Results 101 to 110 of about 6,916,201 (263)

Hydrogel‐Based Airway‐on‐Tube With Perfusable Endothelial Lumen and Outward Epithelialization

Advanced Materials, EarlyView.
A hydrogel‐based airway‐on‐tube platform featuring a perfusable endothelial lumen and outward epithelialization is presented. The system supports primary human bronchial epithelial and lung microvascular endothelial coculture under air‐liquid interface conditions.
Ali Doryab, Jack F. Murphy, Michael Bartolf‐Kopp, Jenny C‐C Hsin, Alice Chernaik, Frank McCaughan, Yan Yan Shery Huang, Tomasz Jungst, Jürgen Groll   +8 more
wiley   +1 more source

Patient-Derived Tumor Organoid Rings for Histologic Characterization and High-Throughput Screening

STAR Protocols, 2020
Tumor organoids are promising tools for cancer biology investigations and preclinical drug screenings because they are often representative of the histology and drug responses of patients. Here, we introduce a facile protocol to overcome technical limitations by generating patient-derived tumor organoids using a simplified ring-like geometry.
Nguyen, Huyen Thi Lam, Soragni, Alice
openaire   +5 more sources

Patient-Derived Tumor Organoid and Fibroblast Assembloid Models for Interrogation of the Tumor Microenvironment in Esophageal Adenocarcinoma [PDF]

Cell Reports Methods
Abstract The tumor microenvironment (TME) comprises all non-tumor elements of cancer and strongly influences disease progression and phenotype. To understand tumor biology and accurately test new therapeutic strategies, representative models should contain both tumor cells and normal cells of the TME.
Benjamin P. Sharpe, Liliya A. Nazlamova, Carmen Tse, David A. Johnston, Rhianna Blyth, Oliver J. Pickering, Ben Grace, Jack Harrington, Rushda Rajak, Matthew Rose-Zerilli, Zoe S. Walters, Tim J. Underwood   +11 more
openaire   +3 more sources

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Organoids in Cancer Research: Current Applications, Limitations, and Technological Advances

Journal of Chest Surgery
Organoids are 3-dimensional cell culture systems derived from stem cells through self-organization. They recapitulate key aspects of tissue architecture and organ-specific functions, providing a powerful preclinical platform for cancer research.
Sujeong Kim, Se Eun Park, Chanwoo Kim, Jae Yeon Kim, Sang Hyeon Han, Eunkyung Park, Jung Eun Kim, Dohun Kim   +7 more
doaj   +1 more source

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers [PDF]

, 2018
Patient-derived organoids (PDOs) have recently emerged as robust preclinical models; however, their potential to predict clinical outcomes in patients has remained unclear.
Elizabeth C. Smyth, Maria Bali, Rata, M, Mihaela Rata, Sheela Rao, Chanthirika Ragulan, Burke, Rosemary, Vlachogiannis, Georgios, Andrea Lampis, Anguraj Sadanandam, Tunariu, Nina, Naureen Starling, Dowsett, M, Fernández-Mateos, Javier, Burke, R, Smyth, EC, Rao, S, de Bono, Johann, Ian Chau, Eccles, Suzanne, Smyth, Elizabeth C., Alexandra Vatsiou, Lampis, A, Sanna Hulkki-Wilson, Paul Workman, Sansom, Owen J., Robinson, Simon P., Eccles, S, Ragulan, Chanthirika, Eltahir, Zakaria, Chiara Braconi, Eason, K, Hulkki-Wilson, Sanna, Darvish-Damavandi, M, Sansom, Owen J, David Watkins, Sadanandam, A, Khan, Khurum, Fassan, Matteo, Inmaculada Spiteri, Fassan, M, Nicola Valeri, Fotiadis, Nicos, Fotiadis, N, Watkins, D, Suzanne Eccles, Katherine Eason, Khurum Khan, Fernández-Mateos, J, Matteo Fassan, Robinson, SP, Hazel Lote, Hahne, JC, Yann Jamin, Vlachogiannis, G, Vatsiou, A, Hulkki-Wilson, S, Braconi, Chiara, Javier Fernández-Mateos, Spiteri, Inmaculada, Johann de Bono, Vatsiou, Alexandra, Tunariu, N, Sing Yu Moorcraft, Hahne, Jens C, Huntingford, I, Nicos Fotiadis, Eason, Katherine, Chau, I, David Cunningham, Starling, Naureen, Darvish-Damavandi, Mahnaz, Rosemary Burke, Begum, Ruwaida, Sadanandam, Anguraj, Somaieh Hedayat, Mitchell Dowsett, Owen J. Sansom, Andrea Sottoriva, Koh, D-M, Clarke, PA, Sottoriva, A, Robinson, Simon P, Cunningham, David, Koh, Dow-Mu, Workman, P, Lampis, Andrea, Jamin, Y, Chau, Ian, Begum, R, Rata, Mihaela, Hedayat, S, Collins, David, Clarke, Paul A., Watkins, David, Smyth, Elizabeth C, Rao, Sheela, Moorcraft, SY, Georgios Vlachogiannis, Zakaria Eltahir, Bali, M, Jens C. Hahne, Nina Tunariu, Lote, Hazel, Ragulan, C, Cunningham, D, Eltahir, Z, Sansom, OJ, Huntingford, Ian, Ian Huntingford, David Collins, Ruwaida Begum, Valeri, Nicola, Lote, H, de Bono, J, Moorcraft, Sing Yu, Khan, K, Bali, Maria, Collins, D, Braconi, C, Hedayat, Somaieh, Workman, Paul, Starling, N, Spiteri, I, Dowsett, Mitchell, Mahnaz Darvish-Damavandi, Simon P. Robinson, Sottoriva, Andrea, Clarke, Paul A, Jamin, Yann, Paul A. Clarke, Hahne, Jens C., Dow-Mu Koh, Valeri, N   +133 more
core   +1 more source

