Results 71 to 80 of about 245,759 (304)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Experimental and Simulation Study on the Performance of Counter Flow Closed Cooling Tower Systems

International Journal of Technology, 2015
Cooling towers are required in building HVAC systems that use water as the cooling condenser fluid. Cooling towers used in this study are of the forced draft, counter flow, indirect/closed evaporative type.
Budihardjo, Nasruddin, Mohammad Hafil Nugraha   +2 more
doaj   +1 more source

Review of Waste Heat Utilisation from Data Centres [PDF]

, 2019
Rapidly increasing global internet traffic, mobile internet users and the number of Internet of Things (IoT) connections are driving exponential growth in demand for data centre and network services, which in turn is driving their electricity demand ...
Asthana, Abhishek, Sethuramalingam, Ramamoorthy, Weston, Peter   +2 more
core   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Performance Recovery of Natural Draft Dry Cooling Systems by Combined Air Leading Strategies

Energies, 2017
The cooling efficiency of natural draft dry cooling system (NDDCS) are vulnerable to ambient winds, so the implementation of measures against the wind effects is of great importance.
Weijia Wang, Lei Chen, Xianwei Huang, Lijun Yang, Xiaoze Du   +4 more
doaj   +1 more source

Comparison of Mixed H 2 H∞ with Regional Pole Placement Control and H 2 Optimal Control for the Design of Steam Condenser [PDF]

, 2020
This paper investigates the comparison between mixed H 2 /H∞ with regional pole placement control and H 2 optimal control for the design of steam condenser.
Jibril, Mustefa
core   +1 more source

Added Prognostic Value of EEG Reactivity in Comatose Patients Following Cardiac Arrest

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To evaluate the added prognostic value of EEG reactivity for favorable outcome compared with background analysis during and after targeted temperature management (TTM). Methods Prospective observational cohort study of comatose post–cardiac arrest patients admitted to a single academic center between 2017 and 2022, all undergoing ...
Sarah Caroyer, Marie Obrecht, Charlotte de Maeseneire, Charlotte Damien, Chantal Depondt, Lorenzo Ferlini, Estelle Rikir, Filippo Annoni, Fabio Silvio Taccone, Nicolas Mavroudakis, Benjamin Legros, Nicolas Gaspard   +11 more
wiley   +1 more source

Effectiveness of CFD simulation for the performance prediction of phase change building boards in the thermal environment control of indoor spaces [PDF]

, 2013
This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2013 ElsevierThis paper reports on a validation study of CFD models used to predict the effect of PCM clay boards on the ...
Alauzet, Arce, B.L. Gowreesunker, Bony, Chao, Chen, Feldman, Fisher, Gebremedhin, Gowreesunker, Hunt, Hussain, Hussain, International Energy Agency IEA, Medved, Mehling, Nagano, Rohdin, Rundle, S.A. Tassou, Shilei, Suarez, Susman, Tanasic, Veluri, Ye, Zalba, Zhai, Zhang, Zhang, Zhou   +30 more
core   +1 more source

Experimental Evaluation of 100Cr6 Steel Microindented Surfaces Under Lubricated Nonconformal Point Contacts

Advanced Engineering Materials, EarlyView.
The tribological behavior of 100Cr6 steel spheres textured via Vickers microindentation is evaluated under lubricated sliding by varying both dimple size and density. Fine and dense textures significantly reduce friction across all lubrication regimes, while large dimples increase it.
Farideh Davoodi, Pasquale Guglielmi, Gianfranco Palumbo, Giuseppe Carbone   +3 more
wiley   +1 more source

Potential of Utilizing Different Natural Cooling Sources to Reduce the Building Cooling Load and Cooling Energy Consumption: A Case Study in Urumqi

Energies, 2017
Generally, Central Asia is typical for regions with strong solar radiation and various natural cooling sources. The heat gain from the building envelope accounts for a large part of the cooling load there.
Chong Shen, Xianting Li
doaj   +1 more source