Results 41 to 50 of about 18,948 (296)

Immunological Profiling suggests an Association between Treg dysfunction and Pain in Knee Osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Background Pain is the hallmark symptom of osteoarthritis (OA) and its biological drivers remain poorly understood. While the role of innate immunity in OA has been extensively studied, the involvement of adaptive immunity, in particular regulatory T cells (Tregs), is not well understood. Methods We performed omics profiling of peripheral blood from 46
Marie Binvignat, Johanna Dubois, Maria Marco Salvador, Paul Stys, Fabien Pitoiset, Alexandra Roux, Michèle Sastre, Signe Hassler, Roberta Lorenzon, Claire Ribet, Vanessa Mhanna, Hélène Vantomme, Leslie Adda, Pierre Barennes, Nicolas Coatnoan, Kenz Le Gouge, Caroline Aheng, Alice Courties, Lise Minssen, Atul J. Butte, Adrien Six, Michelle Rosenzwajg, Nicolas Tchitchek, Francis Berenbaum, David Klatzmann, Encarnita Mariotti‐Ferrandiz, Jérémie Sellam   +26 more
wiley   +1 more source

CONWAY-MAXWELL POISSON REGRESSION MODELING OF INFANT MORTALITY IN SOUTH SULAWESI

Media Statistika
Overdispersion is a common problem in count data that can lead to inaccurate parameter estimates in Poisson regression models. Quasi-Poisson and negative binomial regressions are often used to address overdispersion but have limitations, especially with ...
Oktaviana Oktaviana, Wahidah Sanusi, Aswi Aswi, Sukarna Sukarna, Serifat Adedamola Folorunso   +4 more
doaj   +1 more source

Longitudinal links of negative student–teacher relationships and positive class climate with traditional bullying and cyberbullying perpetration

British Educational Research Journal, EarlyView.
Abstract The current study aimed to investigate whether negative student–teacher relationships and within‐class perceptions of the class climate at the individual level, and positive class climates at the classroom level in fifth grade, were associated with traditional bullying and cyberbullying perpetration 1 year later, in sixth grade, in a sample of
Robert Thornberg, Björn Sjögren, Jun Sung Hong, Claudio Longobardi   +3 more
wiley   +1 more source

Recombining Knowledge for Climate Innovation: Evidence From US Energy Incumbents

Business Strategy and the Environment, EarlyView.
ABSTRACT As the climate crisis intensifies, energy incumbents must strategically transform their fossil‐fueled legacies to remain competitive and sustainable. Yet, little is known about how internal knowledge architectures and external industry positions jointly shape their capacity for climate innovation.
Kyung‐Baek Min, Kyzai Baikishieva, Young‐Choon Kim   +2 more
wiley   +1 more source

Digital Transformation for Eco‐Innovation: Evidence From Agriculture 4.0 Adoption in Wine Firms

Business Strategy and the Environment, EarlyView.
ABSTRACT Firms face a fundamental strategic dilemma: how to align digital transformation with environmental sustainability while maintaining competitive advantage. Drawing on the eco‐innovation and green business strategy literature, this paper investigates how Agriculture 4.0 technologies act as enablers of sustainability strategies.
Alessandro Muscio, Amir Maghssudipour, Yuntao Wang   +2 more
wiley   +1 more source

The Ridge-Hurdle Negative Binomial Regression Model: A Novel Solution for Zero-Inflated Counts in the Presence of Multicollinearity

Stats
Datasets with many zero outcomes are common in real-world studies and often exhibit overdispersion and strong correlations among predictors, creating challenges for standard count models.
HM Nayem, B. M. Golam Kibria
doaj   +1 more source

Temperature variability homogenized thermal responses in an ectotherm community along a European longitudinal gradient

Ecography, EarlyView.
Climate change, through rising temperatures, greater variability, and more frequent extremes, is reshaping insect phenology and thermal niches, with profound effects for pest outbreaks. Predicting these impacts requires a clear understanding of species and communities' responses across geographic gradients.
Ruining Li, Chun‐Sen Ma, Léna Jego, Cécile Le Lann, Joan Van Baaren, Gang Ma   +5 more
wiley   +1 more source

A Semiparametric Approach to Test for the Presence of INAR: Simulations and Empirical Applications

Mathematics, 2022
The present paper explores the application of bootstrap methods in testing for serial dependence in observed driven Integer-AutoRegressive (models) considering Poisson arrivals (P-INAR).
Lucio Palazzo, Riccardo Ievoli
doaj   +1 more source

The In Vitro Transgenic Rodent Assay in Primary MutaMouse Hepatocytes Compared to the Mammalian Cell Gene Mutation Assay Using the HPRT Gene

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT Gene mutations can be detected in mammalian cells in vitro using indicator genes such as the hypoxanthine‐guanine‐phosphoribosyltransferase (HPRT) gene. These assays have been adopted as OECD test guidelines (TG, e.g., OECD TG no. 476) and are used for regulatory purposes.
Alina Göpfert, Kylee Kendra Marie Ronnenberg, Claudia Ruelker, Silke Spang, Naveed Honarvar, Robert Landsiedel   +5 more
wiley   +1 more source

L‐Relationship between uncertainty and average seizure frequency in clinical trials of antiseizure medications

Epilepsia, EarlyView.
Abstract Objective Antiseizure medications are approved based on clinical trials that demonstrate their efficacy as measured by reductions in seizure frequency (SF). When designing these trials, trialists must select inclusion criteria where SF can be reliably measured to maintain statistical power.
Wesley T. Kerr, Neo Kok, Katherine N. McFarlane, Advith S. Reddy, Lavanya Biju, Jacqueline A. French, Daniel M. Goldenholz   +6 more
wiley   +1 more source