Results 71 to 80 of about 35,228 (288)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Fine-Needle Aspiration-Based Patient-Derived Cancer Organoids

iScience, 2020
Summary: Patient-derived cancer organoids hold great potential to accurately model and predict therapeutic responses. Efficient organoid isolation methods that minimize post-collection manipulation of tissues would improve adaptability, accuracy, and ...
Anna E. Vilgelm, Kensey Bergdorf, Melissa Wolf, Vijaya Bharti, Rebecca Shattuck-Brandt, Ashlyn Blevins, Caroline Jones, Courtney Phifer, Mason Lee, Cindy Lowe, Rachel Hongo, Kelli Boyd, James Netterville, Sarah Rohde, Kamran Idrees, Joshua A. Bauer, David Westover, Bradley Reinfeld, Naira Baregamian, Ann Richmond, W. Kimryn Rathmell, Ethan Lee, Oliver G. McDonald, Vivian L. Weiss   +23 more
doaj   +1 more source

in Vitro and in Vivo Models to Decipher Intra-tumor Heterogeneity [PDF]

, 2018
Recent advances in next-generation sequencing and other omics technologies capable to map cell fate provide increasing evidence on the crucial role of intra-tumor heterogeneity (ITH) for cancer progression.
Gaebler, Manuela, Gambara, Guido, Keilholz, Ulrich, Regenbrecht, Christian R. A., Silvestri, Alessandra   +4 more
core   +1 more source

The Anti-Tumor Effect of Nab-Paclitaxel Proven by Patient-Derived Organoids.

OncoTargets and therapy, 2020
Nab-paclitaxel has been widely used in treating breast cancer and pancreatic patients for its low toxicity and high efficiency. However, its role in gastric cancer (GC) remains ambiguous. The aim of our study was to test the anti-tumor activity of nab-paclitaxel using GC patient-derived organoids.By using the organoid culture system, we describe the ...
Xiao,Xing, Chen,Wei, Wei,Zhe-Wei, Chu,Wei-Wei, Lu,Xiao-Fang, Li,Bo, Chen,Hong, Meng,Si-Jun, Hao,Teng-Fei, Wei,Ji-Tao, He,Yu-Long, Zhang,Chang-Hua   +11 more
openaire   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Evaluation of chemotherapy drug efficacy using organoids model of colorectal cancer [PDF]

Jichu yixue yu linchuang
Objective To establish human colorectal cancer(CRC) organoids and to evaluate the efficacy of chemotherapy drugs. Methods Patient-derived CRC cells were cultured to form organoids.
GUO Yuehong, ZHOU Fanqi, WU Xi, ZHANG Guannan, WANG Fang, YU Jia
doaj   +1 more source

3-Dimensional Model to Study Apoptosis Induction of Activated Natural Killer Cells Conditioned Medium Using Patient-Derived Colorectal Cancer Organoids

Frontiers in Cell and Developmental Biology, 2022
Natural killer (NK) cells are innate lymphocytes that can kill tumor cells via different pathways, including the secretion of cytotoxic granules in immunological synapses and the binding of apoptosis-inducing ligands with cognate death receptors on tumor
Benyamin Parseh, Benyamin Parseh, Ayyoob Khosravi, Ayyoob Khosravi, Abdolreza Fazel, Jafar Ai, Somayeh Ebrahimi-Barough, Javad Verdi, Majid Shahbazi   +8 more
doaj   +1 more source

FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes. [PDF]

, 2019
Mutations in the transcription factor FOXA1 define a unique subset of prostate cancers but the functional consequences of these mutations and whether they confer gain or loss of function is unknown1-9. Here, by annotating the landscape of FOXA1 mutations
Adams, Elizabeth J, Barbieri, Christopher E, Bose, Rohit, Chhangawala, Sagar, Cho, Hyunwoo, Davicioni, Elai, DiLoreto, Rose, Gruet, Antoine, Hoover, Elizabeth, Karthaus, Wouter R, Leslie, Christina S, Liu, Deli, Liu, Yang, Sawyers, Charles L, Sboner, Andrea, Watson, Philip A, Zhang, Zeda   +16 more
core   +1 more source

α5β1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site. [PDF]

, 2017
Tumors are fibrotic and characterized by abundant, remodeled, and cross-linked collagen that stiffens the extracellular matrix stroma. The stiffened collagenous stroma fosters malignant transformation of the tissue by increasing tumor cell tension to ...
Cassereau, L, García, AJ, Gooch, KJ, Hannachi, E-I, Miroshnikova, YA, Mouw, JK, Ou, G, Pickup, M, Rozenberg, GI, Sarang-Sieminski, AL, Templeman, KL, Weaver, VM   +11 more
core   +2 more sources

Patient-Derived Tumor Organoid Rings for Histologic Characterization and High-Throughput Screening

STAR Protocols, 2020
Tumor organoids are promising tools for cancer biology investigations and preclinical drug screenings because they are often representative of the histology and drug responses of patients. Here, we introduce a facile protocol to overcome technical limitations by generating patient-derived tumor organoids using a simplified ring-like geometry.
Nguyen, Huyen Thi Lam, Soragni, Alice
openaire   +5 more sources