Results 121 to 130 of about 1,574,312 (309)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Segmentation of patients with small cell lung cancer into responders and non-responders using the optimal cross-validation technique

BMC Medical Research Methodology
Background The timing of treating cancer patients is an essential factor in the efficacy of treatment. So, patients who will not respond to current therapy should receive a different treatment as early as possible. Machine learning models can be built to
Elham Majd, Li Xing, Xuekui Zhang
doaj   +1 more source

Overall survival for sorafenib plus interleukin-2 compared with sorafenib alone in metastatic renal cell carcinoma (mRCC): final results of the ROSORC trial [PDF]

, 2013
Giuseppe Procopio, Elena Verzoni, Sergio Bracarda, Serafino Ricci, Cosimo Sacco, Laura Ridolfi, Camillo Porta, Rosalba Miceli, Nicoletta Zilembo, Emilio Bajetta   +9 more
openalex   +1 more source

The effect of maximum tumor diameter and 18F-FDG PET/CT imaging status on overall survival in Hodgkin lymphoma patients

, 2023
Vildan Gürsoy, Mehmet Refik Göktuğ, Fazıl Çağrı Hunutlu, İbrahim Ethem Pınar, Rıdvan Ali, Vildan Özkocaman, Fahir Özkalemkaş   +6 more
openalex   +2 more sources

NIMG-28. VALIDATION OF MODIFIED RESPONSE ASSESSMENT IN NEURO ONCOLOGY (mRANO) DETERMINED PFS AS A STRONG PREDICTOR OF OVERALL SURVIVAL IN RECURRENT GLIOBLASTOMA TREATED WITH A TARGETED IMMUNOTOXIN [PDF]

, 2020
Benjamin M. Ellingson, Chandtip Chandhasin, Melissa Coello, Nina Merchant, Fahar Merchant   +4 more
openalex   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Association of Wait Times to Surgical, Medical and Radiation Therapies with Overall Survival in Ontarians with Melanoma

, 2015
Alyson Crawford
openalex   +1 more source

Computed tomography radiomics signature via machine learning predicts RRM2 and overall survival in hepatocellular carcinoma [PDF]

, 2023
Qian Li, Xiawei Long, Yan Lin, Rong Liang, Yongqiang Li, Lianying Ge   +5 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source