Results 171 to 180 of about 1,171,772 (218)
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LRP overexpression in monocytic lineage
Leukemia Research, 2003The failure to chemotherapy is a multi factorial phenomenon and lung resistance protein (LRP) overexpression has already been discussed as implicated in drug resistance. But its role is still discussed. In 1996, we studied the expression of LRP and P170 (MDR) in a series of leukemias, at the time of diagnosis, by immunocytochemical (ICC) method.
Béatrice Ly, Sunnaram +6 more
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The consequence of PRELP overexpression on skin
Matrix Biology, 2007PRELP is a member of the small leucine-rich repeat proteoglycan family that is abundantly expressed in many cartilages compared to other connective tissues. To study the consequence of PRELP overexpression in tissues where it is normally expressed at low abundance, transgenic mice were generated in which the human PRELP transgene was placed under ...
J, Grover +4 more
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Overexpression of osteopontin in hepatocellular carcinoma
Pathology International, 2002Human hepatocellular carcinoma (HCC) is one of the most common and aggressive malignancies. In order to identify genes involved in HCC progression, we conducted a differential display analysis and found osteopontin (OPN) to be overexpressed in HCC. OPN is known to be a secreted adhesive glycoprotein, associated with tumorigenesis and metastasis in ...
Masahiro, Gotoh +4 more
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Overexpressing the most abundant enzyme
Nature Plants, 2018Plants’ photosynthetic capacity at high light is limited by the kinetics of the slow, carbon-dioxide-fixing enzyme Rubisco. Increasing Rubisco content in a C4 crop plant is now shown to enhance photosynthesis and growth.
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HER2 overexpression and cancer targeting
Seminars in Oncology, 2001Overexpression of the HER2/neu oncogene is a frequent molecular event in multiple human cancers including breast and ovarian cancer. Patients with breast cancer that overexpress HER2/neu have a poor prognosis, shorter relapse time, and low survival rate.
S C, Wang, M C, Hung
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Rationalizing membrane protein overexpression
Trends in Biotechnology, 2006Functional and structural studies of membrane proteins usually require overexpression of the proteins in question. Often, however, the 'trial and error' approaches that are mainly used to produce membrane proteins are not successful. Our rapidly increasing understanding of membrane protein insertion, folding and degradation means that membrane protein ...
Samuel, Wagner +3 more
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Nucleophosmin is overexpressed in thyroid tumors
Biochemical and Biophysical Research Communications, 2010Nucleophosmin (NPM) is a protein that contributes to several cell functions. Depending on the context, it can act as an oncogene or tumor suppressor. No data are available on NPM expression in thyroid cells. In this work, we analyzed both NPM mRNA and protein levels in a series of human thyroid tumor tissues and cell lines.
PIANTA, Annalisa +12 more
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N-MYC overexpression and neuroblastomas
Trends in Pharmacological Sciences, 2002In the advanced stages of human neuroblastomas, amplification of the N-MYC oncogene is a frequent event and correlates with poor prognosis and enhanced neovascularization. N-MYC amplification results in high N-MYC protein levels that can perturb the finely tuned interplay of N-MYC and MAX and could eventually induce abnormal expression patterns of ...
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CENP-A overexpression promotes aneuploidy with karyotypic heterogeneity
Journal of Cell Biology, 2021Roshan Shrestha +2 more
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