Results 31 to 40 of about 2,719,020 (292)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Sangiran For The Archaeologist A Short Guide For Students
Berkala Arkeologi, 1989 To-day the most important locality of Pleistocene hominids in Southeast Asia is Sangiran. This is where Homo erectus fossils come from, to which species the famous Pithecanthropus and Meganthropus belong.
Gert-Jan Bartstra
doaj +1 more source
An overview and synthesis of research on English loanwords in Japanese
Vocabulary Learning and Instruction, 2020 Loanwords in Japanese that share form and meaning with English words are referred to as Japanese-English cognates (e.g., ラジオ /radӡio/ “radio”) and are of fundamental concern for researchers concerned with vocabulary learning and instruction.
David Allen
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Algebra and Math Modeling: an overview of brazilian research in the last years
Educação Matemática Debate, 2019 In this article, a overview of studies involving Mathematical Modeling and Algebra, focused on Basic Education, is presented with the objective of analyzing how the researches use Mathematical Modeling to aid in Algebra classes.
Camilla do Valle Soares Cedraz +3 more
doaj +1 more source
Вопросы вирусологии, 2018 Modern chemotherapy of cytomegalovirus (CMV) infections has a very limited arsenal of first-line drugs. These are preparations of ganciclovir (GCV) belonging to the class of modified nucleosides and its metabolic precursor ganciclovir valine ester. After
V. L. Andronova
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source