Results 61 to 70 of about 250,561 (268)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

A decision tool to help researchers make decisions about including systematic reviews in overviews of reviews of healthcare interventions

Systematic Reviews, 2019
Background Overviews of reviews of healthcare interventions (overviews) integrate information from multiple systematic reviews (SRs) to provide a single synthesis of relevant evidence for decision-making.
Michelle Pollock, Ricardo M. Fernandes, Amanda S. Newton, Shannon D. Scott, Lisa Hartling   +4 more
doaj   +1 more source

Evaluation of surgical and nonsurgical interventions for clavicle fractures

Acta Orthopaedica et Traumatologica Turcica, 2020
Objective:The aim of this study was to review all systematic reviews and meta-analyses and provide an overview of the evidence of efficacy of interventions for clavicle fractures.
Shengping Yang, Rui Zhang, Qingling Zhu, Guan Wang, Xuanxi Ding, Jianmin Wang   +5 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The safety and effectiveness of music medicine as an intervention for depression: A systematic evaluation and re‐evaluation

Brain and Behavior
Background As the methodological quality and evidence level of the existing systematic reviews (SRs) on music as an intervention for depression have not been thoroughly evaluated, a systematic evaluation and re‐evaluation (SERE) was conducted.
Dayuan Zhong, Hui Cheng, Zhenghua Pan, Yumei Liu, Pingwen Liu, Jiarong Li, Jiaqi Chen, Yihui Deng, Xueming Ou, Huanjie Li, Xiangbo Kong   +10 more
doaj   +1 more source

Pragmatic methods for reviewing exceptionally large bodies of evidence: systematic mapping review and overview of systematic reviews using lung cancer survival as an exemplar

Systematic Reviews, 2019
Introduction Lung cancer (LC) is the most common cause of cancer death in the world and associated with significant economic burden. We conducted a review of published literature to identify prognostic factors associated with LC survival and determine ...
Ruth Lewis, Maggie Hendry, Nafees Din, Marian A. Stanciu, Sadia Nafees, Annie Hendry, Zhi Hao Teoh, Thomas Lloyd, Rachel Parsonage, Richard D. Neal, Gareth Collier, Dyfed W. Huws   +11 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Mesenchymal stem cells for the treatment of articular cartilage defects of the knee: an overview of systematic reviews [PDF]

Anais da Academia Brasileira de Ciências
There is no consensus on the ideal type, dose, expansion, and differentiation of MSCs for treating knee cartilage defects. Our goal was to perform an overview of systematic reviews regarding the use of MSCs for the treatment of articular cartilage ...
EDUARDO B. DE SOUSA, RENATA AKEMI M. MATSUI, LEONARDO C. BOLDRINI, LEANDRA S. BAPTISTA, JOSÉ MAURO GRANJEIRO   +4 more
doaj   +1 more source

Acupuncture for insomnia? An overview of systematic reviews

European Journal of General Practice, 2011
Several systematic reviews of acupuncture as a treatment of insomnia have recently emerged. Their results are far from uniform.To summarize and critically evaluate these reviews with a view of defining the reasons for their discrepant conclusions and providing an overall verdict about the therapeutic value of acupuncture for insomnia.Thirteen ...
Edzard, Ernst, Myeong Soo, Lee, Tae-Young, Choi   +2 more
openaire   +2 more sources