Results 51 to 60 of about 12,754 (124)

KAT6A–inhibitor co‐crystal structures: tackling a challenging crystallization target via two alternative approaches

Acta Crystallographica Section D, Volume 82, Issue 9, Page 1111-1124, September 2026.
We report a novel cysteine‐to‐serine surface‐mutation approach to determine co‐crystal structures of KAT6A with small‐molecule inhibitors and compare it with the previously published MYSTcryst approach which uses mutated KAT8 as a surrogate for KAT6A.
Vera Puetter, Léa Bouché, Katrin Nowak-Reppel, Steven J. Ferrara, Stefan N. Gradl, Daniel Korr, Craig A. Strathdee, Antonius ter Laak, Roman C. Hillig   +8 more
wiley   +1 more source

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, Volume 117, Issue 3, Page 642-652, September 2026.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

Pattern of Ovarian Pathologies

Journal of Rawalpindi Medical College, 2013
Background: To study frequency and pattern of ovarian pathologies. Methods: In this descriptive study patients with ovarian lesions were included. Specimen were saved in formalin and histopathological examination was performed. Results: Amongst the total
Javed Iqbal
doaj  

Ovarian malignancy in a patient with Herlyn–Werner–Wunderlich syndrome: A rare clinical presentation

Philippine Journal of Obstetrics and Gynecology
Herlyn–Werner–Wunderlich Syndrome (HWWS) is a rare congenital Mullerian duct anomaly, characterized by the presence of an obstructed hemivagina with uterus didelphys and an ipsilateral renal anomaly (OHVIRA).
Gilana Abinales Gonzales, Aubrey Y. Señeris   +1 more
doaj   +1 more source

Pathological Features of Ovarian Tumors, Diagnosed at a Tertiary Care Hospital in Afghanistan: A Cross-sectional Study

Cancer Management and Research, 2022
Abdul Sami Ibrahimkhil, Haider Ali Malakzai, Ahmed Maseh Haidary, Nasrin Hussaini, Jamshid Abdul-Ghafar Department of Pathology and Clinical Laboratory, French Medical Institute for Mothers and Children (FMIC), Kabul, AfghanistanCorrespondence: Jamshid ...
Ibrahimkhil AS, Malakzai HA, Haidary AM, Hussaini N, Abdul-Ghafar J   +4 more
doaj  

RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF‐β signaling

The FEBS Journal, Volume 293, Issue 17, Page 5340-5362, September 2026.
TGF‐β signaling regulates extracellular vesicle (EV) release in cancer cells by modulating the expression and activity of genes associated with EV biogenesis. The TGF‐β‐induced upregulation of RAB4A expression facilitates fast endosomal recycling, a process that limits the fusion of multivesicular bodies with the plasma membrane and EV secretion. Hence,
Dorival Mendes Rodrigues‐Junior, Maria Anastasia Doumani, Hao Fu, Jelle van den Bor, Olof Idevall‐Hagren, Aristidis Moustakas   +5 more
wiley   +1 more source

Comprehensive Pan‐Cancer Analysis of ABCA1: Insights From Multi‐Omics Data and Exploratory Validation in Esophageal Squamous Cell Carcinoma

Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT Cancer remains a major cause of global mortality, necessitating the identification of novel biomarkers to improve prognosis and guide therapy. ABCA1, an ATP‐binding cassette transporter involved in cholesterol efflux, has been implicated in tumorigenesis, yet its pan‐cancer roles and clinical relevance are not fully understood.
Chenyang Wang, Hanbing Wang, Xi Chen, Yingying Liu, Lili Duan, Zhenshun Li, Liaoran Niu, Aqiang Fan, Siyu Wei, Han Bai, Yujie Zhang, Wei Zhou, Jinqiang Liu, Wanli Yang, Yu Han, Liu Hong, Daiming Fan   +16 more
wiley   +1 more source

A prospective study of risk factors and histopathological spectrum of patients with ovarian tumors admitted in a tertiary care hospital [PDF]

New Indian Journal of OBGYN
Objectives: This prospective study was conducted to evaluate risk factors and histopathological spectrum of patients with ovarian tumors. Methods: This study was conducted in NSCB Medical College, Jabalpur from February 2019 to July 2020 on 120 ...
Silika Madria, Vineeta Ghanghoriya, Prof. Kavita N Singh, Manisha Lokwani, Ranu Tiwari Mishra   +4 more
doaj   +1 more source

FOXA1 is a highly sensitive diagnostic marker for prostate cancer including small cell carcinoma of the prostate

Histopathology, Volume 89, Issue 2, Page 240-250, August 2026.
FOXA1 is a highly sensitive diagnostic marker for prostate cancer. Besides prostatic adenocarcinoma, it is also expressed in 57%–80% of metastatic or primary prostatic small cell carcinomas, which lose traditional prostatic markers including NKX3.1. Although it is less specific than NKX3.1, it can serve as a valuable adjunct for confirming prostatic ...
Jianping Zhao, Jun Yao, Hossein Hosseini, Ezra Baraban, Ruihe Lin, Charles C. Guo, Lei Huo, Wei Lu, Khaja Khan, Shufang Wang, Luisa Maren Solis Soto, Qingqing Ding   +11 more
wiley   +1 more source

Loss‐of‐Function Mutations in SWI/SNF Complexes Associated With Active Tumour Immune Microenvironment Clinical Response to Immune Checkpoint Blockade

Journal of Cellular and Molecular Medicine, Volume 30, Issue 16, August 2026.
ABSTRACT Chromatin remodelling SWI/SNF complexes are recurrently altered in malignancies, and some members were found to be associated with immune checkpoint blockade (ICB) response. However, it is unclear whether SWI/SNF complex genes as a collective factor have clinical relevance.
Zheng Yang, Zixuan Tian, Renji Liang, Yi Lu, Tengfei Zhu, Ya‐nan Wang, Wei Zhang   +6 more
wiley   +1 more source