Results 81 to 90 of about 1,628,215 (304)

Constructing the foundations of capacity building: an activity theory analysis of the English in Action baseline studies [PDF]

, 2009
This paper offers insights from an activity theory perspective into the English in Action (EiA) project in an attempt to reveal the motivations accompanying the selection of particular areas of focus for the baseline studies.
Kirkwood, Adrian, Rae, Jan
core  

Self-healing composites: A review [PDF]

, 2015
Self-healing composites are composite materials capable of automatic recovery when damaged. They are inspired by biological systems such as the human skin which are naturally able to heal themselves.
Ji, Chunqian, Pham, Duc Truong, Wang, Yongjing   +2 more
core   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

The safety and effectiveness of music medicine as an intervention for depression: A systematic evaluation and re‐evaluation

Brain and Behavior
Background As the methodological quality and evidence level of the existing systematic reviews (SRs) on music as an intervention for depression have not been thoroughly evaluated, a systematic evaluation and re‐evaluation (SERE) was conducted.
Dayuan Zhong, Hui Cheng, Zhenghua Pan, Yumei Liu, Pingwen Liu, Jiarong Li, Jiaqi Chen, Yihui Deng, Xueming Ou, Huanjie Li, Xiangbo Kong   +10 more
doaj   +1 more source

A decision tool to help researchers make decisions about including systematic reviews in overviews of reviews of healthcare interventions

Systematic Reviews, 2019
Background Overviews of reviews of healthcare interventions (overviews) integrate information from multiple systematic reviews (SRs) to provide a single synthesis of relevant evidence for decision-making.
Michelle Pollock, Ricardo M. Fernandes, Amanda S. Newton, Shannon D. Scott, Lisa Hartling   +4 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

High-Energy Aspects of Solar Flares: Overview of the Volume

, 2011
In this introductory chapter, we provide a brief summary of the successes and remaining challenges in understanding the solar flare phenomenon and its attendant implications for particle acceleration mechanisms in astrophysical plasmas. We also provide a
A. G. Emslie, A.G. Emslie, A.G. Emslie, A.G. Emslie, A.G. Emslie, A.G. Emslie, A.G. Emslie, A.G. Emslie, A.Y. Shih, B. R. Dennis, B.R. Dennis, D.J. Forrest, D.J. Forrest, D.M. Rust, D.M. Smith, D.M. Smith, D.S. Spicer, E. Kontar, E. Tandberg-Hanssen, E.L. Chupp, G. Haerendel, G. Haerendel, G. Holman, G.H. Share, G.H.J. van den Oord, G.J. Hurford, G.J. Hurford, G.J. Hurford, H. Carmichael, H. Hudson, H. S. Hudson, H.E. Petschek, H.S. Hudson, J. Heyvaerts, J. Sato, J.A. Miller, J.C. Brown, J.C. Brown, J.C. Brown, J.T. Gosling, J.W. Knight, L. Fletcher, L. Fletcher, N. Vilmer, P.A. Sturrock, P.A. Sturrock, P.A. Sweet, R. Lin, R. Ramaty, R. Ramaty, R.A. Kopp, R.F. van Oss, R.P. Lin, R.P. Lin, S. White, T. Gold, T. Hirayama, T. Sakao, T.N. Larosa, T.S. Bastian, V.V. Zharkova, V.V. Zharkova   +61 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source