Results 101 to 110 of about 6,874,732 (236)

A Programmable Calcification Nanoplatform for Loco‐Regional Calcification‐Immune Hepatocellular Carcinoma Therapy

Advanced Science, EarlyView.
An in situ‐grown BP‐CaO2 nanoplatform supplies coordinated Ca2+, endogenous phosphate, and oxidative stress to convert tumor calcification from a passive endpoint into an active immune‐remodeling process. Widespread hydroxyapatite deposition is visualized by CT, while multi‐omics reveals MCOLN2 as a calcium‐responsive mediator linking biomineralization
Long Liu, Peng Li, Zhixiang Lu, Shuqin Xu, Juanjuan Wang, Kai Ma, Haodong Yu, Can Zhou, Hu Chen, Gang Liu, Yi Lyu, Shuang Bai   +11 more
wiley   +1 more source

Structure, coal thickness, and shallow overburden for the Carbon No. 6, Carbon No. 5 and Johnson coal beds in the Carbon mining district, Hanna coal field, southcentral Wyoming

, 1979
Structure, coal thickness, and shallow overburden for the Carbon No. 6, Carbon No.
G.B. Glass (10069864), J.T. Roberts (10069918)   +1 more
core   +1 more source

A Supramolecular Thermal Switch for Precision Pyroptosis via Host−Guest Recognition and Electrostatic Interactions

Advanced Science, EarlyView.
A supramolecular pyroptotic thermal switch encapsulates I3− within β‐cyclodextrin (β‐CD) and undergoes CaCO3 mineralization. Upon lysosomal acidification, CaCO3 is degraded, releasing Ca2+ and I3−. Concurrently, BODIPY activation converts I3− into I2, inducing oxidative stress and Ca2+ overload, which together trigger caspase‐3/GSDME‐mediated ...
Dan Wu, Jie Zhou, Yibin Cao, Kunmin Ping, Borui Zhao, Yanrong Yang, Chunyang Yu, Xinyang Yu, Shaolong Qi   +8 more
wiley   +1 more source

Structure, coal thickness, and shallow overburden for the Finch coal bed in the Carbon mining district, Hanna coal field southcentral Wyoming

, 1979
Structure, coal thickness, and shallow overburden for the Finch coal bed in the Carbon mining district, Hanna coal field southcentral ...
G.B. Glass (10069864), J.T. Roberts (10069918)   +1 more
core   +1 more source

Closing the Empirical Loop: Autonomous AI Agents Conduct End‐to‐end Research With Human Participants

Advanced Science, EarlyView.
A multi‐agent AI system autonomously executes the complete scientific workflow, from hypothesis to manuscript, across three psychological studies involving 288 participants. The system designs experiments, collects real world data, develops analysis pipelines, and writes manuscripts with theoretical rigor comparable to experienced researchers.
Gabrielle Wehr, Reuben Rideaux, Amaya J. Fox, David R. Lightfoot, Jason Tangen, Jason B. Mattingley, Shane E. Ehrhardt   +6 more
wiley   +1 more source

Bulldozer Pushes Overburden

, 1967
Overburden is stripped off asphalt deposits at the Asphalt Ridge Quarry by a ...

core  

Excavations conducted at the site of Campbellfield pottery Glasgow Ceramic Resource Disc 9 [PDF]

, 2006
The ceramic material listed, described, and photographed, on this ceramic resource disk is from an archaeological excavation carried out by AOC Archaeology Group for Coltart Early, on behalf of their client, on the site of the Campbellfield pottery in ...
Haggarty, George
core  

Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis‐Mediated Positive Feedback Loop

Advanced Science, EarlyView.
To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...
Wenjie Feng, Rui Yang, Chang Weng, Chen Li, Wanrui Shi, Yang Chen, Yang Yang, Yi Liu, Pengfei Ge, Hao Zhang   +9 more
wiley   +1 more source

Analysis of overburden structure and support working resistance of working face in fully-mechanized top coal caving with large mining height in ultra thick coal seam

矿业科学学报, 2017
In order to grasp the overburden structure and support working resistance of working face in fully-mechanized top coal caving with large mining height in ultra thick coal seam, this paper study the ultra thick coal seam in Tongxin coal mine.The fracture ...
Hou Yunbing, He Shangsen, Zhou Dianqi, Han Shuai, Zhou Yu   +4 more
doaj  

In Situ Profiling of Nanoscale Strains Uncovers Mechano‐Architectural Predictors of Aging and Osteoarthritis Emergence

Advanced Science, EarlyView.
In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Aikta Sharma, Lucinda A. E. Evans, Lucie E. Bourne, Jishizhan Chen, Alissa L. Parmenter, Joseph Brunet, Kamel Madi, Sebastian Marussi, Andrew A. Pitsillides, Peter D. Lee, Katherine A. Staines   +10 more
wiley   +1 more source