Results 71 to 80 of about 4,801,388 (251)

BRCA1 and BRCA2 mutations and clinical interpretation in 398 ovarian cancer patients: comparison with breast cancer variants in a similar population

Human Genomics, 2018
Background Ovarian cancer is the leading cause of death worldwide among gynecologic malignancies. The recent approval of inhibitors of poly (ADP-ribose) polymerase (iPARP) in the treatment of ovarian cancer in the presence of a BRCA1/2 mutation has ...
Florencia C. Cardoso, Susana Goncalves, Pablo G. Mele, Natalia C. Liria, Leonardo Sganga, Ignacio Diaz Perez, Ernesto J. Podesta, Angela R. Solano   +7 more
doaj   +1 more source

Prospective study of symptoms of ovarian cancer in postmenopausal women [PDF]

, 2010
Background: Research has identified key symptoms of ovarian cancer, although there are gaps in the knowledge about the pattern of symptom onset, severity and frequency. Previous studies are limited by use of non-validated questionnaires, recall bias and
Allen, P.L.
core  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Integrative in silico and experimental identification of non-covalent UBE2N inhibitors enhancing PARP inhibitor sensitivity

European Journal of Medicinal Chemistry Reports
UBE2N, an E2 ubiquitin-conjugating enzyme, has emerged as a promising therapeutic target in oncology due to its critical roles in DNA damage repair and NF-κB signalling.
Côme Ghadi, Shafi Ullah Khan, Léonie Ibazizene, Florian Schwalen, Charline Kieffer, Peggy Suzanne, Julie Jaouen, Hassiba Bouafia, Xavier Thuru, Marie Cornu, Cedric Lecoutey, Matthieu Meryet-Figuiere, Anne Sophie Voisin-Chiret, Louis-Bastien Weiswald, Jana Sopkova-de Oliveira Santos   +14 more
doaj   +1 more source

Ovarian cancer serum biomarker discovery using proteomics [PDF]

, 2008
Ovarian cancer is a lethal gynaecological malignancy which is known as the silent killer. It has a poor prognosis due to the lack of major symptoms in early stage disease and hence its late detection.
Kabir, M.
core  

Fertility preservation for girls and young women with cancer: population-based validation of criteria for ovarian tissue cryopreservation [PDF]

, 2014
Background: Ovarian tissue cryopreservation with later reimplantation has been shown to preserve fertility in adult women, but this approach remains unproven and experimental in children and adolescents.
Edgar, Angela E, Anderson, Richard A, Wallace, W Hamish B, Smith, Alice Grove, Kelsey, Thomas W, Kelsey, T., Wallace, H., Kelsey, Thomas W; id_orcid, Kelsey, T.; id_orcid   +8 more
core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

The cyclin-dependent kinase inhibitor p57(Kip2) is epigenetically regulated in carboplatin resistance and results in collateral sensitivity to the CDK inhibitor seliciclib in ovarian cancer [PDF]

, 2012
Carboplatin remains a first-line agent in the management of epithelial ovarian cancer (EOC). Unfortunately, platinum-resistant disease ultimately occurs in most patients.
Madhuri, K, Giannopoulos, T, P Chivers, D P Lovell, Crook, T, H M Coley, E Papacharalbous, T Giannopoulos, Coley, HM, Butler-Manuel, S, S Butler-Manuel, K Madhuri, Papacharalbous, E, Lovell, DP, N A M Safuwan, Safuwan, NA, T Crook, Chivers, P   +17 more
core   +1 more source

Charge‐Reversed Lipid Nanoparticles Enable Encapsulation of Pt2L4 Nanocages for In vivo Anti‐Cancer Treatment

Advanced Materials, EarlyView.
Charge‐reversed lipid nanoparticles (revLNPs) enable efficient encapsulation and delivery of cationic Pt2L4 nanocages. Encapsulation preserves potent anticancer activity while improving circulation, reducing vascular leakage, and promoting favorable biodistribution in vivo.
Renzo A. Knol, Bochuan Hu, Eduard O. Bobylev, Martina Farber, Petrus C. M. Laan, Thomas J. F. Kock, Bauke Fontein, Johanna Erbani, Oscar Escalona‐Rayo, Seline S. Roose, Tom Keijer, Gabriel Forn‐Cuní, B. Ewa Snaar‐Jagalska, Leila Akkari, Joost N. H. Reek, Alexander Kros, Dennis Aschmann   +16 more
wiley   +1 more source

Exploring Strategies to Prevent and Treat Ovarian Cancer in Terms of Oxidative Stress and Antioxidants

Antioxidants
Oxidative stress is a state of imbalance between the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and the antioxidant defence system in the body.
Yanru Long, Houhui Shi, Jiatian Ye, Xiaorong Qi   +3 more
doaj   +1 more source