen, May Wantz, Golebiewska, Anna, Barthelemy, Vanessa, Anaïs Oudin, Wantz, May, Anna Golebiewska, Yabo, Yahaya A., Bernard, Amandine, Simone P. Niclou, NICLOU, Simone P., Eliane Klein, Vanessa Barthelemy, Keunen, Olivier, Virginie Baus, Dieterle, Monika, Rolf Bjerkvig, Claire Dording, Dording, Claire, Alessandro Michelucci, Hau, Ann-Christin, Ann-Christin Hau, Bjerkvig, Rolf +35 morecore +1 more sourcePatient-derived glioblastoma organoids reflect tumor heterogeneity and treatment sensitivity
Neuro-Oncology Advances, 2023 Abstract Background Treatment resistance and tumor relapse are the primary causes of mortality in glioblastoma (GBM), with intratumoral heterogeneity playing a significant role. Patient-derived cancer organoids have emerged as a promising model capable of recapitulating tumor heterogeneity.Verduin, Maikel, Hoosemans, Linde, Vanmechelen, Maxime, van Heumen, Mike, Piepers, Jolanda A.F., Astuti, Galuh, Ackermans, Linda, Schijns, Olaf E.MG., Kampen, Kim R., Tjan-Heijnen, Vivianne C.G., de Barbanson, Buys A., Postma, Alida A., Eekers, Danielle B.P., Broen, Martijn P.G., Beckervordersandforth, Jan, Stankova, Katerina, de Smet, Frederik, Rich, Jeremy, Hubert, Christopher G., Gimenez, Gregory, Chatterjee, Aniruddha, Hoeben, Ann, Vooijs, Marc A. +22 moreopenaire +6 more sourcesProstate cancer patient‐derived organoids: detailed outcome from a prospective cohort of 81 clinical specimens [PDF]
, 2021 Patient-derived organoids (PDOs) represent promising preclinical models in various tumor types. In the context of prostate cancer (PCa), however, their establishment has been hampered by poor success rates, which impedes their broad use for translational Melanie Blind, Seifert, Helge, Vlajnic, Tatjana, Rubin, Mark A., Sina Maletti, Bubendorf, Lukas, Cyrill A Rentsch, Clémentine Le Magnen, Garioni, Michele, Tatjana Vlajnic, Maletti, Sina Laura, Pueschel, Heike, Michele Garioni, Zellweger, Tobias, Blind, Melanie, Salvatore Piscuoglio, Tobias Zellweger, Servant, Raphaëlle, Rentsch, Cyrill A, Garofoli, Andrea, Mark A Rubin, Andrea Garofoli, David C Müller, Arnoud J Templeton, Lukas Bubendorf, Raphaëlle Servant, Helge Seifert, Heike Pueschel, Müller, David C, Templeton, Arnoud J, Piscuoglio, Salvatore, Le Magnen, Clémentine +31 morecore +2 more sourcesSemi-Automated Computational Assessment of Cancer Organoid Viability Using Rapid Live-Cell Microscopy
Cancer Informatics, 2022 The creation of patient-derived cancer organoids represents a key advance in preclinical modeling and has recently been applied to a variety of human solid tumor types.Joseph D Buehler, Cylaina E Bird, Milan R Savani, Lauren C Gattie, William H Hicks, Michael M Levitt, Mohamad El Shami, Kimmo J Hatanpaa, Timothy E Richardson, Samuel K McBrayer, Kalil G Abdullah +10 moredoaj +1 more sourceIn silico tumor purity assessment using whole-exome sequencing data and ABSOLUTE, Sequenza and PureCN tools.
, 2023 ABSOLUTE was run with the max.non.clonal parameter set to either 30% or 50%. CRCLM tumors (A) and tumor-derived organoids (B) from 6 patients for whom matching normal DNA was available were analyzed.Luika Timmerman (3848716), Kenzo Hirose (1734214), Robert S. Warren (6941027), Aras N. Mattis (3369539), Kan Toriguchi (6941021), Noura Tbeileh (15194765), Eveliina Karelehto (846308), Carlos Corvera (15194768), Yosuke Kasai (473540), Eric Nakakura (13197792), David B. Donner (14989598) +10 morecore +1 more sourceOrganoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors
Cell Reports, 2021 Summary: Malignant rhabdoid tumors (MRTs) represent one of the most aggressive childhood malignancies. No effective treatment options are available, and prognosis is, therefore, dismal.Camilla Calandrini, Sander R. van Hooff, Irene Paassen, Dilara Ayyildiz, Sepide Derakhshan, M. Emmy M. Dolman, Karin P.S. Langenberg, Marieke van de Ven, Cecilia de Heus, Nalan Liv, Marcel Kool, Ronald R. de Krijger, Godelieve A.M. Tytgat, Marry M. van den Heuvel-Eibrink, Jan J. Molenaar, Jarno Drost +15 moredoaj +1 more sourceEstablishment of Pancreatic Cancer-Derived Tumor Organoids and Fibroblasts From Fresh Tissue.
, 2023 Tumor organoids are three-dimensional (3D) ex vivo tumor models that recapitulate the biological key features of the original primary tumor tissues. Patient-derived tumor organoids have been used in translational cancer research and can be applied to ...Sonia Camaño Páez, Eduardo Lobo, Carolina de la Pinta, Rodríguez Garrote, Mercedes, Marina Cihova, Maria Urbanova, Sánchez, Bárbara Luna, Barreto Melian, Emma, Buocikova, Verona, Sanjuanbenito, Alfonso, Jesús Frutos Díaz-Alejo, Bruno Sainz, Jr., Lechuga, Carmen G, Guerra, Carmen, Julie Earl, Urbanova, Maria, Carmen G. Lechuga, Mercedes Rodríguez Garrote, Carrato, Alfredo, Peter Dubovan, Cihova, Marina, Páez, Sonia Camaño, Alfonso Sanjuanbenito, Bozena Smolkova, Carmen Guerra, Alfredo Carrato, Bárbara Luna Sánchez, Villalón López, Jorge, Romio de la Heras, Estefanía, April-Monn, Simon, de la Pinta, Carolina, Lobo, Eduardo, Emma Barreto Melian, Torres, Ana, Laura Ruiz-Cañas, Verona Buocikova, Smolkova, Bozena, Tomas, Miroslav, Sainz, Bruno, Estefanía Romio de la Heras, Earl, Julie, Dubovan, Peter, Jorge Villalón López, Ana Torres, Ruiz-Cañas, Laura, Simon April-Monn, Miroslav Tomas, Díaz-Alejo, Jesús Frutos +47 morecore +1 more source
