Results 101 to 110 of about 1,514,926 (296)
British Journal of Clinical Pharmacology, EarlyView.ABSTRACT Aims Imatinib improves hemodynamics in pulmonary arterial hypertension (PAH), but dose‐dependent toxicity has limited its clinical development. We aimed to quantify the dose–efficacy–toxicity relationship and evaluate alternative dosing strategies using data from the PIPAH trial.
Medhat M. Said +13 more
wiley +1 more source
Drug Overdose Surveillance and Epidemiology (DOSE) System are Used for Action [PDF]
The overdose epidemic affects people in every age group, sex category, race and ethnicity, and geographic area. Monitoring trends in emergency department (ED) visits and hospitalizations for overdose can provide timely data to inform drug overdose ...
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Acute toxic leucoencephalopathy following protonitazene ingestion
British Journal of Clinical Pharmacology, EarlyView.Background Distribution of illicit counterfeit alprazolam containing the highly potent synthetic opioid‐receptor agonist protonitazene recently resulted in a number of severe overdoses in Ireland. We report three cases that presented to our hospital, within 6 weeks of one another, following ingestion of illicitly‐sourced alprazolam.
Ruadhan O'Laoi +5 more
wiley +1 more source
APHL Polysubstance Overdose Expanded Biosurveillance Strategy [PDF]
Running title: APHL Polysubstance Overdose Expanded Biosurveillance Strategy.This project was 100% funded with federal funds from a federal program of $291,833.
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Copula‐based joint modelling of emergency department visits with time‐varying dependence
Canadian Journal of Statistics, EarlyView.Abstract Jointly modelling multiple correlated count time series is essential in health services research, where outcomes like emergency visits for mental health and substance use often evolve together. Ignoring these dependencies can obscure meaningful trends and limit the effectiveness of policy evaluation.
Guanjie Lyu, Cindy Feng, Lihui Liu
wiley +1 more source
Investigating the Cytoskeleton of DRGs Using Cryo‐Electron Microscopy and Deep Learning
Cytoskeleton, EarlyView.ABSTRACT We describe a method for determining the ultrastructural organization of axons and varicosities of cultured dorsal root ganglion (DRG) neurons using cryogenic electron microscopy (cryo‐EM). Cryo‐EM reveals the dimensions, proximity, and overall organization of biological specimens in a near‐native state, avoiding artifacts of fixation and ...
M. Neal Waxham +3 more
wiley +1 more source
Drug and Alcohol Dependence ReportsBackground: The fourth wave of the overdose epidemic in the United States (US) is characterized by deaths involving fentanyl with stimulants. Understanding patterns of substance use as novel drugs continue to emerge is critical to inform overdose ...
Jacqueline E. Rudolph +8 more
doaj +1 more source
Increases in fentanyl drug confiscations and fentanyl-related overdose fatalities [PDF]
October 26, 2015, 0815 EDT (08:15 AM EDT)CDCHAN-00384The Centers for Disease Control and Prevention (CDC) and the Drug Enforcement Administration (DEA) are investigating recent increases in fentanyl-related unintentional overdose fatalities in multiple ...
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Cytoskeleton, EarlyView.ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith +9 more
wiley +1 more source
Assessing knowledge, attitudes, and barriers to opioid overdose among college students
BMC Public HealthBackground College students are a key population for opioid use, misuse, and subsequent exposure to overdose events. However, their knowledge and attitudes in response to opioid overdose warrant further study. To assess this gap, we surveyed graduate and
Abass Babatunde +4 more
doaj +1 more source