Results 41 to 50 of about 6,718,193 (287)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Methodology and theory evaluation of overall equipment effectiveness based on market

open access: yes, 2010
Purpose - Continuous manufacturing systems used within the steel industry involve different machines and processes that are arranged in a sequence of operations in order to manufacture the products.
Anvari, Farhad   +6 more
core   +1 more source

Numerical Computation and Optimization of Turbine Blade Film Cooling

open access: yesAdvances in Mechanical Engineering, 2014
The effect of film cooling parameters on the cooling effectiveness of an actual turbine blade is studied numerically. Film cooling parameters such as the hole shape, holes distribution, blowing ratio, streamwise angle, and spanwise angle are investigated
Ahmed M. Elsayed   +2 more
doaj   +1 more source

The Effect of Using Ramps with Trench Cylindrical Holes on Film Cooling Effectiveness

open access: yesWasit Journal of Engineering Sciences, 2015
     The effect of introducing ramp with a cylindrical slot hole on the film cooling effectiveness has been investigated experimentally and numerically. The film cooling effectiveness measurements are obtained experimentally.
Ahmed A. Imram   +2 more
doaj   +1 more source

Experimental Study on the Improvement of Film Cooling Effectiveness of Various Modified Configurations Based on a Fan-Shaped Film Cooling Hole on an Endwall

open access: yesEnergies, 2023
Several studies have previously been conducted to improve the cooling performance of film cooling. However, most of the research has conducted experiments with film cooling holes on flat plates, and thus, the results of these studies do not encompass the
Seokmin Kim   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Use of in vitro human keratinocyte models to study the effect of cooling on chemotherapy drug-induced cytotoxicity [PDF]

open access: yes, 2014
A highly distressing side-effect of cancer chemotherapy is chemotherapy-induced alopecia (CIA). Scalp cooling remains the only treatment for CIA, yet there is no experimental evidence to support the cytoprotective capacity of cooling. We have established
van den Hurk, Corina J.   +6 more
core   +1 more source

Study of overall cooling effectiveness of discrete holes with different angles to concave wall

open access: yes, 2007
Overall cooling effectiveness of curved walls with discrete angled holes has been studied in the paper through approximate simulation employing experimental concave walls with a constant curvature, which were applied intensively in the curved duct for ...
Lin, Yu-zhen   +3 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Turbine cooling and heat transfer modelling for gas turbine performance simulation [PDF]

open access: yes, 2015
The successful design of cooling systems for gas turbine engines is a key factor to feasibility of new projects, as the trend for increasing turbine entry temperatures implies requirements for more sophisticated cooling methods.
Apostolidis, Asteris
core   +5 more sources

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