Results 61 to 70 of about 6,564,944 (299)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
An overview of New England's economic performance in 2007 [PDF]
New England’s economy showed bright signs of growth in 2007, but residential real estate cast a shadow. Job growth was moderate and on par with that of the nation, but the region fared better with an unemployment rate lower than the national average ...
Charu Nidhi Gupta +3 more
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Growing... but slowing? : an overview of New England's economic performance in 2006 [PDF]
New England’s economic performance was somewhat mixed during 2006. On one hand, all six states added jobs over the course of the year, and the region’s unemployment rate remained steady. The region as a whole picked up jobs in nearly all major industries.
Erin Langlois +5 more
core
, 2003 The status of stochastic cooling and developments over the years are reviewed with reference to much of the original work. Both theoretical and technological subjects are considered.Comment: 10 pages.
Barry +29 more
core +2 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
8-Shaped Inductors: An Essential Addition to RFIC Designers’ Toolbox
IEEE Open Journal of the Solid-State Circuits SocietyThe rapidly advancing field of millimeter-wave (mm-wave) radio-frequency integrated circuit (RFIC) design has ushered in an era of remarkable innovation, particularly in the realm of on-chip passive devices. Among them, 8-shaped inductors have emerged as
Pingda Guan +6 more
doaj +1 more source
Societal assessment overview [PDF]
, 1980 The decision to proceed with SPS depends on a political determination that commitment of the economic, institutional, and social energies required for its implementation is a worthwhile investment.
Bloomquist, C. E.
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source