Results 181 to 190 of about 1,435,507 (315)

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Overexpression of the Large-Conductance Mechanosensitive Channel Gene in <i>Oenococcus oeni</i> Enhances Its Ethanol Stress Tolerance. [PDF]

Microorganisms
Liu L, Zhao Y, Zhang L, Zheng Y, Peng S, Zhao H, Zhao X, Zhang Y, Fang J, Song W.   +9 more
europepmc   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

Overexpression of HLJ1 in lung adenocarcinoma cells lead to suppression of tumor growth and cell invasive competence

, 2014
Chi-Chung Wang, Jeremy J. W. Chen, Meng-Feng Tsai, Chun-Yi Wu, Chiung-Yao Juan, Pan-Chyr Yang, Hsang-Yu Chen   +6 more
core  

RBM15/IGF2BP2-PTPRH m6A regulatory axis in non-small cell lung cancer. [PDF]

Cell Oncol (Dordr)
Qiu K, Zheng X, Li H, Zhang J, Xie Z, Chen H, Hu Z, Sun Y, Chen Z, Tong J, Mu Y, Yao Y, Chen W, Xu G.   +13 more
europepmc   +1 more source

A Mouse Model for the Overexpression of Methyltransferases

, 2010
One of the epigenetic mechanisms by which gene expression is regulated is the methylation of DNA. Erroneous DNA methylation can cause a vast spectrum of diseases. A mouse model was created in this study to investigate whether the overexpression of the somatic form of Dnmt1, Dnmt1s, is sufficient to cause erroneous methylation and disease.
openaire   +2 more sources

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Overexpression of SLC44A4 suppresses ferroptosis and reduces lipid peroxidation <i>via</i> noncanonical NF-κB signaling in a NIK-dependent manner. [PDF]

Ann Med
Li T, Xu Y, Song W, Chang H, He J, Liu S, Liu Z, Xu Y, Yao Q, Song K.   +9 more
europepmc   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

EZH2 Regulates the Pluripotency of Mouse Embryonic Stem Cells by Modulating <i>Nanog</i> Expression Under PKC Inhibition. [PDF]

Biology (Basel)
Wu F, Liu Z, Gao Y, Li J, Chen X, Wang X, Liu L, Du F.   +7 more
europepmc   +1 more source