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Granulosa Cell Apoptosis in the Ovarian Follicle—A Changing View [PDF]
Frontiers in Endocrinology, 2018 Recent studies challenge the previous view that apoptosis within the granulosa cells of the maturing ovarian follicle is a reflection of aging and consequently a marker for poor quality of the contained oocyte. On the contrary, apoptosis within the granulosa cells is an integral part of normal development and has limited predictive capability regarding
Frank Arfuso +2 more
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Ovarian Juvenile Granulosa Cell Tumors in Infants
Journal of Pediatric Hematology/Oncology, 2009Juvenile ovarian granulosa cell tumors (JGCTs) are described infrequently in pediatrics, and their finding in prepubertal patients is exceptional. Most of the tumors are benign, but recurrences up to 4 years of follow-up have been described. We present 2 cases of JGCT in infants: 1 with late recurrence of bilateral ovarian JGCT and 1 in a newborn with ...
Moisés, Leyva-Carmona +2 more
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The effect of obestatin on porcine ovarian granulosa cells
Animal Reproduction Science, 2008The aim of our in vitro experiments was to investigate the role of obestatin, a newly discovered metabolic hormone produced in the stomach and other tissues, in the direct control of ovarian cell proliferation, apoptosis and secretion. Porcine granulosa cells were cultured in the presence of obestatin (0, 1, 10 and 100ng/ml medium).
M, Mészárosová +4 more
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OVARIAN GRANULOSA CELL TUMOR AND ACROMEGALY
The Journal of Clinical Endocrinology & Metabolism, 1949AMENORRHEA is one of the most consistent and usually one of the earliest symptoms of pituitary tumor in women. Menstrual function may return, however, even after a prolonged period of amenorrhea, following surgical removal of the tumor, its shrinkage by roentgen irradiation, or possibly in rare instances following the escape of the expanding tumor from
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Emerging biomarkers in ovarian granulosa cell tumors
International Journal of Gynecological Cancer, 2019Although the majority of ovarian granulosa cell tumors can be successfully managed with surgery, a subset require chemotherapy for residual and recurrent disease. The benefit of chemotherapy in this population, however, remains controversial. There is therefore interest in the development of more tolerable and effective treatment options for advanced ...
Anne M, Mills +6 more
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The distribution of actin in cultured ovarian granulosa cells
American Journal of Anatomy, 1983AbstractOvarian granulosa cells grown on glass coverslips were split by a “sandwich” technique. Using this technique we describe a complex filamentous network in the cytoplasm of cultured granulosa cells that was composed of a branching and anastomosing lattice of filaments 20–40 nm in diameter.
B E, Batten, E, Anderson
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Effect of Doxorubicin-Induced Ovarian Toxicity on Mouse Ovarian Granulosa Cells
Regulatory Toxicology and Pharmacology, 2017The objective of this study was to identify the effect of doxorubicin-induced ovarian toxicity on mouse ovarian granulosa cells. After granulosa cells were treated with doxorubicin at the final concentrations of 0, 0.4, 0.8, and 1.6 μg/ml for 24 h, cell apoptosis was detected by DAPI staining or caspase-3/7 fluorescence probe; ROS was determined by 2',
Ting Zhang
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Coordinated Receptor Regulation in Ovarian Granulosa Cells
1987The concept of receptor down regulation by its own hormone through internalization of the hormone-receptor complex is well established (for reviews, see Blecher and Bar, 1981; Kaplan, 1981). However, the cellular basis for heterologous receptor regulation is less well defined.
T T, Chen +3 more
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Ovarian granulosa cell proliferations of pregnancy: A report of nine cases
Human Pathology, 1988Granulosa cell proliferations that simulated small neoplasms were incidental findings in the ovaries of nine pregnant women. The lesions were typically multiple and associated with atretic follicles. In eight cases, the granulosa cells were arranged in solid, insular, microfollicular, and trabecular patterns, but in the ninth case, there was a ...
P B, Clement, R H, Young, R E, Scully
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Ovarian juvenile granulosa cell tumors
Adolescent and Pediatric Gynecology, 1990Abstract Ovarian neoplasms, though rarely seen in children or adolescents, are very important biologically due to their potential to affect growth, development, and fertility in these patients; therefore, prompt diagnosis is imperative. Ovarian juvenile granulosa cell tumors (JGCT) occur predominantly in the first two decades of life.
Charles V. Biscotti +1 more
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