Results 121 to 130 of about 87,203 (259)
Advanced Science, EarlyView.Ocular hypertension induces early hyperactivity in inner retinal inhibitory circuitry before substantial retinal ganglion cell loss. Sustained pharmacological inhibition of GABAergic/glycinergic neurotransmission and Vgat‐targeted Lin28 expression suppress this hyperactivity and improve RGC survival without reducing intraocular pressure. These findings
Eunji Hong +7 more
wiley +1 more source
Advanced Science, EarlyView.This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li +9 more
wiley +1 more source
Advanced Science, EarlyView.RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan +8 more
wiley +1 more source
Therapeutic Advances in UrologyWhat is this summary about? People with overactive bladder need to use the bathroom many times a day to urinate (pee). This need may often be sudden and may cause some people with overactive bladder to have accidental bladder leakage.
David Staskin +3 more
doaj +1 more source
Advanced Science, EarlyView.Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu +15 more
wiley +1 more source
Overactive bladder – definition, epidemiology, pathogenesis [PDF]
, 1970 The overactive bladder is characterized by the following symptoms: frequency, urgency, nocturia and urge incontinence, substantially affecting the quality of life of millions of people throughout the world, with recent findings estimating the prevalence ...
Wilk, Krzysztof +2 more
core
The Use of Botulinum Toxin A in Idiopathic Overactive Bladder Syndrome
, 2010 Overactive bladder syndrome continues to be a significant burden for the general population. Current first-line medical therapy often includes antimuscarinic medications designed for overactive bladder. Poor efficacy and significant side effects of these
Angelo Gousse +5 more
core +1 more source
Advanced Science, EarlyView.We demonstrate a stochastic spiking neural network by integrating an α‐ln2Se3/h‐BN/CIPS FeFET synapse with an Au/CIPS/Au neuron. Unlike conventional memoryless stochastic neurons, the proposed neuron generates stochastic spikes through the evolution of internal ferroelectric polarization states, giving rise to intrinsic temporal correlations and ...
Hanseo Jeon +7 more
wiley +1 more source
Thioredoxin‐2 Alleviates Osteoporosis by Restraining FOXO3a Nuclear Translocation
Advanced Science, EarlyView.Endothelial TRX2 preserves bone homeostasis by retaining FOXO3a at mitochondria and limiting TRAIL production. Loss of TRX2 or oxidative stress releases FOXO3a for nuclear translocation, increasing endothelial TRAIL secretion and driving osteoclast formation and bone loss.
Chi Zhan +10 more
wiley +1 more source
The changes of the Overactive Bladder Symptoms Scores after Botox injection with time.
, 2016 The changes of the Overactive Bladder Symptoms Scores after Botox injection with time.
Hann-Chorng Kuo (307485) +2 more
core +1 more source