Results 141 to 150 of about 1,574,312 (309)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Overall survival, conditioning, and MRD in MORPHO. [PDF]

Blood Adv
Gui G, Hourigan CS.
europepmc   +1 more source

Baseline geriatric 8 (G8) screening tool predicts overall survival in metastatic urothelial carcinoma treated with immune checkpoint inhibitors

Christopher H. Rhee, Subir Goyal, Y. Liu, Dylan J. Martini, Julie M. Shabto, Bassel Nazha, Omer Kucuk, Bradley Curtis Carthon, Mehmet Asim Bilen, Jacqueline T. Brown   +9 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Clinical Significance of MYBL2 Expression in Hepatocellular Carcinoma: Impact on Overall Survival. [PDF]

Onco Targets Ther
Chen CC, Wei CT, Hsuan CF, Yu TH, Hung WC, Wu CC, Lee TL, Tang WH, Chung FM, Lee YJ, Hsu CC.   +10 more
europepmc   +1 more source

Supplementary file 1_A nomogram for predicting overall survival in patients with muscle-invasive bladder cancer undergoing radical cystectomy: a retrospective cohort study.zip

Haiming Huang (803483), Han Hao (3152970), Jialin Du (455884), Lu Pang (848408), Qian Ma (69668), Haixia Li (271433), Lei Jin (120473)   +6 more
openalex   +1 more source

Comorbidity as a predictor of overall survival in prostate cancer patients treated with external beam radiotherapy combined with HDR brachytherapy boosts [PDF]

, 2016
Marie Hjälm-Eriksson, Anders Ullén, Hemming Johansson, Seymoure Levitt, Sten Nilsson, Karl‐Mikael Kälkner   +5 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Association of Neuronal Autoantibodies with Overall Survival in Patients with Gastric Cancer. [PDF]

Cancer Res Commun
Liu G, Tan X, Xu K, Liu J, Zheng Q, Huang X, Pan S, Li G, Hu Y, Liu H.   +9 more
europepmc   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source