Results 51 to 60 of about 270,389 (267)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Promoting well-being at school, university, and workplaces: an overview of reviews of interventions to enhance well-being in three contexts

Frontiers in Education
This overview of reviews aimed to identify and describe existing learning paths and interventions to improve well-being and its dimensions in three contexts: secondary school, university, and workplaces. We searched four databases (APA PsycInfo, Proquest,
Lucrezia Perrella, Rita Zarbo, Stefania Lucia Buccheri, Stefania Cuccu, Daniela Fadda, Ernesto Lodi, Patrizia Patrizi, Maria Guarnera, Paola Magnano, Maria Luisa Pedditzi, L. Francesca Scalas   +10 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Physical activity interventions for older adults – an overview of systematic reviews

BMC Public Health
Background The proportion of people meeting recommended physical activity (PA) guidelines declines with age. Older adults who are physically inactive have an increased risk of: all-cause mortality; chronic diseases; injury and reduced cognitive ...
Jo Canneaux, Richard A. Sharpe, Noreen Orr, Jane R. Smith, Alison Bethel, Cassandra Phoenix, Victoria A. Goodwin, Iain Lang, Ruth Garside   +8 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The overview reporting map: a visual tool for overviews of systematic reviews

Journal of Clinical Epidemiology
This study aims to present the Overview Reporting Map (ORMap), a structured approach for summarizing and visually representing results from overviews of Cochrane Systematic Reviews (CSRs). The goal is to address the difficulty in effectively reporting information from overviews of reviews.ORMap was developed progressively and applied through two ...
Negrini, Stefano, Arienti, Chiara, Cordani, Claudio, Kiekens, Carlotte   +3 more
openaire   +3 more sources

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

The Systematic Review

AJN, American Journal of Nursing, 2014
This article is the first in a new series on systematic reviews from the Joanna Briggs Institute, an international collaborative supporting evidence-based practice in nursing, medicine, and allied health fields. The purpose of the series is to show nurses how to conduct a systematic review-one step at a time.
Edoardo, Aromataris, Alan, Pearson
openaire   +3 more sources

Review of AdS/CFT Integrability: An Overview [PDF]

Letters in Mathematical Physics, 2011
This is the introductory chapter of a review collection on integrability in the context of the AdS/CFT correspondence. In the collection we present an overview of the achievements and the status of this subject as of the year 2010.
Beisert, N, Ahn, C, Alday, LF, Bajnok, Z, Drummond, JM, Freyhult, L, Gromov, N, Janik, RA, Kazakov, V, Klose, T, Korchemsky, GP, Kristjansen, C, Magro, M, McLoughlin, T, Minahan, JA, Nepomechie, RI, Rej, A, Roiban, R, Schafer-Nameki, S, Sieg, C, Staudacher, M, Torrielli, A, Tseytlin, AA, Vieira, P, Volin, D, Zoubos, K   +25 more
openaire   +8 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source