Results 51 to 60 of about 245,759 (304)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The Effect of Using Ramps with Trench Cylindrical Holes on Film Cooling Effectiveness
Wasit Journal of Engineering Sciences, 2015 The effect of introducing ramp with a cylindrical slot hole on the film cooling effectiveness has been investigated experimentally and numerically. The film cooling effectiveness measurements are obtained experimentally.
Ahmed A. Imram +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Numerical Computation and Optimization of Turbine Blade Film Cooling
Advances in Mechanical Engineering, 2014 The effect of film cooling parameters on the cooling effectiveness of an actual turbine blade is studied numerically. Film cooling parameters such as the hole shape, holes distribution, blowing ratio, streamwise angle, and spanwise angle are investigated
Ahmed M. Elsayed +2 more
doaj +1 more source
Numerical investigation of rectangular twisted hole on film cooling for gas turbine blades [PDF]
, 2014 This paper investigates a new method of film cooling using swirling coolant flow through a rectangular twisted film cooling holes with spirally corrugated tube. Two different air flows with different in temperatures were used in this study.
Fakhir, Ammar +3 more
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Experimental Study of Two Rows Hybrid Film Cooling Holes Over Flat Plate Surface Using IR Technology
Journal of Techniques, 2023 The study examines the effectiveness of two rows of hybrid film cooling holes over a plate surface using infrared technology and a thermal wind tunnel.
Ahmed A. Naji +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
International Journal of Aerospace Engineering, 2013 Film cooling is vital to gas turbine blades to protect them from high temperatures and hence high thermal stresses. In the current work, optimization of film cooling parameters on a flat plate is investigated numerically.
Ahmed M. Elsayed +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source