Results 1 to 10 of about 5,004,988 (242)

CNOT6L regulates energy metabolism in the ovarian granulosa cells associated with polycystic ovary syndrome [PDF]

Frontiers in Cell and Developmental Biology
The endocrine functions exerted by ovarian granulosa cells (GCs) are crucial factors in maintaining follicle development, as oocyte development relies on providing energy substrates and cytokines by ovarian granulosa cells.
Shan Han, Shan Han, Yanqiu Xie, Jiale Lv, Xuedong Sun, Yuhua Shi, Yuhua Shi, Yuhua Shi   +7 more
doaj   +3 more sources

DDIT4 is essential for DINP-induced autophagy of ovarian granulosa cells

Ecotoxicology and Environmental Safety, 2023
As one of the most important phthalates, di-isononyl phthalate (DINP) has been widely used as a common plasticizer in the food and personal care products sectors.
Yijing Wang, Si Yang, Chaoju Hao, Jiaxiang Chen, Jinglei Wang, Linlin Xu   +5 more
doaj   +2 more sources

Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression

eLife, 2023
An in vitro model of human ovarian follicles would greatly benefit the study of female reproduction. Ovarian development requires the combination of germ cells and several types of somatic cells.
Merrick D Pierson Smela, Christian C Kramme, Patrick RJ Fortuna, Jessica L Adams, Rui Su, Edward Dong, Mutsumi Kobayashi, Garyk Brixi, Venkata Srikar Kavirayuni, Emma Tysinger, Richie E Kohman, Toshi Shioda, Pranam Chatterjee, George M Church   +13 more
doaj   +1 more source

Circadian clock gene BMAL1 regulates STAR expression in goose ovarian preovulatory granulosa cells

Poultry Science, 2023
: The ovarian circadian clock plays a regulatory role in the avian ovulation-oviposition cycle. However, little is known regarding the ovarian circadian clock of geese. In this study, we investigated rhythmic changes in clock genes over a 48-h period and
Rong Chen, Yifei Qin, Jie Du, Jie Liu, Shudi Dai, Mingming Lei, Huanxi Zhu   +6 more
doaj   +1 more source

Acupuncture regulates the apoptosis of ovarian granulosa cells in polycystic ovarian syndrome-related abnormal follicular development through LncMEG3-mediated inhibition of miR-21-3p

Biological Research, 2023
Background The main features of polycystic ovary syndrome (PCOS) are abnormal follicular development and ovulatory dysfunction, which are caused by excessive apoptosis of ovarian granulosa cells.
Xiaohong Chen, Hengzhen He, Bingcai Long, Binli Wei, Peng Yang, Xiaoying Huang, Qian Wang, Jing Lin, Hongliang Tang   +8 more
doaj   +1 more source

Cangfu Daotan Wan alleviates polycystic ovary syndrome with phlegm-dampness syndrome via disruption of the PKP3/ERCC1/MAPK axis

Journal of Ovarian Research, 2023
Background/Aim Cangfu Daotan Wan (CFDTW) has been widely used for polycystic ovary syndrome (PCOS) patients in the type of stagnation of phlegm and dampness.
Yuan Li, Haicui Wu, Ying Guo, Chaofeng Wei, Lu Guan, Wenhan Ju, Fang Lian   +6 more
doaj   +1 more source

Downregulating lncRNA NEAT1 induces proliferation and represses apoptosis of ovarian granulosa cells in polycystic ovary syndrome via microRNA-381/IGF1 axis

Journal of Biomedical Science, 2021
Objective Researchers have revealed the combined functions of long noncoding RNAs (lncRNAs) and microRNA (miRNAs) in polycystic ovary syndrome (PCOS). This study aimed to understand the role of nuclear-enriched abundant transcript 1 (NEAT1) and miR-381 ...
Jingran Zhen, Jiangli Li, Xia Li, Xue Wang, Yaling Xiao, Zhengyi Sun, Qi Yu   +6 more
doaj   +1 more source

Expression of Angiopoietin 2 in ovarian follicles of crossbred Malabari goat [PDF]

Journal of Veterinary and Animal Sciences, 2023
Angiopoietin-2 (Ang-2) is a local ovarian growth factor belonging to the angiopoietin/Tie (tyrosine kinase with Ig and EGF homology domains) signalling pathway, one of the main pathways involved in ovarian follicular angiogenesis.
M.S. Adithian, V. Babitha, R. Uma, I. S. Sajitha, E. S. Navya   +4 more
doaj   +1 more source

ERK1/2-SOX9/FOXL2 axis regulates ovarian steroidogenesis and favors the follicular–luteal transition

Life Science Alliance, 2023
ERK1/2 negatively regulates estradiol synthesis while positively regulating progesterone production in ovarian granulosa cells via the ERK1/2-SOX9/FOXL2 axis. Estradiol and progesterone are the primary sex steroids produced by the ovary. Upon luteinizing
Vijay Simha Baddela, Marten Michaelis, Xuelian Tao, Dirk Koczan, Jens Vanselow   +4 more
doaj   +1 more source

Di-isononyl phthalate induces apoptosis and autophagy of mouse ovarian granulosa cells via oxidative stress

Ecotoxicology and Environmental Safety, 2022
Di-isononyl phthalate (DINP) has been widely utilized in industrial, commercial and medical applications for the past few years. Therefore, more attention should be paid to the toxicity of DINP.
Jie Chen, Si Yang, Bingchun Ma, Jinglei Wang, Jiaxiang Chen   +4 more
doaj   +1 more source