Results 61 to 70 of about 5,004,988 (242)

RETRACTED ARTICLE: MiR-140 targets RAP2A to enable the proliferation of insulin-treated ovarian granulosa cells

Journal of Ovarian Research, 2020
Background We elucidated the role of specific MicroRNAs (miRNAs) in the development of polycystic ovary syndrome (PCOS) and explained the changes in the proliferation of granulosa cells. Excised ovarian cortex specimens were collected for miRNA profiling
Zhengfang Xiong, Bing Li, Wenjuan Wang, Xianghui Zeng, Binye Li, Shengyan Jian, Liyun Wang   +6 more
doaj   +1 more source

Conserved SERPINE2 function maintains ovarian estrogen production to support fertility in goats and mice

iMetaOmics, EarlyView.
Single‐nucleus RNA sequencing and functional profiling of goat ovaries with divergent litter sizes revealed prolificacy‐associated granulosa cell (GC) states characterized by enhanced proliferation‐ and steroidogenesis‐related features, together with altered predicted cell–cell communication.
Sanbao Zhang, Yirong Wei, Xiaoping Guo, Ruimen Zhang, Yingming Wei, Yanna Huang, Qinyang Jiang   +6 more
wiley   +1 more source

Role of COX-2/PGE2 signaling pathway in the apoptosis of rat ovarian granulosa cells induced by MEHP

Ecotoxicology and Environmental Safety, 2023
Objective: MEHP, as the metabolite of DEHP, is a widely used environmental endocrine disruptor. Ovarian granulosa cells participate in maintaining the function of ovary and COX2/PGE2 pathway may regulate the function of granulosa cells.
Xu Li, Ying Zhu, Tianyang Zhao, Xueting Zhang, Honghao Qian, Jia Wang, Xiaohan Miao, Liting Zhou, Na Li, Lin Ye   +9 more
doaj   +1 more source

Lactobacillus johnsonii attenuates ovarian aging by remodeling the gut–ovary axis

iMetaOmics, EarlyView.
Aging is accompanied by a reduced abundance of L. johnsonii and ovarian decline. Supplementation with L. johnsonii elevates microbial IPA production via the LdhA enzyme and commensal bacteria. IPA activates the AhR/YAP signaling axis, promoting YAP nuclear translocation and inducing the expression of downstream target genes CYR61 and CTGF. This cascade
Jiamin He, Qiwen Wang, Luyi Chen, Yadong Qi, Dingjiacheng Jia, Jilei Xu, Qingyi Wang, Yao Jiang, Jian Zhou, Yong Sun, Ruochen Yan, Lan Wang, Tongyao Hou, Zheng Kuang, Min Jin, Liangjing Wang, Shujie Chen   +16 more
wiley   +1 more source

The Role of High Cxcl11 Expression in Ovarian Dysfunction Through NF‐κB and AKT Pathways in a Thin Endometrium Mouse Model

iNew Medicine, EarlyView.
Thin endometrium upregulates Cxcl11, which polarizes ovarian macrophages via NF‐κB/AKT, impairing ovarian function. A new uter‐ovarian signaling axis is identified. ABSTRACT Objective Thin endometrium (TE) is a recognized cause of female infertility, primarily associated with impaired uterine receptivity.
Yulu Yang, Fei Tang, Zihan Meng, Yunxi Bao, Jujun Han, Xiaohua Jiang, Jianye Wang, Ying Wang, Zhaolian Wei   +8 more
wiley   +1 more source

Germ cells are not required to establish the female pathway in mouse fetal gonads. [PDF]

PLoS ONE, 2012
The fetal gonad is composed of a mixture of somatic cell lineages and germ cells. The fate of the gonad, male or female, is determined by a population of somatic cells that differentiate into Sertoli or granulosa cells and direct testis or ovary ...
Danielle M Maatouk, Lindsey Mork, Ashley Hinson, Akio Kobayashi, Andrew P McMahon, Blanche Capel   +5 more
doaj   +1 more source

Paracrine effects of oocyte secreted factors and stem cell factor on porcine granulosa and theca cells in vitro [PDF]

, 2003
Oocyte control of granulosa and theca cell function may be mediated by several growth factors via a local feedback loop(s) between these cell types. This study examined both the role of oocyte-secreted factors on granulosa and thecal cells, cultured ...
Hunter, M.G., Brankin, V., Mitchell, M.R., Webb, B.   +3 more
core  

Catecholamine uptake, storage, and regulated release by ovarian granulosa cells

, 2008
Catecholamines present in the mammalian ovary are involved in many normal aspects of ovarian functions, including initial follicle growth, steroidogenesis, and pathological states such as polycystic ovary syndrome.
Paredes Vargas, Alfonso, Greiner, Monika, Rey Ares, Verónica, Saller, Sabine, Lara Peñaloza, Hernán, Mayerhofer, Artur, Paredes, Alfonso, Rey-Ares, Veronica, Lara, Hernan E.   +8 more
core   +1 more source

Nanoplastics: Methods, Exposure and Effects on Domestic, Farm and Wild Animals

Journal of Applied Toxicology, EarlyView.
ABSTRACT Nanoplastics (NPs) are synthetic polymer particles ranging in size from 1 nm to 1 μm that have been identified as a major concern for ecosystems and organisms due to their plethora of negative effects. The aim of this review is to provide a comprehensive overview of the knowledge relating to exposure and effects of NPs in domestic (i.e., farm ...
B. De Felice, M. Bertazzo, A. F. Tabaran, M. Parolini, R. P. Popa, A. Pintea, L. J. Spicer, A‐L. Nagy, F. Caloni   +8 more
wiley   +1 more source

Human mesenchymal stem cells derived exosomes improve ovarian function in chemotherapy-induced premature ovarian insufficiency mice by inhibiting ferroptosis through Nrf2/GPX4 pathway

Journal of Ovarian Research
Background Chemotherapy exposure has become a main cause of premature ovarian insufficiency (POI). This study aimed to evaluate the role and molecular mechanism of human umbilical cord mesenchymal stem cell-derived exosomes (hUMSC-Exos) in ovarian ...
Yuan Zhou, Jinfa Huang, Lingling Zeng, Qian Yang, Fangjuan Bai, Qiqing Mai, Kaixian Deng   +6 more
doaj   +1 more source