Results 51 to 60 of about 6,916,201 (263)

Patient-derived head and neck cancer organoids allow treatment stratification and serve as a tool for biomarker validation and identification [PDF]

, 2023
Background: Organoids are in vitro three-dimensional structures that can be grown from patient tissue. Head and neck cancer (HNC) is a collective term used for multiple tumor types including squamous cell carcinomas and salivary gland adenocarcinomas ...
Koomen, Mandy, Clevers, Hans, Bas Penning de Vries, Remco de Bree, Hans Clevers, Begthel, Harry, van Es, Robert J.J., Millen, Rosemary, Willems, Stefan M., Harry Begthel, Patricia Doornaert, Geurts, Maarten H., Maurice Zandvliet, Maarten H. Geurts, Rosemary Millen, Robert J.J. van Es, Gobits, Roán, Mandy Koomen, Roán Gobits, Gijs J.F. van Son, Penning de Vries, Bas, Else Driehuis, Lot A. Devriese, Raaijmakers, Cornelis P.J., Stefan M. Willems, de Bree, Remco, De Kort, Willem W.B., Devriese, Lot A., Doornaert, Patricia, van Son, Gijs J.F., Kranenburg, Onno, Cornelis P.J. Raaijmakers, Elias, Sjoerd G., Driehuis, Else, Onno Kranenburg, Sjoerd G. Elias, Willem W.B. De Kort, Zandvliet, Maurice   +37 more
core   +5 more sources

Human liver organoids for disease modeling of fibrolamellar carcinoma

, 2022
Fibrolamellar carcinoma (FLC) is a rare, often lethal, liver cancer affecting adolescents and young adults, for which there are no approved therapeutics. The development of therapeutics is hampered by a lack of in vitro models.
Lalazar, Gadi, Narayan, Nicole J.C., Clevers, Hans, LaQuaglia, Michael P., Requena, David, Ng, Denise, Ramos-Espiritu, Lavoisier, Shebl, Bassem, Wang, Ruisi, Levin, Solomon, Gehart, Helmuth, Simon, Sanford M., Hammond, William J., Saltsman, James A., Torbenson, Michael S., Hans Clevers, Bassem Shebl, Michael S. Torbenson, Nicole J.C. Narayan, Helmuth Gehart, Gadi Lalazar, Lavoisier Ramos-Espiritu, James A. Saltsman, Michael P. LaQuaglia, Denise Ng, Ruisi Wang, Solomon Levin, David Requena, William J. Hammond, Sanford M. Simon   +29 more
core   +1 more source

Establishing patient-derived organoids from human endometrial cancer and normal endometrium

Frontiers in Endocrinology, 2023
Endometrial cancer is the most common gynecologic malignancy in the United States and is one of the few malignancies that had an increasing incidence and mortality rate over the last 10 years.
Arielle Katcher, Arielle Katcher, Brian Yueh, Kadir Ozler, Aaron Nizam, Aaron Nizam, Ariel Kredentser, Ariel Kredentser, Charlie Chung, Marina Frimer, Marina Frimer, Gary L. Goldberg, Gary L. Goldberg, Gary L. Goldberg, Semir Beyaz   +14 more
doaj   +1 more source

Glioblastoma Model Using Human Cerebral Organoids

Cell Reports, 2018
Summary: We have developed a cancer model of gliomas in human cerebral organoids that allows direct observation of tumor initiation as well as continuous microscopic observations.
Junko Ogawa, Gerald M. Pao, Maxim N. Shokhirev, Inder M. Verma   +3 more
doaj   +1 more source

Abstract 992: Patient-derived tumor organoids of neuroendocrine prostate cancer

, 2017
Background: The development of neuroendocrine prostate cancer (NEPC) is one mechanism of treatment resistance to androgen receptor (AR)-targeted therapies for a subset of patients with advanced prostate cancer.
Reid Shaw, Wouter Karthaus, Juan Miguel Mosquera, Yu Chen, Giorgio Inghirami, Dong Gao, Joanna Cyrta, Mark A. Rubin, Himisha Beltran, Carla Grandori, Rachele Rosati, Rohan Bareja, Loredana Puca, Rema Rao, Andrea Sboner, Chantal Pauli   +15 more
core   +1 more source

Supplementary Figure S5 from Effective Reprogramming of Patient-Derived M2-Polarized Glioblastoma-Associated Microglia/Macrophages by Treatment with GW2580

, 2023
pGBM patient-derived tumor organoids maintain cellular composition, extracellular matrix, and proliferative activity of the parental tumor.
Catharina Lotsch (17387784), Christel Herold-Mende (15047946), Maximilian Knoll (9526953), Christine Jungk (17387793), Valentina Fermi (17387778), Philip Dao Trong (17387796), Amélie Wöllner (17387781), Andreas Unterberg (15047943), Rolf Warta (15047940), Lena Jassowicz (17387787), Andreas von Deimling (15037904), Gerhard Jungwirth (15047922), Amir Abdollahi (15026702), Carmen Rapp (17387790)   +13 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Organoids derived from metastatic cancers: Present and future

Heliyon
Organoids are three-dimensional structures derived from primary tissue or tumors that closely mimic the architecture, histology, and function of the parental tissue.
Xuejing Zheng, Xinxin Zhang, Shengji Yu
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Tumor organoid biobank-new platform for medical research

Scientific Reports, 2023
Organoids are a new type of 3D model for tumor research, which makes up for the shortcomings of cell lines and xenograft models, and promotes the development of personalized precision medicine.
Xuexue Xie, Xinyu Li, Wei Song
doaj   +1 more source