Results 171 to 180 of about 215,664 (299)

UBE2O Drives Immune Evasion and Radioimmunotherapy Resistance in Lung Cancer by Degrading CDKL1 to Induce PD‐L1 Transcription

Advanced Science, EarlyView.
UBE2O targets CDKL1 for the degradation to upregulate PD‐L1 expression and promotes resistance to radioimmunotherapy in lung cancer, supporting the potential of targeting UBE2O as a promising therapeutic strategy. ABSTRACT Resistance to radioimmunotherapy is one of the primary causes of treatment failure in lung cancer patients; however, the underlying
Huichan Xue, Xiaohua Jie, Zhiwei Liu, Ruoxin Fang, Shuo Wu, Xiaorong Dong, Shuangbing Xu   +6 more
wiley   +1 more source

Lactate metabolism and lactylation in female reproductive diseases: From metabolic rewiring to biomarkers and translational therapeutics. [PDF]

Clin Transl Med
Qiao J, Xiao Y, Cheng Y, Xu W, Shu J, Li S.   +5 more
europepmc   +1 more source

RBM12 Maintains Glioma Stem Cells by Activating Amino Acid‐Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization

Advanced Science, EarlyView.
This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei, Wenlong Luo, Shu Zhou, Lihao Wan, Peng Ling, Zhihua Huang, Zhihua Qian, Chenfei Lu, Mengyue Guo, Zhen Xue, Jun Qin, Ningwei Zhao, Jianghong Man, Wenchao Zhou, Zhiqiang Dong, Shutong Xu, Zhipeng Zhou, Xiuxing Wang, Weiwei Tao   +18 more
wiley   +1 more source

"OVARIAN DISEASES IN WOMEN AND OVARIAN CANCER"

Macroscopically, ovarian tumors are presented in the form of cystic formations filled with fluid, or in the form of a dense node, reaching various sizes.
Muminova Aziza Takhirovna
core  

Superiority of the ROMA index over HE4 and CA125 for diagnosing ovarian cancer in a Bangladeshi cohort. [PDF]

Clinics (Sao Paulo)
Das PK, Hossain S, Rahman AFMA, Saha P, Ahmed S, Mustakim TM, Tanjim KF, Chowdhury AK, Jishan TR, Tabassum T.   +9 more
europepmc   +1 more source

From Cytoskeletal Remodeling to Oocyte Quality: The Emerging Role of Mechanics

Advanced Science, EarlyView.
Mechanical properties of the oocyte are increasingly recognized as critical determinants of meiotic success and developmental potential. How actomyosin remodeling controls oocyte mechanics, how these properties are altered in pathological conditions, and how they could serve as markers in reproductive medicine are examined.
Anastasia Shihabi, Rose Bulteau, Lucie Barbier, Marie‐Emilie Terret   +3 more
wiley   +1 more source

A diagnosis and treatment algorithm for adnexal masses in female children and adolescents. [PDF]

World J Pediatr Surg
Sun L, Shen J, Chan SSC, Ng K, Zainuddin AA, Stankovic Z, Jayasinghe Y, Grover S, Rahman H, Gao H.   +9 more
europepmc   +1 more source

On the Pathology and Treatment of Ovarian Diseases [PDF]

BMJ, 1874
openaire   +14 more sources

Real‐Time in Vivo Monitoring of Circulating Endometrial Cells: Uncovering Systemic Dissemination and Temporal Fluctuations in Endometriosis

Advanced Science, EarlyView.
A dual‐color pseudo‐menstrual mouse model enables real‐time tracing of circulating endometrial cells (CECs) from uterine and ectopic sources. The study reveals menstrual‐phase‐dependent, burst‐like CEC release, distinct postoperative behaviors of different CEC origins, and a potential association with prolactin fluctuations, providing an in vivo ...
Shang Wang, Chenyu Hou, Buyun Li, Hongyan Cheng, Xue Ye, Honglan Zhu, Yanmin Li, Rui Chen, Sihan Dong, Yi Li, Huiping Liu, Chen Zhang, Rui Zhang, Hongyi Hou, Xunbin Wei, Xiaohong Chang   +15 more
wiley   +1 more source

Inflammasomes meet organoids and artificial intelligence: unraveling the complexity of gynecological inflammation. [PDF]

Front Immunol
Zhang L, Zhao J, Cheng G, Wu J, Liu Y, Lei G, Wang Q.   +6 more
europepmc   +1 more source