Mechanoactive Biomaterials for Cell–Matrix Mechanotransduction

Advanced Materials, EarlyView.
The graphical abstract shows how individual triggers (force, light, or temperature) and combined optothermal or receptor‐targeted actuation induce material responses at the tissue, cellular, and receptor scales. Their spatial (global or focused) and temporal (continuous or cyclic) modulation determines the resulting mechanical output.
Yi‐Tung Lu, Alison E. John, Marc A. Fernández‐Yagüe   +2 more
wiley   +1 more source

Optimized Large-Scale Longitudinal Biorepository of Gastroesophageal Adenocarcinoma Patient-Derived Organoids: High-Fidelity Models for Personalized Treatment to Overcome Resistance

Organoids
A major limitation in studying gastroesophageal adenocarcinoma (GEA) has been the lack of reliable models that represent the disease’s complexity. We present lessons learned from a comprehensive large-scale biobanking effort combining traditional sample ...
Mingyang Kong, Sanjima Pal, Shuyuan Wang, Julie Bérubé, Ruoyu Ma, Yifei Yan, Wotan Zeng, France Bourdeau, Betty Giannias, Hong Zhao, Nathan Osman, Yehonatan Nevo, Kulsum Tai, Hellen Kuasne, James Tankel, Gertruda Evaristo, Pierre O. Fiset, Xin Su, Swneke Bailey, Morag Park, Nicholas Bertos, Veena Sangwan, Lorenzo Ferri   +22 more
doaj   +1 more source

A U‐shaped Microfluidic Platform for Culturing Vascularized Colorectal Cancer Spheroids Reveals Tumor–Endothelial Crosstalk and Invasion‐Associated Remodeling

Advanced Materials Technologies, EarlyView.
A closed U‐shaped microfluidic platform symmetrically embeds a single, size‐controlled HT29 colorectal cancer spheroid within a GFP‐HUVEC‐laden fibrin matrix. HT29 spheroids are associated with hyper‐branched endothelial network remodeling, while vascularized co‐culture is accompanied by anisotropic protrusive growth and EMT‐like marker changes in the ...
G. Cretti, M. Ballerini, A. Mantegazza, P. Occhetta, M. Rasponi   +4 more
wiley   +1 more source

In‐House Manufacturing of 3D ECM Culture Chips via Vacuum Thermoforming for Enhanced Imaging Applications

Advanced Materials Technologies, EarlyView.
Desktop vacuum thermoforming enables rapid, low‐cost fabrication of 96‐channel polystyrene culture chips with very thin imaging interfaces. The resulting platform supports cell lines, primary cells, and patient‐derived organoids, and enables high‐resolution confocal microscopy and single‐cell visualization, providing an accessible approach for advanced
Aleksandra Fomina, Adam Tam, Jennifer Lam, Nila C. Wu, Nancy T. Li, Alison P. McGuigan   +5 more
wiley   +1 more source