Results 61 to 70 of about 307,578 (312)

Expression of activin subunits and receptors in the developing human ovary:activin A promotes germ cell survival and proliferation before primordial follicle formation [PDF]

, 2004
The formation of the essential functional unit of the ovary, the primordial follicle, occurs during fetal life in humans. Factors regulating oogonial proliferation and interaction with somatic cells before primordial follicle formation are largely ...
Bayne, R A L, Cambray, N, Martins da Silva, S J, Hartley, P S, McNeilly, A S, Martins da Silva, S J; id_orcid, Anderson, R A   +6 more
core   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Fractionation of Ovarian Follicles and in vitro Oocyte Maturation and Ovulation Assay of Ciona intestinalis Type A

Bio-Protocol, 2020
Ascidians are the closest living relatives of vertebrates (Delsuc et al., 2006; Satoh et al., 2014) and are important for the evolutionary study of the ovarian follicle development including oocyte maturation and ovulation.
Shin Matsubara, Akira Shiraishi, Tomohiro Osugi, Tsuyoshi Kawada, Honoo Satake   +4 more
doaj   +1 more source

Value of the Ultrasound in the Study of Ovarian Reserve for Prediction of Oocyte Recovery [PDF]

Revista Brasileira de Ginecologia e Obstetrícia, 2016
Purpose To identify which methods used in the assessment of the ovarian reserve are exclusive or complementary to identify the best response to follicle development.
Meire Spressão, Antonio Hélio Oliani, Denise Cristina Mós Vaz Oliani   +2 more
doaj   +2 more sources

Spatially Organized Human Ovarian Spheroids Instruct Endometrial Morphogenesis

Advanced Science, EarlyView.
A spatially organized human follicle‐like spheroid (SPHEGaT) composed of granulosa cells (GCs) and stromal‐derived theca‐like cells (TLCs) establishes sustained steroidogenesis in vitro. When co‐cultured with human endometrial organoids (EMOs), estradiol (E2) and progesterone (P4) exchange induces secretory/progesterone‐responsive differentiation ...
Maria João Sousa, Silke De Vriendt, Lixian Liu, Thalles Fernando Rocha Ruiz, Hugo Vankelecom, Christiani Andrade Amorim   +5 more
wiley   +1 more source

Stem cells in the ovary [PDF]

, 2009
For decades, scientists have thought that female mammals are born with a lifetime supply of oocytes in the ovary, irreversibly destined to decline after birth.
Tomaszczuk-Kossowska, Katarzyna
core   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Expression of the neural cell adhesion NCAM in endocrine cells of the ovary [PDF]

, 1991
In the adult mammalian ovary morphogenesis and differentiation processes are under hormonal control and, thus, occur in a highly regulated way during the sexual cycle.
Lahr, G., Gratzl, Manfred, Mayerhofer, Artur   +2 more
core   +1 more source

SDF‐1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy‐Enhanced Stress Granule Scavenging

Advanced Science, EarlyView.
SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long, Meng Wang, Ruolin Mao, Hong Chen, Juepu Zhou, Xiangfei Wang, Zheng Yuan, Ri‐Cheng Chian, Nan Xiao, Qingsong Xi, Yimin Shu, Lei Jin, Lixia Zhu   +12 more
wiley   +1 more source

The Effects of Ajwa Dates Consumption (Phoenix dactylifera L), on Ovarian Follicular Features with Transvaginal Ultrasound in Perimenopausal Women [PDF]

Advanced Ultrasound in Diagnosis and Therapy
Objective Perimenopause is the transition from the reproductive period to menopause, marked by a decline in the number and function of oocytes. Transvaginal ultrasound is a reliable method for assessing ovarian reserve. Ajwa dates (Phoenix dactylifera L.)
Syahril Erlin, Abdullah Nusratuddin, Ilyas Muhammad, As’ad Suryani, Choridah Lina, Natzir Rosdiana, Kurniawan Liong Boy, Bahar Burhanuddin, Mappaware Nasrudin A., Mulyadi Farah Ekawati, Yacca Susdiaman Sudin
doaj   +1 more source