Results 111 to 120 of about 170,341 (384)
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Clinico-Immunohistochemical Analysis of Ovarian Tumors in a South Indian Population: A Single-Center Study [PDF]
Journal of Clinical and Basic Research, 2022 Background and objectives: In India, ovarian tumors are the fifth leading cause of death in women. They account for 6% of all cancers in women. The present study aimed to provide support for a new theory of ovarian carcinogenesis by investigating the ...
Venkata Hari Charan Bagadi +3 more
doaj
Fertility preservation in ovarian tumours [PDF]
, 2018 A considerable number of patients with a cancer diagnosis are of childbearing age and have not satisfied their desire for a family. Despite ovarian cancer (OC) usually occurring in older patients, 3%–14% are diagnosed at a fertile age with the overall 5 ...
Bardhi, E. +8 more
core +1 more source
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
, 2016 Retrospective studies indicate that the use of regional anesthesia can reduce cancer recurrence after surgery which could be due to ranging from immune function preservation to direct molecular mechanisms.
Chen, L +5 more
core +3 more sources
Borderline mucinous ovarian tumour – a rare bilateral presentation [PDF]
, 2016 Surface epithelial tumours are the most common ovarian tumours. According to the cell type, surface epithelial tumours can be serous, mucinous, endometrioid etc.
Khan, Nigar Fatema M. +3 more
core +2 more sources
Statistical approaches using longitudinal biomarkers for disease early detection: A comparison of methodologies [PDF]
arXiv, 2019 Early detection of clinical outcomes such as cancer may be predicted based on longitudinal biomarker measurements. Tracking longitudinal biomarkers as a way to identify early disease onset may help to reduce mortality from diseases like ovarian cancer that are more treatable if detected early.
arxiv
CINs of the cytoplasm: dissecting dsRNA signaling in chromosomal instability
Molecular Oncology, EarlyView.Micronuclei, formed during cell division in chromosomal instability settings, rupture and lead to the accumulation of immunogenic double‐stranded RNA in the cytoplasm, activating MAVS‐dependent interferon signaling and innate antitumor immunity.
Aglaia Skolariki +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source
Journal of Rawalpindi Medical College, 2019 Background: Ovarian cancer is the 6th most common cancer in females in USA. The purpose of this study is to determine the distribution of histopathological types of ovarian cancers in different age groups of females to provide an institutional experience.
Fazeelat Iftikhar +4 more
doaj