Results 161 to 170 of about 1,171,772 (218)

POLQ Overexpression Is Associated with an Increased Somatic Mutation Load and PLK4 Overexpression in Lung Adenocarcinoma

Cancers, 2019
DNA Polymerase Theta (POLQ) is a DNA polymerase involved in error-prone translesion DNA synthesis (TLS) and error-prone repair of DNA double-strand breaks (DSBs).
Kazuo Tsuchiya, Kazuhito Fúnaì, Katsuhiro Yoshimura   +2 more
exaly   +2 more sources

FOXG1 is overexpressed in hepatoblastoma

Human Pathology, 2007
Bacterial artificial chromosome array comparative genomic hybridization analysis of hepatoblastomas reveals a deletion in the 14q12 locus in 12 of 16 cases. A high frequency of copy gain is seen on chromosomes 1q, 2, 5p, 8, and 20. Frequent deletions are also seen at 6q, 17q, and 1p with less frequent gains on 4p, 6p, and 19p.
Adekunle Michael, Adesina, Yummy, Nguyen, Preethi, Guanaratne, Joseph, Pulliam, Dolores, Lopez-Terrada, Judy, Margolin, Milton, Finegold   +6 more
openaire   +2 more sources

The transience of transient overexpression

Nature Methods, 2013
Much of what is known about mammalian cell regulation has been achieved with the aid of transiently transfected cells. However, overexpression can violate balanced gene dosage, affecting protein folding, complex assembly and downstream regulation. To avoid these problems, genome engineering technologies now enable the generation of stable cell lines ...
Gibson, Toby J, Seiler, Markus, Veitia, Reiner A   +2 more
openaire   +3 more sources

Cad Overexpression in Mammalian Cells

Clinical Biochemistry, 1997
Hamster CAD is a multifunctional protein which catalyzes the first three enzymatic steps of de novo pyrimidine biosynthesis.1'2 The major catalytic domains of CAD are car-bamyl phosphate synthetase (CPSase) (EC 6.3.5.5), dihydroorotase (DHOase) (EC 3.5.2.3), and aspartate transcarbamylase (ATCase) (EC 2.1.3.2). The first enzyme of the pathway, carbamyl
Y, Qiu, J N, Davidson
openaire   +2 more sources

Lentiviral Overexpression of miRNAs

2013
Deregulation of microRNAs (miRNAs) has been attributed to almost any human disease analyzed to date. This calls for models and experimental strategies for functional analyses of miRNAs enabling miRNA overexpression or suppression in target cell and/or tissues.
Hannah, Zöllner, Stephan A, Hahn, Abdelouahid, Maghnouj   +2 more
openaire   +2 more sources

SFRP4 was overexpressed in colorectal carcinoma

Journal of Cancer Research and Clinical Oncology, 2009
Secreted frizzled related proteins (SFRPs) play important roles in tumor progress through antagonizing Wnt signaling. However, SFRPs has not been systematically studied in colorectal tumors. The primary purpose of the study was to discuss the relationship between the expression of SFRPs and the clinicopathologic features of colorectal cancer (CRC).The ...
Dan, Huang, Bin, Yu, Yun, Deng, Weiqi, Sheng, Zhilei, Peng, Wenxin, Qin, Xiang, Du   +6 more
openaire   +2 more sources