Results 41 to 50 of about 49,951 (251)

Transcriptome datasets of ESR2-regulated genes in rat granulosa cells during gonadotropin-induced follicle maturation

Data in Brief, 2020
Disruption of estrogen receptor beta (ESR2) dysregulates granulosa cell genes essential for follicle maturation and ovulation. The datasets presented in this article depict gonadotropin-induced genes, which are differentially expressed in Esr2-null rat ...
V. Praveen Chakravarthi, Subhra Ghosh, Eddie Dai, Devansh Pathak, M.A. Karim Rumi   +4 more
doaj   +1 more source

FSH regulates acetycholine production by ovarian granulosa cells [PDF]

Reproductive Biology and Endocrinology, 2006
It has been previously shown that cultured granulosa cells (GCs) derived from human ovarian preovulatory follicles contain choline acetyltransferase (ChAT), the enzyme responsible for acetylcholine (ACh) synthesis. They also produce ACh and express functional muscarinic ACh receptors. ACh can act on GCs to increase proliferation, disrupt gap junctional
Mayerhofer, Artur, Kunz, Lars, Krieger, Annette, Proskocil, Becky, Spindel, Eliot, Amsterdam, Abraham, Dissen, Gregory A., Ojeda, Sergio R., Wessler, Ignaz   +8 more
openaire   +4 more sources

A regulatory network controlling ovarian granulosa cell death

Cell Death Discovery, 2023
AbstractFollicular atresia triggered by granulosa cell (GC) apoptosis severely reduces female fertility and accelerates reproductive aging. GC apoptosis is a complex process regulated by multiple factors, regulatory axes, and signaling pathways. Here, we report a novel, small regulatory network involved in GC apoptosis and follicular atresia.
Liu Yang, Xing Du, Siqi Wang, Chenggang Lin, Qiqi Li, Qifa Li   +5 more
openaire   +3 more sources

LIPUS combined with TFSC alleviates premature ovarian failure by promoting autophagy and inhibiting apoptosis

Gynecological Endocrinology, 2023
Objective Premature ovarian failure (POF), also known as primary ovarian insufficiency, is a major cause of infertility in female worldwide. Excessive apoptosis and impaired autophagy in ovarian granulosa cells are the main pathological mechanisms of POF.
Weimei Zhou, Aixue Chen, Yongju Ye, Yuefang Ren, Jiali Lu, Feilan Xuan, Ruiying Jin   +6 more
doaj   +1 more source

Nuclear Receptor Profiling of Ovarian Granulosa Cell Tumors [PDF]

Hormones and Cancer, 2011
Granulosa cell tumors of the ovary (GCT) represent ~5% of malignant ovarian tumors. The adult form is defined by a mutation in the FOXL2 gene. GCT exhibit many of the features of normal proliferating granulosa cells. We have profiled the expression of the 48 human nuclear receptors (NR) by quantitative RT-PCR in a panel of GCT and in two GCT-derived ...
Alexiadis, Maria, Eriksson, Natalie, Jamieson, Stacey, Davis, Melissa, Drummond, Ann E., Chu, Simon, Clyne, Colin D., Muscat, George E., Fuller, Peter J.   +8 more
openaire   +3 more sources

Species-specific differences in follicular antral sizes result from diffusion-based limitations on the thickness of the granulosa cell layer

, 2013
The size of mature oocytes is similar across mammalian species, yet the size of ovarian follicles increases with species size, with some ovarian follicles reaching diameters more than 1000-fold the size of the enclosed oocyte.
Bächler, M., De Geyter, Ch., Iber, D., Menshykau, D.   +3 more
core   +1 more source

Peripheral and central mechanisms involved in hormonal control of male and female reproduction [PDF]

, 2016
Reproduction involves the integration of hormonal signals acting across multiple systems togenerate a synchronized physiological output. A critical component of reproduction is the luteinizinghormone (LH) surge, which is mediated by estradiol (E2) and ...
Bentley, G. E., Calandra, Ricardo Saul, Micevych, P. E., Paredes, A. H., Rudolph, L. M., Tesone, Marta, Wu, T. J.   +6 more
core   +1 more source

Telomere length in granulosa cells and leukocytes: a potential marker of female fertility? A systematic review of the literature

Journal of Ovarian Research, 2020
In the context of a continuously increased delay of motherhood and of an increase of the incidence of premature ovarian failure, it is of the greatest interest to dispose of a predictive marker of the duration of the fertility window.
Anne-Julie Fattet, Simon Toupance, Simon N. Thornton, Nicolas Monnin, Jean-Louis Guéant, Athanase Benetos, Isabelle Koscinski   +6 more
doaj   +1 more source

The molecular mechanism of ovarian granulosa cell tumors [PDF]

Journal of Ovarian Research, 2018
Over these years, more and more sex cord-stromal tumors have been reported. Granulosa cell tumor (GCT) is a rare tumor in ovaries, accounts for 2% to 5% of ovarian cancers. The main different feature of GCTs from other ovarian cancers is that GCTs can lead to abnormally secreted hormones (estrogen, inhibin and Müllerian inhibiting substance).
Jiaheng Li, Riqiang Bao, Shiwei Peng, Chunping Zhang   +3 more
openaire   +3 more sources

The adipokines progranulin and omentin – novel regulators of basic ovarian cell functions

Reproductive Biology and Endocrinology
The present study aimed to examine the effects of progranulin and omentin on basic ovarian cell functions. For this purpose, we investigated the effects of the addition of progranulin and omentin (0, 0.1, 1, or 10 ng/ml) on the viability, proliferation ...
Alexander V Sirotkin, Zuzana Fabová, Barbora Loncová, Maria Bauerová, Abdel Halim Harrath   +4 more
doaj   +1 more source