Results 91 to 100 of about 6,916,201 (263)

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Organoid Culture Using Single-Layer Matrigel Method Recapitulates Cervical Cancer Subtypes In Vitro—A Tool for Precision Medicine Applications

Organoids
Advanced cervical cancer remains a major cause of mortality in women worldwide as it has limited treatment options and recurrence is very common. This highlights the necessity to develop patient-derived organoids (PDOs) as preclinical models that can ...
Surbhi Singla, Rashmi Bagga, Radhika Srinivasan, Prateek Bhatia, Shalmoli Bhattacharyya   +4 more
doaj   +1 more source

Prostate Cancer Patient‐Derived Organoids (PDOs) as Functional Avatars for Antisense Oligonucleotide (ASO)‐Based Personalized Therapy

Advanced Healthcare Materials, EarlyView.
Prostate patient‐derived organoids (PDOs) were established from TURP and biopsy specimens with >90% success and retain key features of their tissues of origin, making them functional avatars for antisense oligonucleotide (ASO) therapy . Transfecting single cells outside the Matrigel matrix and then reconstituting organoids overcomes the 3D delivery ...
Thi Thom Tran, Thi Tu Uyen Phan, Michael Baboudjian, Quang Hieu Duong, Ines Sousa, Thi Thuy Le, Virginie Baylot, Sophie Giusiano, Laurent Daniel, Pauline Brige, Benjamin Guillet, Cyrille Bastide, Carmen Garrido, David Taïeb, Thi Khanh Le, Palma Rocchi   +15 more
wiley   +1 more source

Modeling Early Metastatic Progression in Breast Cancer Using a Barrier‐Free, Perfusable Spheroid‐on‐a‐Chip Platform

Advanced Healthcare Materials, EarlyView.
Open‐port, barrier‐free microfluidic device for modeling early metastatic progression. A centrally positioned tumor spheroid releases invasive cells that migrate through the surrounding matrix and intravasate into endothelialized lateral channels.
Vira Sharko, Claudia Olaizola‐Rodrigo, Clara Bayona, Teodora Ranđelović, Rosa Monge, Estela Solanas, Sara Oliván, Ignacio Ochoa   +7 more
wiley   +1 more source

Tumor organoids in immunotherapy: from disease modeling to translational research

Journal for ImmunoTherapy of Cancer
Tumor organoids have emerged as transformative tools in cancer research, enabling the study of tumor biology and immunology in a physiologically relevant, three-dimensional in vitro environment.
Jing Ma, Jianping Song, Zhuolong Zhou, Qi Si, Shuhan Tao, Jizhun Wu, Zhengxing Li, Xiaohang Feng, Tiantian Kong   +8 more
doaj   +1 more source

The promises and challenges of patient-derived tumor organoids in drug development and precision oncology. [PDF]

Animal Model Exp Med, 2019
AbstractIn the era of precision medicine, cancer researchers and oncologists are eagerly searching for more realistic, cost effective, and timely tumor models to aid drug development and precision oncology. Tumor models that can faithfully recapitulate the histological and molecular characteristics of various human tumors will be extremely valuable in ...
Granat LM, Granat LM, Kambhampati O, Klosek S, Niedzwecki B, Parsa K, Zhang D.   +6 more
europepmc   +5 more sources

AI-Enhanced Patient-Derived Cancer Organoids: Integrating Machine Learning for Precision Oncology

Cancer remains a leading cause of mortality worldwide. Patient-derived organoids (PDOs) are three-dimensional (3D) cultures that recapitulate tumor histology, genetics, and cellular heterogeneity, providing physiologically relevant preclinical models ...
Piraino, Francesco, Heinzelmann, Elisa, Elisa Heinzelmann, Francesco Piraino   +3 more
core   +1 more source

Patient-Derived Cancer Organoids for Precision Oncology Treatment

, 2021
The emergence of three-dimensional human organoids has opened the door for the development of patient-derived cancer organoid (PDO) models, which closely recapitulate parental tumor tissue.
Jeffrey I. Traylor, Samuel K. McBrayer, Cylaina E. Bird, Timothy E. Richardson, Kalil G. Abdullah, Mark N. Pernik, Diana D. Shi   +6 more
core   +1 more source

Bone Organoids Across the Development‐to‐Remodeling Continuum: From Tissue Formation to Functional Competence and Translation

Advanced Healthcare Materials, EarlyView.
Mineralization alone does not establish a mature bone organoid. This Review integrates biological foundations, materials design, adaptive remodeling, and translational validation through the development‐to‐remodeling continuum (DRC). By separating biological functions from the evidence supporting them, the framework exposes critical gaps in current ...
Xijie Tang, Haijia Xu, Xiangzhong Liu, Yi Yang, Zhanghua Li   +4 more
wiley   +1 more source

Establishing a cryopreserved biobank of living tumor tissues for drug sensitivity testing

Bioactive Materials
The cryopreservation of cancer tissues to generate frozen libraries is a common practice used worldwide for storing patient samples for later applications.
Ping Chen, Jing-Bo Zhou, Xiang-Peng Chu, Yang-Yang Feng, Qi-Bing Zeng, Josh-Haipeng Lei, Ka-Pou Wong, Tai-Ip Chan, Chon-Wa Lam, Wen-Li Zhu, Wai-Kuok Chu, Feng Hu, Guang-Hui Luo, Kin-Iong Chan, Chu-Xia Deng   +14 more
doaj   +1 more source