Results 101 to 110 of about 4,032 (249)

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source

Pemt Inhibition‐Mediated Vdac1 Oligomerization Regulates Mitochondrial Dysfunction, Apoptosis, and Inflammation in High‐Fat Diet‐Derived Liver Injury

Advanced Science, EarlyView.
ABSTRACT High‐fat diet (HFD)‐induced hepatic injury represents a pathology observed across vertebrates, yet the underlying mechanisms remain incompletely understood. Herein, the present study identifies phosphatidylethanolamine methyltransferase (Pemt), a key enzyme in phosphatidylcholine synthesis, as a critical regulator of mitochondrial homeostasis ...
Xianyong Bu, Xiufei Cao, Xin Yao, Baolin Li, Wencong Lai, Zengqi Zhao, Tingting Hao, Zhiwei Chen, Jianlong Du, Yueru Li, Kangsen Mai, Qinghui Ai   +11 more
wiley   +1 more source

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

Advanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu, Shiqing Chen, Ji Chen, Liuliu Ruan, Bowen Li, Weijian Chu, Shichen Huang, Dian Yu, Jing Tian, Yuhan Zhao, Yi Han, Xin Tang, Yong Ji   +12 more
wiley   +1 more source

Analysis of overburden structure and support working resistance of working face in fully-mechanized top coal caving with large mining height in ultra thick coal seam

矿业科学学报, 2017
In order to grasp the overburden structure and support working resistance of working face in fully-mechanized top coal caving with large mining height in ultra thick coal seam, this paper study the ultra thick coal seam in Tongxin coal mine.The fracture ...
Hou Yunbing, He Shangsen, Zhou Dianqi, Han Shuai, Zhou Yu   +4 more
doaj  

Unveiling a Hidden Conversion Pathway in CoSe2 Anodes via Rationally Designed CNT‐Interwoven Hollow Carbon Microclusters for High‐Performance Potassium‐Ion Batteries

Advanced Science, EarlyView.
A rational architectural design of hierarchical, CNT‐interwoven hollow carbon microclusters unlocks and stabilizes a unique monoclinic Co3Se4‐mediated conversion–insertion pathway for potassium storage. This structural confinement effectively guides the reaction kinetics and accommodates severe mechanical strain.
Ho Rim Kim, Seohyeon Jang, Hong Geun Oh, Jaewoo Lee, Jihun Yeom, Daiha Shin, Jiung Cho, Inho Nam, Seung‐Keun Park   +8 more
wiley   +1 more source

Fracturing behavior and fracture field evolution in overburden induced by mining of deeply buried extra-thick coal seam

Meitan xuebao
Revealing the disaster-inducing mechanisms of fracturing instability and the evolution patterns of fracture fields in the overburden during the mining of deeply buried extra-thick coal seams serves as the theoretical foundation for preventing hazards ...
Yi TAN, Shaopu ZHANG, Manchao HE, Hui LI, Wenbing GUO, Yu WANG, Erhu BAI, Chun ZHU, Jun YANG, Hao CHENG, Weiyu GUO, Ranlie WANG, Xinfa CAO, Linmao LI   +13 more
doaj   +1 more source

Structural Numerical Modelling Applied to the Capillary Barrier Effect Overburden of Acidic Tailings Ponds

Journal of Research in Science and Engineering
The issue of treating Acid Mine Drainage (AMD) has become a significant environmental concern for the global mining industry in recent years. AMD is generated by the leaching of sulfur-containing minerals (mainly pyrite, FeS2) in mine tailings, which react with atmospheric oxygen to form highly acidic solutions. These solutions contain heavy metal ions
Jianghong Du, QiuLing Xiong, Ailing Xun, Lu Zhang   +3 more
openaire   +1 more source

Engineered Au@CeO2 Hybrid Nanoparticles With Microenvironment Dependent Self‐Adjustability for Integration of Tumor‐Specific Photothermal‐Chemodynamic Therapy and Inflammation Prevention

Advanced Science, EarlyView.
An intelligent Au@CeO2 Hybrid Nanoparticles (ACEF) with microenvironment‐dependent self‐adjustability was engineered to not only perform efficient and tumor‐specific photothermal‐chemodynamic therapy for precise tumor elimination, but also serve as a ROS scavenger in healthy tissues around the tumor to avoid the unexpected oxidative damage and ...
Wenyun Mu, Wenjuan Tang, Handan Zhang, Jie Liu, Jiaqi Zhang, Yu Yao, Xiao Fu, Xin Chen, Yanmin Zhang   +8 more
wiley   +1 more source

A Metal‐Phenolic Nanocluster Orchestrates Mito‐Ca2+ Metabolic Autonomy for Tumor Ca2+ Interference Therapy

Advanced Science, EarlyView.
Tumor Ca2+ interference therapy suffers from self‐protective Ca2+ metabolic autoregulation. In this scenario, a versatile metal‐phenolic nanocluster (TCMH) is engineered to modulate mitochondrial calcium uniporter (MCU) ‐mediated mito‐Ca2+ metabolic autonomy.
Ronglong Chen, Jia Huang, Yuepeng Wang, Shucong Yao, Fei Wu, Juan Liu, Chunxue Song, Li Lin, Xijun Lin, Yingjie Deng, Chao Zhang, Zhiquan Huang, Zixian Huang, Lisi Xie   +13 more
wiley   +1 more source

Overburden breakage and surface damage evolution under high-intensity mining of shallow coal seams: evidence from Shendong mining area

Scientific Reports
During high-intensity mining of shallow coal seams, severe overburden movement and surface subsidence can lead to geological hazards like ground fissures.
Huan Zhang, Jie Zhang, Zhuhe Xu, Junwei Zhang, Shuangli Du, Shirong Wei, Xuejia Li   +6 more
doaj   +1 more source