Results 71 to 80 of about 284,481 (355)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Mucinous Cystic Neoplasm of the Pancreas is Not an Aggressive Entity [PDF]

, 2014
Objective: Mucinous cystic neoplasms (MCNs) of the pancreas have often been confused with intraductal papillary mucinous neoplasms. We evaluated the clinicopathologic characteristics, prevalence of cancer, and prognosis of a large series of well ...
Bassi, Claudio, Capelli, Paola, Castillo, Carlos Fernández-del, Crippa, Stefano, Domínguez, Ismael, Falconi, Massimo, Lauwers, Gregory Y., Mino-Kenudson, Mari, Pederzoli, Paolo, Salvia, Roberto, Thayer, Sarah P., Warshaw, Andrew Louis, Zamboni, Giuseppe   +12 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

To Study Clinicopathological Spectrum of Ovarian Tumour and Tumour Like Lesions in a Tertiary Health Care Centre of North India

JK Science, 2023
Introduction: Variety of primary ovarian neoplasms reflects the complex function of the ovary. The study was conducted to know distribution of ovarian lesions, analyse their mode of presentation and distribution of various morphological pattern of ...
Surbhi Mahajan, Deepti Gupta, Aishvarya Jandial, Subhash Bhardwaj   +3 more
doaj  

Alfa-fetoprotein secreting ovarian sex cord-stromal tumor

Indian Journal of Pathology and Microbiology, 2013
Ovarian sex cord-stromal tumors are relatively infrequent neoplasms that account for approximately 8% of all primary ovarian tumors. They are a heterogeneous group of neoplasms composed of cells derived from gonadal sex cords (granulosa and Sertoli cells)
Kusum D Jashnani, Chandrashekar V Hegde, Shrutika P Munot   +2 more
doaj   +1 more source

Use of novel serum markers in clinical follow-up of Sertoli-Leydig cell turnours [PDF]

, 2007
Background: Sertoli-Leyclig cell tumours of the ovary account for only 0.2% of malignant ovarian tumours. Two-thirds of all patients become apparent due to the tumour's hormone production. Methods: A 41-year-old patient (gravida 4, para 4) presented with
Campisi P, Ching B, Clinton CW, Dhont M, Emons G, Gershenson DM, O'Hern TM, Prinz RA, Schwartz PE, Tampakoudis P, Young RH, Young RH, Zaloudek C   +12 more
core   +2 more sources

A Recurrent Mucinous Neoplasm Originating From an Ovarian Mucinous Cystadenoma After an Adnexectomy As the First Procedure: A Case Report [PDF]

, 2022
Satoshi Ohira, Akiko Hayashi, Reika Kitano, Kyoko Tanaka, Fumiaki Kitamura   +4 more
openalex   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Study of histopathological spectrum of ovarian tumors in a tertiary care hospital in India

MGM Journal of Medical Sciences
Background: Ovarian tumors rank as the third leading cause of mortality among female genital tract malignancies. This study examined the histopathological spectrum of ovarian neoplasms based on our center’s 2020 World Health Organization (WHO ...
Mahalakshmi Subramaniyan, Arathi Shrinivas, Vidya Hasabi, Anne Mary, Purushotham Reddy   +4 more
doaj   +1 more source

Low-Grade Appendiceal Mucinous Neoplasm Involving the Endometrium and Presenting with Mucinous Vaginal Discharge. [PDF]

, 2016
Primary appendiceal mucinous lesions are uncommon and represent a spectrum from nonneoplastic mucous retention cysts to invasive adenocarcinoma. Low-grade appendiceal mucinous neoplasms (LAMNs) represent an intermediate category on this spectrum and can ...
Baumgartner, Joel M, Ko, Albert, Saenz, Cheryl C, Valasek, Mark A, Vavinskaya, Vera   +4 more
core   +4 more sources