Results 81 to 90 of about 6,916,201 (263)

Development of primary human pancreatic cancer organoids, matched stromal and immune cells and 3D tumor microenvironment models

BMC Cancer, 2018
Background Patient-derived tumor models are the new standard for pre-clinical drug testing and biomarker discovery. However, the emerging technology of primary pancreatic cancer organoids has not yet been broadly implemented in research, and complex ...
Susan Tsai, Laura McOlash, Katie Palen, Bryon Johnson, Christine Duris, Qiuhui Yang, Michael B. Dwinell, Bryan Hunt, Douglas B. Evans, Jill Gershan, Michael A. James   +10 more
doaj   +1 more source

A simple high-throughput approach identifies actionable drug sensitivities in patient-derived tumor organoids [PDF]

, 2019
Tumor organoids maintain cell–cell interactions, heterogeneity, microenvironment, and drug response of the sample they originate from. Thus, there is increasing interest in developing tumor organoid models for drug development and personalized medicine ...
Memarzadeh, Sanaz, Huang, Jin, Hong, Jenny J, Moatamed, Neda A, Damoiseaux, Robert, Soragni, Alice, Tofig, Bobby, Phan, Nhan, Elashoff, David, Mapua, Matthew   +9 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Evaluation of chemotherapy drug efficacy using organoids model of colorectal cancer [PDF]

Jichu yixue yu linchuang
Objective To establish human colorectal cancer(CRC) organoids and to evaluate the efficacy of chemotherapy drugs. Methods Patient-derived CRC cells were cultured to form organoids.
GUO Yuehong, ZHOU Fanqi, WU Xi, ZHANG Guannan, WANG Fang, YU Jia
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Organoid models established from primary tumors and patient-derived xenograft tumors reflect platinum sensitivity of ovarian cancer patients

BMC Cancer
Background Ovarian cancer (OC) remains the deadliest gynecological cancer, primarily due to late-stage diagnosis and high rates of chemotherapy resistance and recurrence.
Parisa Nikeghbal, Dorsa Zamanian, Danielle Burke, Mara P. Steinkamp   +3 more
doaj   +1 more source

A novel perspective on bone tumors: advances in organoid research

Frontiers in Pharmacology
Bone tumor organoids are three-dimensional cell culture models derived from patient tissues or cells, capable of highly replicating the growth patterns and cell interactions of bone tumors in vitro.
Zebing Ma, Yibing Liu, Rui Chen, Huayu Fan, Liang Kong, Xiangyang Cao, Xiangyang Cao, Xiangyang Cao, Xiangyang Cao, Xiangyang Cao   +9 more
doaj   +1 more source

Plocabulin Displays Strong Cytotoxic Activity in a Personalized Colon Cancer Patient-Derived 3D Organoid Assay

Marine Drugs, 2019
Plocabulin is a novel microtubule-disrupting antitumor agent of marine origin that is currently undergoing phase II clinical trials. Plocabulin has potent antiproliferative and antiangiogenic actions in carcinoma cell lines and has antitumor activity in ...
Alba Costales-Carrera, Asunción Fernández-Barral, Pilar Bustamante-Madrid, Laura Guerra, Ramón Cantero, Antonio Barbáchano, Alberto Muñoz   +6 more
doaj   +1 more source

Selection of the Most Suitable Culture Medium for Patient-Derived Lung Cancer Organoids [PDF]

Introduction: Patient-derived organoids have emerged as a promising in vitro model for precision medicine, particularly in cancer, but also in noncancer-related diseases.
Molins López-Rodó, Laureano, Carrasco, Antonio, Martínez Hernández, Daniel, Altuna Coy, Antonio, Orozco, Juan Pablo, Marrades Sicart, Ramon Ma., Navarro Ponz, Alfons, Ramos Izquierdo, Ricard, Díaz Sánchez, Tania, Acosta Plasencia, Melissa, He, Yangyi, Yang, Tianmiao   +11 more
core   +1 more source