Results 41 to 50 of about 6,564,944 (299)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

An overview and synthesis of research on English loanwords in Japanese

open access: yesVocabulary Learning and Instruction, 2020
Loanwords in Japanese that share form and meaning with English words are referred to as Japanese-English cognates (e.g., ラジオ /radӡio/ “radio”) and are of fundamental concern for researchers concerned with vocabulary learning and instruction.
David Allen
doaj   +1 more source

Combustion overview [PDF]

open access: yes, 1984
The objective of this effort is to develop improved analytical models of the internal combustor flow field and liner heat transfer as a means to shorten combustor development time and increase turbine engine hot section life.
Schultz, D. F.
core   +1 more source

Smashed hits: Overview [PDF]

open access: yes, 1998
Though its trials are less monitored and recorded, music is no less subject to censorship than other forms of artistic expression, and the methods are much the same.
Petley, J
core   +1 more source

Algebra and Math Modeling: an overview of brazilian research in the last years

open access: yesEducação Matemática Debate, 2019
In this article, a overview of studies involving Mathematical Modeling and Algebra, focused on Basic Education, is presented with the objective of analyzing how the researches use Mathematical Modeling to aid in Algebra classes.
Camilla do Valle Soares Cedraz   +3 more
doaj   +1 more source

MODERN ETHIOTROPIC CHEMOTHERAPY OF HUMAN CYTOMEGALOVIRUS INFECTION: CLINICAL EFFECTIVENESS, MOLECULAR MECHANISM OF ACTION, DRUG RESISTANCE, NEW TRENDS AND PROSPECTS. PART 1

open access: yesВопросы вирусологии, 2018
Modern chemotherapy of cytomegalovirus (CMV) infections has a very limited arsenal of first-line drugs. These are preparations of ganciclovir (GCV) belonging to the class of modified nucleosides and its metabolic precursor ganciclovir valine ester. After
V. L. Andronova
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Table of Contents

open access: yesAethiopica, 2019
Table of ...
Editorial Team
doaj   +1 more source

Current development and technology status of high performance rudders

open access: yesZhongguo Jianchuan Yanjiu, 2020
The rudder performance is closely related to the ship performance,and the application of high performance rudders has important significance on improving maneuverability and rapidity of the ship.
LI Feng   +3 more
doaj   +1 more source

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