Results 121 to 130 of about 5,436,969 (234)

The mammalian target of rapamycin protein expression in human granulosa cell tumors

, 2019
Objective: To investigate the role of mammalian target of rapamycin (mTOR) in human granulosa cell ovarian tumors and the therapeutic effect of rapamycin in COV434 mitotic granulosa cell ...
Demikiran, Fuat, Guralp, Onur, Bese, Tugan, Malik, Eduard, Arvas, Macit, İNCE, Ümit, Oktem, Ozgur, Bildik, Gamze, Bese, TEVFİK TUGAN   +8 more
core   +1 more source

Ultrasonography (IOTA‐ADNEX) vs magnetic resonance imaging (ADNEX MR) for diagnosing ovarian cancer in high‐risk patients: a prospective study

Ultrasound in Obstetrics &Gynecology, Volume 68, Issue 5, Page 701-713, November 2026.
ABSTRACT ObjectivesTo systematically validate and compare ultrasonography, using the ultrasound‐based International Ovarian Tumor Analysis – Assessment of Different NEoplasias in the adneXa (IOTA‐ADNEX) model, with magnetic resonance imaging (MRI), using the MRI‐based ADNEX MR scoring system, as second‐line imaging modalities for estimating the risk of
I. M. Dueholm Hjorth, A. Ledger, C. Møller, B. H. Bech, T. Van den Bosch, O. Mogensen   +5 more
wiley   +1 more source

Long Non‐Coding RNAs: Key Regulators of Economic Traits in Livestock From Mechanisms to Breeding Applications

Veterinary Medicine and Science, Volume 12, Issue 6, November 2026.
Long non‐coding RNAs (lncRNAs) act as key regulators of economically important traits in livestock through diverse mechanisms including ceRNA networks, epigenetic regulation (X‐inactivation and imprinting) and liquid–liquid phase separation (LLPS).
Keyvan Khani, Mohammad Taher Harkinezhad, Rahimeh Sepehri   +2 more
wiley   +1 more source

Mechanism study on the regulation of autophagy and oxidative stress through SIRT1/PI3K/AKT pathway by Liuwei Dihuang pill to improve ovarian function

Journal of Ovarian Research
Objective This study aimed to examine the preventive impact of Liuwei Dihuang pill (LWDH) on ovarian injury and to elucidate its mechanism through in vivo and in vitro tests.
Jiawen Zhong, Guoxia Lan, Xiaoqing Ma, Wenyan Zhang, Bo Jiang, Ling Qin, Xiaorong Li, Yan Nian   +7 more
doaj   +1 more source

Pyroptotic Macrophage Extracellular Vesicles Drive miR‐103a‐3p Mediated Mitochondrial Dysfunction in Granulosa Cells in Diminished Ovarian Reserve

Aging Cell, Volume 25, Issue 11, November 2026.
Pyroptotic macrophages release extracellular vesicles enriched in miR‐103a‐3p. These EVs are taken up by granulosa cells, where miR‐103a‐3p targets MFN2 and BCL2L13, disrupting mitochondrial homeostasis and increasing oxidative stress and apoptosis. This EV‐mediated signaling axis contributes to diminished ovarian reserve and represents a potential ...
Wenhan Ju, Xin Xin, Yanli Xiao, Liwen Song, Jinfu Zhang, Shan Xiang   +5 more
wiley   +1 more source

SHP2 improves ovarian morphology and steroidogenic function in a rat PCOS model by modulating IRE1α/XBP1/NLRP3-mediated granulosa cell pyroptosis

Scientific Reports
The specific role and mechanism of SHP2 in polycystic ovary syndrome (PCOS) remain unclear. This study aimed to evaluate the therapeutic potential of SHP2 and elucidate the signaling pathways through which it modulates granulosa cell fate in PCOS. A PCOS
DongXue Wang, JingNa Wang, Bo Yang, Xin Zhao, Xiaoye Feng, Qi Ding, Yuanyuan Wu, LiLi Bao   +7 more
doaj   +1 more source

Malignant Ovarian Granulosa Cell Tumour in a Ewe

, 2008
We describe a rare case of malignant granulosa cell tumour in an adult ewe, euthanised due to progressive weight loss. Necropsy examination revealed a neoplastic enlargement of the right ovary, multifocal neoplastic masses in the lung and spleen, and ...
Polona Juntes, Tanja Švara, Mitja Gombač, Milan Pogačnik   +3 more
core  

Recent advances in polyendocrine metabolic ovarian syndrome, formerly polycystic ovary syndrome, with emphasis on endocrine and metabolic dysfunction and cardiovascular risk

Journal of Internal Medicine, Volume 300, Issue 5, Page 590-609, November 2026.
Abstract Polyendocrine metabolic ovarian syndrome (PMOS), previously known as polycystic ovary syndrome, affects 10%–13% of women of reproductive age and remains underdiagnosed despite its substantial health burden. The introduction of the new PMOS nomenclature in 2026 reflects a fundamental shift in understanding the condition as a lifelong endocrine ...
Maria Forslund, Johanna Melin, Anju E. Joham, Terhi T. Piltonen, D. Aled Rees, Helena J. Teede   +5 more
wiley   +1 more source

Estrogen Receptor Beta Isoforms Interplay Integrates Nuclear and Extra‐Nuclear Signaling to Modulate Human Granulosa Cell Growth

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Working model of ERβ isoform signaling in human granulosa cells. Upon E2 binding, ERβ1 activates ERE‐dependent transcription and represses AP‐1 activity through Jun/Fos interactions. In contrast, ERβ2, ERβ4, and ERβ5 lack E2 binding and ERE activity but promote AP‐1‐dependent transcription and counteract ERβ1 repression, including after phosphorylation
Clémentine Marie, Inza‐Noor Baskaran, Raphaël Corre, Anne Mayeur, Michaël Grynberg, Guillaume Chevreux, David L'Hôte, Joëlle Cohen‐Tannoudji, Stéphanie Chauvin   +8 more
wiley   +1 more source

NR4A1‐Driven Granulosa Cell Ferroptosis Contributes to Obesity‐Related Ovarian Dysfunction and Metformin‐Mediated Ovarian Protection

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Schematic illustrating that NR4A1‐driven granulosa cell ferroptosis mediates obesity‐related ovarian dysfunction, while metformin‐mediated ovarian protection is achieved via suppression of the PI3K/AKT–NR4A1 ferroptotic signaling cascade. ABSTRACT Obesity triggers ovarian dysfunction and female infertility accompanied by granulosa cell damage ...
Huihui Wang, Chaoying Wang, Shuaishuai Guo, Guang Yang, Junnan Fang, Jingyi Hu, Ran Jiang, Jun Zhai, Haixia Jin, Wenyan Song, Senlin Shi, Xianju Huang, Lin Qi, Zhaoting Wu, Yan Liu, Ning Song, Xiangyang Zhang, Guidong Yao   +17 more
wiley   +1 more source