Results 111 to 120 of about 87,203 (259)

Oxybutynin extended release for the management of overactive bladder: a clinical review

, 2009
AM Arisco, EK Brantly, SR KrausUniversity of Texas Health Science Center at San Antonio, Department of Urology, San Antonio, Texas, USAAbstract: Overactive bladder (OAB) is a common condition which negatively impacts the quality of life of afflicted ...
EK Brantly, SR Kraus, AM Arisco
core  

Depressed contractile responses to neurokinin A in idiopathic but not neurogenic overactive human detrusor muscle

, 2005
Objective The role of tachykinins such as neurokinin A in regulating bladder function is unclear, but NK2 receptors seem to mediate contraction in the human bladder and it has been suggested that these peptides may have a role in the pathophysiology of ...
Sellers, D. J., Hay, D. P. W., Chess-Williams, R., Chapple, C. R.   +3 more
core   +1 more source

SEC Mediates m6A Deposition and Transcription Pause Release to Drive Cell Identity Transition

Advanced Science, EarlyView.
The SEC promotes cell identity transitions by facilitating transcription pause release at key identity‐associated genes, including Klf4 and Myc during iPSC reprogramming and Nes and Tubb3 during ESC‐to‐neuroectodermal differentiation. During early iPSC reprogramming, this function additionally involves cooperation with METTL3‐associated m6A regulation.
Zhijing Zhang, Jingyi Xu, Yonghong Wu, Yitong Qu, Xinglin Hu, Yuchen Sun, Yanshuang Wu, Zhonghua Liu, Jiaqiang Wang, Lei Lei   +9 more
wiley   +1 more source

Prevalence and risk factors for overactive bladder symptoms in patients with artificial urinary sphincter

Scientific Reports
To demonstrate the prevalence and risk factors for overactive bladder symptoms associated with artificial urinary sphincter implantation, we investigated the patients who underwent primary artificial urinary sphincter implantation with severe urinary ...
Hisanori Taniguchi, Nae Takizawa, Hidefumi Kinoshita   +2 more
doaj   +1 more source

Atherogenic Index of Plasma mediates the association between Life’s Crucial 9 with overactive bladder: a secondary data analysis from NHANES

Frontiers in Endocrinology
BackgroundSome studies suggest a potential link between cardiovascular health, lipid, and overactive bladder (OAB). Life’s Crucial 9 (LC9) is a recently developed method for assessing cardiovascular health, while the Atherogenic Index of Plasma (AIP ...
Hongyang Gong, Hongyang Gong, Xiaomei Lin, Shaoqun Huang   +3 more
doaj   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Fesoterodine for the treatment of urinary incontinence and overactive bladder

, 2009
Pamela EllsworthThe Alpert School of Medicine at Brown University Providence, RI, USAAbstract: Overactive bladder (OAB) is a highly prevalent condition, affecting males and females. The prevalence increases with age. Behavioral therapy and antimuscarinic
Pamela Ellsworth
core  

Targeting Nupr1‐Mediated p53 Mitochondrial Sequestration Alleviates Aortic Dissection by Restoring the Gadd45b‐Dependent Survival Program

Advanced Science, EarlyView.
This study identifies Nupr1 as a crucial stress‐responsive orchestrator driving AD. Under severe stress, Nupr1 massively accumulates within mitochondria to sequester p53, triggering apoptosis and concurrently repressing the Gadd45b‐mediated survival program.
Xi Yang, Ke‐Yuan Chen, Yue Tian, Zong‐Sheng Jiang, Jian Lei, Xing‐Hui Zhuang, Jiang‐Bin Wu, Le‐Le Tang, Hao‐Yu Li, Xiao‐Hui Chen, Yue Wang, Yu‐Mei Li, Zhi‐Huang Qiu, Zi‐Wen Cai, Liang‐Wan Chen   +14 more
wiley   +1 more source

Oral Actinomyces Species Exposure is Associated with Anxiety‐Like Behavior, Mitochondrial Remodeling, and Altered GABAergic Pathways

Advanced Science, EarlyView.
Oral exposure to cannabis‐associated Actinomyces species, particularly A. meyeri, is associated with anxiety‐like behavior in mice in the absence of detectable bacterial translocation or overt systemic inflammation. These findings support a potential oral‐brain metabolic axis involving candidate metabolites such as arginine and argininosuccinate ...
Tabinda Salman, Zhenwu Luo, Douglas Johnson, Arshad A. Noorani, Zhuang Wan, Bogdan Bordieanu, Zhi‐wei Ye, Rachel D. Penrod, Hongxu Xian, Sylvia Fitting, Peter W. Kalivas, Wei Jiang   +11 more
wiley   +1 more source

Barriers to early and effective overactive bladder management in male patients with lower urinary tract symptoms.

PLoS ONE
Overactive bladder is underdiagnosed and undertreated in men as symptoms overlap with benign prostatic obstruction. This study identified barriers urologists encountered in effectively managing overactive bladder in men with lower urinary tract symptoms.
Paul Rasner, Maria Arcila-Ruiz, José Ailton Fernandes Silva, Umaphorn Nuanthaisong, Sung Yung Cho, Eric Chung   +5 more
doaj   +1 more source