Results 81 to 90 of about 1,483,118 (292)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Repetitive transcranial magnetic stimulation for Alzheimer’s disease: an overview of systematic reviews and meta-analysis

Frontiers in Aging Neuroscience
ObjectiveAlzheimer’s disease (AD) is a prevalent neurodegenerative condition that significantly impacts both individuals and society. This study aims to evaluate the effectiveness of repetitive transcranial magnetic stimulation (rTMS) as a treatment for ...
Hua Xue, Ya-xin Li, Ya-song Xiao, Wen-hui Fan, Hong-xian He   +4 more
doaj   +1 more source

Current State of Dynamic Vehicle Routing Problems Solved by Ant Colony Optimization Algorithm

Tehnički Glasnik, 2021
Dynamic Vehicle Routing Problem is a more complex version of Vehicle Routing Problem, closer to the present, real-world problems. Heuristic methods are used to solve the problem as Vehicle Routing Problem is NP-hard. Among many different solution methods,
Luka Olivari, Goran Đukić
doaj  

Pediatric emergency medical services and their drawbacks

Journal of Emergencies, Trauma and Shock, 2012
Aim: To survey the literature on Pediatric Emergency Medical Services (PEMS) with an aim to focus its drawbacks and emphasize the means of improvement.
Abdullah Foraih Al-Anazi
doaj   +1 more source

Weighing the Giants – I. Weak-lensing masses for 51 massive galaxy clusters: project overview, data analysis methods and cluster images [PDF]

, 2014
Anja von der Linden, Mark T. Allen, Douglas Applegate, Patrick L. Kelly, S. W. Allen, H. Ebeling, P. R. Burchat, D. L. Burke, D. Donovan, R. Glenn Morris, R. D. Blandford, T. Erben, A. Mantz   +12 more
openalex   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Overview of recent results from the ST40 compact high-field spherical tokamak

Nuclear Fusion
ST40 is a compact, high-field ( $B_{\mathrm{T0}}\unicode{x2A7D} 2.1\,\,\,\textrm{T}$ ) spherical tokamak (ST) with a mission to expand the physics and technology basis for the ST route to commercial fusion.
S.A.M. McNamara, A. Alieva, M.S. Anastopoulos Tzanis, O. Asunta, J. Bland, H. Bohlin, P.F. Buxton, C. Colgan, A. Dnestrovskii, E. du Toit, M. Fontana, M. Gemmell, M.P. Gryaznevich, J. Hakosalo, M.R. Hardman, D. Harryman, D. Hoffman, M. Iliasova, S. Janhunen, F. Janky, J.B. Lister, H.F. Lowe, E. Maartensson, C. Marsden, S.Y. Medvedev, S.R. Mirfayzi, M. Moscheni, G. Naylor, V. Nemytov, J. Njau, T. O’Gorman, D. Osin, T. Pyragius, A. Rengle, M. Romanelli, C. Romero, M. Sertoli, V. Shevchenko, J. Sinha, A. Sladkomedova, S. Sridhar, J. Stirling, Y. Takase, P.R. Thomas, J. Varje, E. Vekshina, B. Vincent, H.V. Willett, J. Wood, E. Wooldridge, D. Zakhar, X. Zhang, D. Battaglia, N. Bertelli, P.J. Bonofiglo, L.F. Delgado-Aparicio, V.N. Duarte, N.N. Gorelenkov, M. de Haas, S.M. Kaye, R. Maingi, D. Mueller, M. Ono, M. Podesta, Y. Ren, S. Trieu, E. Delabie, T.K. Gray, B. Lomanowski, E.A. Unterberg, O. Marchuk, the ST40 Team   +71 more
doaj   +1 more source

Lifestyle intervention Tai Chi for adult patients with type 2 diabetes mellitus: a PRIO-harms based overview of 17 systematic reviews

Frontiers in Endocrinology
ObjectiveTo systematically summarize current evidence and determine the clinical effectiveness and safety of Tai Chi for type 2 diabetes mellitus (T2DM) in adults by conducting an overview of systematic reviews (SRs).MethodsA systematic search ...
Furong Zhang, Xixi Chen, Xicen Liu, Xiaoyu Shen, Tianyu Liu, Fang Zeng, Rongjiang Jin   +6 more
doaj   +1 more source

Aspirin for prophylactic use in the primary prevention of cardiovascular disease and cancer: a systematic review and overview of reviews

Health Technology Assessment, 2013
Background: Prophylactic aspirin has been considered to be beneficial in reducing the risks of heart disease and cancer. However, potential benefits must be balanced against the possible harm from side effects, such as bleeding and gastrointestinal (GI ...
P Sutcliffe, M Connock, T Gurung, K Freeman, S Johnson, N-B Kandala, A Grove, B Gurung, S Morrow, A Clarke   +9 more
doaj   +1 more source

Dynamical dark matter. I. Theoretical overview [PDF]

, 2012
Keith R. Dienes, Brooks Thomas
openalex   +1 more source