Results 91 to 100 of about 4,032 (249)

Cyclic Mechanical Loading of Cardiomyocytes via Pressure‐Driven Non‐Planar Membrane Deformation in a Bioreactor System

Advanced Science, EarlyView.
In this research article, Mansoor and coworkers present a novel device that applies controlled mechanical stimuli to cardiomyocytes using pressure‐driven membrane deformation. By exposing cells to physiologically and pathologically relevant loading conditions, the platform reproduces distinct structural, functional and molecular responses associated ...
Haris Mansoor, Gabrielle Juul, Jil Patel, Heran Pradhan, Gram Hepner, Jackson Jewell, Mark Bardin, Ryan Slusser, Abigail Glezer, Leda Klouda, Melikhan Tanyeri, Anita Saraf   +11 more
wiley   +1 more source

Integrative solution of stress evolution in overburden roof strata during the coal seam mining by application of complex variable functions methodology

Rock Mechanics Bulletin
Large-scale roof collapse is a major dynamic hazard threatening the safe coal mine operations. Understanding the deformation and failure characteristics of overburden rock strata, as well as deciphering the stress evolution mechanism of overburden rock ...
Yinkai Li, Hongwei Wang, Zhanbin Zhu, Daixin Deng, Naisheng Jiang   +4 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Fracture structure of the overburden in the layered mining of extremely thick coal seams: Developmental patterns of caving zones and hydraulically conductive fracture zones and fracture characteristics

Meitian dizhi yu kantan
ObjectiveThe Zhunnan Coalfield, a coalfield on the southern margin of the Junggar Basin in Xinjiang, boasts abundant coal resources. However, water hazards in mines severely constrain the safe and efficient coal production in the coalfield.
Xin ZHANG, Youkuo CHEN, Hailun MENG, Qifa QIN, Xianggang CHENG, Rongjie HUANG, Hairui DONG, Wenbin SUN, Wei QIAO   +8 more
doaj   +1 more source

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

A Multimodal Magnetically Driven Soft Robot With Integrated Actuation‐Sensing Based on Photothermal Reprogramming Technology

Advanced Science, EarlyView.
This work reports a thermally safe, photothermally reprogrammable magnetic soft robot with its reprogramming temperature tuned to ∼39.5°C for biocompatibility. It achieves multimodal locomotion (max speed of 1.8 BL/s) and integrates liquid‐metal capacitive sensing to monitor self‐motion and detect environmental changes in simulated gastric environments,
Liu Yang, Yuliao Dong, Kangning Li, Cheng Jing, Ben Wang, Lin Xu   +5 more
wiley   +1 more source

Detection of Stratigraphic Structure and Surrounding Buried Faults in Complex Urban Areas: Case Study of East Lake High-tech Zone

CT Lilun yu yingyong yanjiu
Geological information such as stratigraphic structure characteristics, location of hidden faults, geometric characteristics, and overburden thickness in complex urban areas is extremely important for major engineering constructions such as light rail ...
Kun CHANG, Xiaohu DENG, Miao CHENG
doaj   +1 more source

Study on overburden rock structure characteristics and surrounding rock control technology of island working face

Scientific Reports
Based on the background of ZF2822 island working face in Xiagou Coal Mine, the characteristics of overburden fracture structure and surrounding rock control technology of island working face are explored by means of theoretical analysis, numerical simulation and field measurement.
Zhu Haoyu, Lai Xingping, Qiao Hao, Shan Pengfei, Wang Wenlin, Yang Wenhua, Wu Longquan, Jia Chong   +7 more
openaire   +3 more sources

CEBPG‐Mediated Palmitic Acid Adaptation of Cancer‐Associated Fibroblasts Drives Metastasis of Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study reveals a metabolic signaling axis in the OSCC microenvironment where palmitic acid (PA) drives the activation of CAFs. PA uptake triggers CEBPG‐dependent epigenetic remodeling to upregulate ERN1 and TMBIM6, thereby mitigating ER stress. This adaptive program sustains CAF survival and the pro‐metastatic phenotype, establishing this pathway ...
Yiling Duan, Yitong Li, Yufei Wu, Xiao Yang, Rui Li, Hui Zhao, Zhengjun Shang   +6 more
wiley   +1 more source

Synergistic Enhancement of Electrical‐Thermal Properties in KH550/G‐POSS Functionalized BN/Epoxy Composites for High‐Frequency Transformer Insulation

Advanced Science, EarlyView.
A BN@G‐POSS/EP nanocomposite is developed for high‐frequency transformer insulation in power electronic transformers. Through synergistic interface engineering, it simultaneously enhances thermal conductivity, reduces viscosity, and improves electro‐thermal stability.
Jun Jiang, Shaojie Luo, Dezhi Cui, Zeya Huang, Shuai Jiang, Renli Fu, Yuan Wang   +6 more
wiley   +1 more source