Results 41 to 50 of about 2,794,885 (285)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

open access: yesFEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Sangiran For The Archaeologist A Short Guide For Students

open access: yesBerkala Arkeologi, 1989
To-day the most important locality of Pleistocene hominids in Southeast Asia is Sangiran. This is where Homo erectus fossils come from, to which species the famous Pithecanthropus and Meganthropus belong.
Gert-Jan Bartstra
doaj   +1 more source

An overview and synthesis of research on English loanwords in Japanese

open access: yesVocabulary Learning and Instruction, 2020
Loanwords in Japanese that share form and meaning with English words are referred to as Japanese-English cognates (e.g., ラジオ /radӡio/ “radio”) and are of fundamental concern for researchers concerned with vocabulary learning and instruction.
David Allen
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Algebra and Math Modeling: an overview of brazilian research in the last years

open access: yesEducação Matemática Debate, 2019
In this article, a overview of studies involving Mathematical Modeling and Algebra, focused on Basic Education, is presented with the objective of analyzing how the researches use Mathematical Modeling to aid in Algebra classes.
Camilla do Valle Soares Cedraz   +3 more
doaj   +1 more source

MODERN ETHIOTROPIC CHEMOTHERAPY OF HUMAN CYTOMEGALOVIRUS INFECTION: CLINICAL EFFECTIVENESS, MOLECULAR MECHANISM OF ACTION, DRUG RESISTANCE, NEW TRENDS AND PROSPECTS. PART 1

open access: yesВопросы вирусологии, 2018
Modern chemotherapy of cytomegalovirus (CMV) infections has a very limited arsenal of first-line drugs. These are preparations of ganciclovir (GCV) belonging to the class of modified nucleosides and its metabolic precursor ganciclovir valine ester. After
V. L. Andronova
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Co-citation Analysis: An Overview [PDF]

open access: yes, 2011
This article gives an overview of co-citation analysis and its applications in tracking the linkages among the intellectual works and mapping the evolutionary structure of scientific disciplines.
Bhanumurthy, K.   +3 more
core   +1 more source

Table of Contents

open access: yesAethiopica, 2019
Table of ...
Editorial Team
doaj   +1 more source

Current development and technology status of high performance rudders

open access: yesZhongguo Jianchuan Yanjiu, 2020
The rudder performance is closely related to the ship performance,and the application of high performance rudders has important significance on improving maneuverability and rapidity of the ship.
LI Feng   +3 more
doaj   +1 more source

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